Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios
Abstract
Targeting delivery system use natural drugs for tumor cells is an appealing platform help to reduce the side effects and enhance the therapeutic effects of the drug. In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy. The PLA-PEG copolymer was synthesized by ring opening polymerization method. After loading onto the micelle, solubility of Cur increased from 0.38 to 0.73mgml(-1). The average size of prepared Cur/PLA-PEG micelles was from 60 to 69nm (corresponding to the ratio difference of PLA/PEG) and the drug encapsulating efficiency was from 48.8 to 91.3%. Compared with the Cur/PLA-PEG micelles, the size of Cur/PLA-PEG-Fol micelles were from 80 to 86nm and showed better in vitro cellular uptake and cytotoxicity towards HepG2 cells. The cytotoxicity of the NPs however depends much on the PEG component. The results demonstrated that Folate-modified micelles could serve as a potential nano carrier to improve solubility, anti-cancer activity of Cur and targeting ability of the system.
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PEG-PLA micelles have excellent biodegradability and low toxicity.
“Besides, the characteristics of excellent biodegradability and low toxicity will facilitate their wide applications in drug or gene delivery.42”
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- Authors
- Phan, Q. T., Le, M. H., Le, T. T. H., Tran, T. H. H., Xuan, P. N., & Ha, P. T.
- Affiliations
- University of Khanh Hoa (VN)
- Vietnam Academy of Science and Technology (VN)
- Institute of Materials Science (VN)
- Corresponding author
- Ha, Phuong Thu
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 507
- Issue
- 1-2
- Pages
- 32-40
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2345823350
- Cited by
- 68
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 11 · 2017: 8
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Foundation for Science and Technology Development
- Viện Khoa học vật liệu, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- curcumin, polymeric micelles, targeted drug delivery, cytotoxicity, HepG2 cells, drug solubility enhancement, encapsulation efficiency, nanoparticle size, cellular uptake, anticancer nanocarriers
- MeSH terms
- Cell Survival, Cells, Cultured, Curcumin, Drug Carriers, Folic Acid, Humans, Micelles, Particle Size, Polyethylene Glycols, Solubility, Nanoparticles, Drug Liberation
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