The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Tretinoin-loaded nanocapsules: Preparation, physicochemical characterization, and photostability study
Abstract
The aim of this study was to prepare and characterize tretinoin-loaded nanocapsules as well as to evaluate the influence of this nanoencapsulation on tretinoin photostability. Tretinoin-loaded nanocapsules (0.5 mg ml(-1)) were prepared by interfacial deposition of preformed polymer (poly-epsilon-caprolactone) using two different oily phases: capric/caprylic triglycerides and sunflower seed oil. Tretinoin-loaded nanocapsules presented drug content close to the theoretical value, encapsulation efficiencies higher than 99.9%, nanometric mean size with a polydispersity index below 0.25, and pH values between 5.0 and 7.0. Regarding photodegradation studies, tretinoin methanolic solution showed a half-life time around 40 min according to a first order equation, whereas tretinoin nanocapsule suspensions showed a half-life between 85 and 100 min (twofold higher than in methanolic solution) according to a zero order equation. Tretinoin-loaded nanocapsules improved tretinoin photostability, independently on the type of oily phase used in this study, and represent a potential system to be incorporated in topical or systemic dosage forms containing tretinoin.
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From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [80]
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Self-citation
Metadata
- Authors
- Ourique, A. F., Pohlmann, A. R., Guterres, S. S., & Beck, R. C. R.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Beck, R.C.R.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 352
- Issue
- 1-2
- Pages
- 1-4
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2006560775
- Cited by
- 145
- References
- 29
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- all-trans retinoic acid, nanocapsules, polycaprolactone, interfacial deposition, photostability, photodegradation, encapsulation efficiency, triglycerides, sunflower oil, topical drug delivery
- MeSH terms
- Sunflower Oil, Caprylates, Chemistry, Pharmaceutical, Decanoic Acids, Dermatologic Agents, Drug Compounding, Drug Stability, Feasibility Studies, Half-Life, Kinetics, Particle Size, Photolysis, Plant Oils, Polyesters, Solubility, Technology, Pharmaceutical, Tretinoin, Triglycerides, Ultraviolet Rays, Nanocapsules
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