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Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products
Abstract
During the last 10-15 years, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with currently five products on the market. The major characteristic of these systems is the rapid dissolution velocity, enabling bioavailability enhancement after oral administration. This mini-review focuses on recent advances with respect to three topics considering drug nanocrystals. The first topic is nanosuspension stabilization. A current literature status is provided and special attention is given to studies attempting to extend our physicochemical understanding of the underlying principles. The second part describes recent advances on miniaturization of nanosuspension production, to enable formulation screening during preclinical development. Finally, literature available on further nanosuspensions solidification is discussed, focussing on the maintenance of the preservation of the rapid dissolution properties of the nanocrystals after further downstream processing.
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Cited by
The big picture on nanomedicine: the state of investigational and approved nanomedicine products
Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088
Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs
Lu, Y., & Park, K. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.042 · Cited by 572
Drug nanocrystals: in vivo performances.
Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.013 · Cited by 347
Overcoming poor oral bioavailability using nanoparticle formulations – opportunities and limitations
Desai, P. P., Date, A. A., & Patravale, V. B. (2012) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2011.12.001 · Cited by 199
Nanocrystals: a perspective on translational research and clinical studies
Jarvis, M., Krishnan, V., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10122 · Cited by 162
Metadata
- Authors
- Van Eerdenbrugh, B., Van den Mooter, G., & Augustijns, P.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 364
- Issue
- 1
- Pages
- 64-75
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2167642476
- Cited by
- 717
- References
- 0
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Van Eerdenbrugh, B., Van den Mooter, G., & Augustijns, P. (2008). Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2008.07.023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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