The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review
Open accessAbstract
The ICH quality vision introduced the concept of quality by design (QbD), which requires a greater understanding of the raw material attributes, of process parameters, of their variability and their interactions. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Therefore excipients' variability and their impact on drug product performance need to be thoroughly understood. To help with this process, this review article gathers prior knowledge on MCC, focuses on its use in DC and lists some of its potential critical material attributes (CMAs).
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Cites
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Developing fibrillated cellulose as a sustainable technological material
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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
Janmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.018 · Cited by 323
Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review
Salimi, S., Sotudeh-Gharebagh, R., Zarghami, R., Chan, S. Y., & Yuen, K. H. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b02744 · Cited by 268
Algae as a Source of Microcrystalline Cellulose
Samiee, S., Ahmadzadeh, H., Hosseini, M., & Lyon, S. (2019) · Advanced Bioprocessing for Alternative Fuels, Biobased Chemicals, and Bioproducts · doi:10.1016/b978-0-12-817941-3.00017-6 · Cited by 29
Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections
Khanal, D., Chang, R. Y. K., Hick, C., Morales, S., & Chan, H.-K. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121206 · Cited by 28
Metadata
- Authors
- Thoorens, G., Krier, F., Leclercq, B., Carlin, B., & Evrard, B.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 473
- Issue
- 1-2
- Pages
- 64-72
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2009242118
- Cited by
- 549
- References
- 30
- FWCI
- 28.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Thoorens, G., Krier, F., Leclercq, B., Carlin, B., & Evrard, B. (2014). Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2014.06.055
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
