Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Drug-like properties and the causes of poor solubility and poor permeability

Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776 · see citing works

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Gradishar, W. J., Tjulandin, S., Davidson, N. G. P., Shaw, H., Desai, N. P., Bhar, P., Hawkins, M., & O’Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,159 · see citing works

Formation and stability of nano-emulsions

Tadros, T. F., Izquierdo, P., Esquena, J., & Solans, C. (2003) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2003.10.023 · Cited by 2,040 · see citing works

Block copolymer micelles: preparation, characterization and application in drug delivery

Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498 · see citing works

Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery

Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474 · see citing works

Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems

Pouton, C. W. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00167-6 · Cited by 1,232 · see citing works

Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications

Kawabata, Y., Wada, K., Nakatani, M., Yamada, S., & Onoue, S. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.032 · Cited by 1,194 · see citing works

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

Hrkach, J. S., Hoff, D. D. V., Ali, M. M., Andrianova, E. A., Auer, J., Campbell, T., Witt, D. D., Figa, M. A., Figueiredo, M., Horhota, A. T., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003651 · Cited by 1,147 · see citing works

Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation

KECK, C., & MULLER, R. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2005.05.009 · Cited by 1,061 · see citing works

Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies

Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821 · see citing works

Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract1PII of original article: S0169-409X(96)00487-5. The article was originally published in Advanced Drug Delivery Reviews 25 (1997) 3–14.1

Hörter, D., & Dressman, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00130-7 · Cited by 819 · see citing works

Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs

Liversidge, G. G., & Cundy, K. C. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)00122-y · Cited by 741 · see citing works

In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy

Kim, S. C., Kim, D. W., Shim, Y. H., Bang, J. S., Oh, H. S., Kim, S. W., & Seo, M. H. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00275-9 · Cited by 734 · see citing works

Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products

Eerdenbrugh, B. V., den Mooter, G. V., & Augustijns, P. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.023 · Cited by 719 · see citing works

Thermo-sensitive polymeric micelles based on poly (N-isopropylacrylamide) as drug carriers

Wei, H., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.05.002 · Cited by 718 · see citing works

Abraxane®, a novel Cremophor®-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer

Green, M. R., Manikhas, G. M., Орлов, С. В., Afanasyev, B. V., Makhson, A. M., Bhar, P., & Hawkins, M. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl104 · Cited by 671 · see citing works

Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs

Lukyanov, A. N., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.004 · Cited by 654 · see citing works

Nanonization strategies for poorly water-soluble drugs

Chen, H., Khemtong, C., Yang, X., Chang, X., & Gao, J. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.02.009 · Cited by 642 · see citing works

Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

Matsumura, Y., Hamaguchi, T., Ura, T., Muro, K., Yamada, Y., Shimada, Y., Shirao, K., Okusaka, T., Ueno, H., Ikeda, M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602204 · Cited by 623 · see citing works

Doxorubicin-loaded poly(ethylene glycol)–poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance

Kataoka, K., Matsumoto, T., Yokoyama, M., Okano, T., Sakurai, Y., Fukushima, S., Okamoto, K., & Kwon, G. S. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00133-9 · Cited by 613 · see citing works

Complement activation-related pseudoallergy: A new class of drug-induced acute immune toxicity

Szebeni, J. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.023 · Cited by 610 · see citing works

Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.

Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y., Nishio, K., Matsumura, Y., & Kataoka, K. (2003) · PubMed · Cited by 602 · see citing works

Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging

SCHILLER, C., FRÖHLICH, C. ‐., Gießmann, T., Siegmund, W., Mönnikes, H., Hosten, N., & Weitschies, W. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02683.x · Cited by 599 · see citing works

Nanoemulsions: a new vehicle for skincare products

Sonneville-Aubrun, O., Simonnet, J., & L'Alloret, F. (2004) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2003.10.026 · Cited by 591 · see citing works

Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds

Merisko-Liversidge, E. M., & Liversidge, G. G. (2008) · Toxicologic Pathology · doi:10.1177/0192623307310946 · Cited by 581 · see citing works

Development of the polymer micelle carrier system for doxorubicin

Nakanishi, T., Fukushima, S., Okamoto, K., Suzuki, M., Matsumura, Y., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00341-8 · Cited by 570 · see citing works

Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer

Lee, K. S., Chung, H. C., Im, S. A., Park, Y. H., Kim, C. S., Kim, S.-B., Rha, S. Y., Lee, M. Y., & Ro, J. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9591-y · Cited by 541 · see citing works

Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs

Jinno, J.-I., Kamada, N., Miyake, M., Yamada, K., Mukai, T., Odomi, M., Toguchi, H., Liversidge, G. G., Higaki, K., & Kimura, T. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.013 · Cited by 509 · see citing works

Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502 · cited 1× · see citing works

Nanosuspensions for the Formulation of Poorly Soluble Drugs

Müller, R. H., Jacobs, C., & Kayser, O. (2000) · Drugs and the pharmaceutical sciences · doi:10.1201/b14005-13 · Cited by 502 · see citing works

Nanosuspensions for the formulation of poorly soluble drugs

Müller, R. H., & Peters, K. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00311-6 · Cited by 481 · see citing works

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R., & Muggia, F. M. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg374 · Cited by 479 · see citing works

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

Uchino, H., Matsumura, Y., Negishi, T., Koizumi, F., Hayashi, T., Honda, T., Nishiyama, N., Kataoka, K., Naito, S., & Kakizoe, T. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602772 · Cited by 430 · see citing works

Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract

Hörter, D., & Dressman, J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00487-5 · Cited by 393 · see citing works

pH‐Triggered Thermally Responsive Polymer Core–Shell Nanoparticles for Drug Delivery

Soppimath, K. S., Tan, D., & Yang, Y. ‐. (2005) · Advanced Materials · doi:10.1002/adma.200401057 · Cited by 390 · see citing works

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours

Plummer, R., Wilson, R. H., Calvert, H., Boddy, A. V., Griffin, M., Sludden, J., Tilby, M. J., Eatock, M., Pearson, D. G., Ottley, C. J., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.6 · Cited by 390 · see citing works

Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382 · see citing works

New Amphipatic Polymer-Lipid Conjugates Forming Long-Circulating Reticuloendothelial System-Evading Liposomes

Woodle, M. C., Engbers, C. M., & Zalipsky, S. (1994) · Bioconjugate Chemistry · doi:10.1021/bc00030a001 · Cited by 361 · see citing works

Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer

Kim, D.-W., Kim, S.-Y., Kim, H.-K., Kim, S.-W., Shin, S. W., Kim, J. S., Park, K., Lee, M. Y., & Heo, D. S. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm374 · Cited by 356 · see citing works

Preparation and characterization of poly(lactic acid)–poly(ethylene glycol)–poly(lactic acid) (PLA–PEG–PLA) microspheres for controlled release of paclitaxel

Ruan, G., & Feng, S. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00419-8 · Cited by 348 · see citing works

Accelerated clearance of PEGylated liposomes in rats after repeated injections

Ishida, T., Maeda, R., Ichihara, M., Irimura, K., & Kiwada, H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00462-5 · Cited by 327 · see citing works

Fast Release of Lipophilic Agents from Circulating PEG-PDLLA Micelles Revealed by<i>in Vivo</i>Förster Resonance Energy Transfer Imaging

Chen, H., Kim, S., He, W., Wang, H., Low, P. S., Park, K., & Cheng, J.-X. (2008) · Langmuir · doi:10.1021/la703570m · Cited by 311 · see citing works

Microemulsion formulation for enhanced absorption of poorly soluble drugs

Kawakami, K., Yoshikawa, T., Moroto, Y., Kanaoka, E., Takahashi, K. S., Nishihara, Y., & Masuda, K. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00049-4 · Cited by 306 · see citing works

A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

Valle, J. W., Armstrong, A., Newman, C., Alakhov, V., Pietrzynski, G., Brewer, J., Campbell, S., Corrie, P., Rowinsky, E. K., & Ranson, M. (2011) · Investigational New Drugs · doi:10.1007/s10637-010-9399-1 · Cited by 303 · see citing works

A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation

Hamaguchi, T., Kato, K., Yasui, H., Morizane, C., Ikeda, M., Ueno, H., Muro, K., Yamada, Y., Okusaka, T., Shirao, K., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603855 · Cited by 290 · see citing works

Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules

Peltier, S., Oger, J.-M., Lagarce, F., et al. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0022-2 · Cited by 274 · see citing works

Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide)

Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., & Okano, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00023-6 · Cited by 273 · see citing works

Multicenter Phase II Trial of ABI-007, an Albumin-Bound Paclitaxel, in Women With Metastatic Breast Cancer

Ibrahim, N. K., Samuels, B. L., Page, R. D., Doval, D. C., Patel, K. M., Rao, S., Nair, M. K., Bhar, P., Desai, N. P., & Hortobágyi, G. N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.11.013 · Cited by 267 · see citing works

Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials

Alakhov, V. Y., Klinski, E., Li, S., Pietrzyński, G., Venne, A., Batrakova, E. V., Bronich, T. K., & Kabanov, A. V. (1999) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00064-8 · Cited by 266 · see citing works

Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe

Bali, V., Ali, M., & Ali, J. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.11.021 · Cited by 263 · see citing works

The effect of physical barriers and properties on the oral absorption of particulates

Norris, D. A. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00037-4 · Cited by 262 · see citing works

Preparation of nanoparticles by continuous-flow microfluidics

Jahn, Α., Reiner, J. E., Vreeland, W. N., DeVoe, D. L., Locascio, L. E., & Gaitan, M. (2008) · Journal of Nanoparticle Research · doi:10.1007/s11051-007-9340-5 · Cited by 260 · see citing works

Novel SN-38–Incorporating Polymeric Micelles, NK012, Eradicate Vascular Endothelial Growth Factor–Secreting Bulky Tumors

Koizumi, F., Kitagawa, M., Negishi, T., Onda, T., Matsumoto, S.-I., Hamaguchi, T., & Matsumura, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1605 · Cited by 257 · see citing works

Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles

Park, K., Kim, J., Nam, Y. S., Lee, S., Nam, H. Y., Kim, K., Park, J. H., Kim, I., Choi, K., Kim, S. Y., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.009 · Cited by 257 · see citing works

Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel

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In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: Effects of PEG chain length and PC incorporation

Ashok, B., Arleth, L., Hjelm, R. P., Rubinstein, I., & Önyüksel, H. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20150 · Cited by 255 · see citing works

Solid Dispersion as an Approach for Bioavailability Enhancement of Poorly Water-Soluble Drug Ritonavir

Sinha, S., Ali, M., Baboota, S., Ahuja, A., Kumar, A., & Ali, J. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9404-1 · Cited by 235 · see citing works

Unusual selectivity in solubilization by block copolymer micelles

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Advances in lipid nanodispersions for parenteral drug delivery and targeting

Constantinides, P. P., Chaubal, M. V., & Shorr, R. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.013 · Cited by 230 · see citing works

Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion

Batrakova, E. V., Li, S., Elmquist, W. F., Miller, D. W., Alakhov, V. Y., & Kabanov, A. V. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2165 · Cited by 229 · see citing works

Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique

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Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel

Hu, F., Guo-fei, R., Yuan, H., Du, Y., & Zeng, S. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.04.009 · Cited by 220 · see citing works

Camptothecins: a review of their development and schedules of administration

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Micelles based on HPMA copolymers☆

Talelli, M., Rijcken, C. J. F., van Nostrum, C. F., Storm, G., & Hennink, W. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.029 · Cited by 208 · see citing works

Hydrotropic Polymeric Micelles for Enhanced Paclitaxel Solubility: In Vitro and In Vivo Characterization

Lee, S. C., Huh, K. M., Lee, J., Cho, Y. W., Galinsky, R. E., & Park, K. (2006) · Biomacromolecules · doi:10.1021/bm060307b · Cited by 206 · see citing works

Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: Some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux

Dabholkar, R. D., Sawant, R., Mongayt, D. A., Devarajan, P. V., & Torchilin, V. P. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.02.018 · Cited by 201 · see citing works

Polymeric micelles for oral drug delivery: Why and how

Francis, M. F., Cristea, M., & Winnik, F. M. (2004) · Pure and Applied Chemistry · doi:10.1351/pac200476071321 · Cited by 197 · see citing works

Accelerated clearance of a second injection of PEGylated liposomes in mice

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Enhanced solubility of paclitaxel using water‐soluble and biocompatible 2‐methacryloyloxyethyl phosphorylcholine polymers

Konno, T., Watanabe, J., & Ishihara, K. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10481 · Cited by 180 · see citing works

From Cyclodextrin Assemblies to Porous Materials by Silica Templating We thank the Max-Planck society for funding.

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Hybridization of block copolymer micelles

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Effects of Pluronic Block Copolymers on Drug Absorption in Caco-2 Cell Monolayers

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Combined cancer therapy by micellar-encapsulated drug and ultrasound

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Transcellular uptake mechanisms of the intestinal epithelial barrier Part one

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Hydrotropic Solubilization of Poorly Water-Soluble Drugs

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Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors

Hamaguchi, T., Doi, T., Nakajima, T. E., Kato, K., Yamada, Y., Shimada, Y., Fuse, N., Ohtsu, A., Matsumoto, S.-I., Takanashi, M., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0387 · Cited by 144 · see citing works

Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent

Kang, J., Kumar, V., Yang, D. J., et al. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00214-7 · Cited by 140 · see citing works

Forecasting in vivo oral absorption and food effect of micronized and nanosized aprepitant formulations in humans

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Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies

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Applications of Microemulsion Based Drug Delivery System

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The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers*

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Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats

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Solubilization and stabilization of camptothecin in micellar solutions of pluronic-g-poly(acrylic acid) copolymers

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Novel Biodegradable Polylactide/poly(ethylene glycol) Micelles Prepared by Direct Dissolution Method for Controlled Delivery of Anticancer Drugs

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Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose

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An investigation of the antitumour activity and biodistribution of polymeric micellar paclitaxel

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