Cited by 68Nanoparticle-Based Drug DeliveryCurcumin's Biomedical ApplicationsAdvanced Drug Delivery Systems

Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios

Phan, Quoc Thong, Le, Mai Huong, Le, Thi Thu Huong, Tran, Thi Hong Ha, Xuan, Phuc Nguyen, Ha, Phuong Thu·2016·International Journal of Pharmaceutics

Abstract

Targeting delivery system use natural drugs for tumor cells is an appealing platform help to reduce the side effects and enhance the therapeutic effects of the drug. In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy. The PLA-PEG copolymer was synthesized by ring opening polymerization method. After loading onto the micelle, solubility of Cur increased from 0.38 to 0.73mgml(-1). The average size of prepared Cur/PLA-PEG micelles was from 60 to 69nm (corresponding to the ratio difference of PLA/PEG) and the drug encapsulating efficiency was from 48.8 to 91.3%. Compared with the Cur/PLA-PEG micelles, the size of Cur/PLA-PEG-Fol micelles were from 80 to 86nm and showed better in vitro cellular uptake and cytotoxicity towards HepG2 cells. The cytotoxicity of the NPs however depends much on the PEG component. The results demonstrated that Folate-modified micelles could serve as a potential nano carrier to improve solubility, anti-cancer activity of Cur and targeting ability of the system.

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Crossref · 10.1016/j.ijpharm.2016.05.003

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Authors
Phan, Q. T., Le, M. H., Le, T. T. H., Tran, T. H. H., Xuan, P. N., & Ha, P. T.
Affiliations
  • University of Khanh Hoa (VN)
  • Vietnam Academy of Science and Technology (VN)
  • Institute of Materials Science (VN)
Corresponding author
Ha, Phuong Thu
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2016-06
Volume
507
Issue
1-2
Pages
32-40
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2345823350
Cited by
68
References
35
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 11 · 2017: 8
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Foundation for Science and Technology Development
  • Viện Khoa học vật liệu, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
curcumin, polymeric micelles, targeted drug delivery, cytotoxicity, HepG2 cells, drug solubility enhancement, encapsulation efficiency, nanoparticle size, cellular uptake, anticancer nanocarriers
MeSH terms
Cell Survival, Cells, Cultured, Curcumin, Drug Carriers, Folic Acid, Humans, Micelles, Particle Size, Polyethylene Glycols, Solubility, Nanoparticles, Drug Liberation

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