The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Safety assessment of polymeric micelles as an ophthalmic drug delivery system for intravitreal administration of dasatinib
Abstract
Background and aims Ocular safety/biocompatibility is an essential element of ophthalmic drug delivery. We previously applied poly(ethylene glycol)-block-poly(ɛ-caprolactone) (PEG-b-PCL) micelles to deliver dasatinib for the management of proliferative vitreoretinopathy (PVR) in vitro. Herein, we seek to ascertain the ocular safety/compatibility of blank and dasatinib loaded PEG-b-PCL micelles, which will set the stage for the future in vivo efficacy evaluations and/or clinical translation for PVR or other eye diseases.Methods To access the safety of blank and dasatinib loaded micelles, in vitro cell based assays (LDH cell membrane damage test, SRB cytotoxicity, TEER and permeability of RPE tight junctions), in vivo slit lamp biomicroscopy and optical coherence tomography, Ex vivo histology (H&E staining, GFAP immunofluorescence staining and TUNEL assay) were undertaken.Results Both blank and dasatinib loaded micelles showed remarkable safety profiles at cellular levels. They also caused negligible ocular toxicity/abnormalities up to 28 days post-intravitreal injection in mice. The micelles did not insult the cornea, as demonstrated by slit-lamp biomicroscopy. Ex vivo histology and in vivo optical coherence tomography revealed a normal retinal structure with minimal apoptosis and stresses.Conclusion Taken together, both blank and dasatinib loaded micelles appear to be safe and their applications in drug delivery for eye diseases should be explored.
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In the citing paper
“This result indicates that PEG-b-PCL nanomicelles can not only maintain good biocompatibility in vivo, but also be effectively delivered to the deep ocular tissues and act on the retina through specific administration routes (such as vitreous injection), indirectly demonstrating its ability to break through the limitations of the blood-eye barrier on drug delivery.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [49]
In the citing paper
“Recently, a study on polyethylene glycol-polycaprolactone block copolymer (PEG-b-PCL) nanomicelles showed that neither blank micelles nor PEG-b-PCL micelles with adaxatinib were found to have obvious ocular toxicity or structural abnormalities during the 28-day in vivo observation period after intravitreal injection in mice.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [49]
In the citing paper
“Li et al. successfully encapsulated dasatinib within nanoparticles derived from PEG-b-PCL micelles to enhance its solubility by 475-fold while ensuring sustained drug release.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [49]
In the citing paper
“Results indicated that both blank micelles and those containing dasatinib exhibited excellent safety profiles at cellular levels [49,189].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [49]
In the citing paper
“Micellar formulations of dasatinib significantly restrained cell proliferation, adhesion, and migration compared to free dasatinib.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [49]
Citations
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Proliferative Vitreoretinopathy
Jimeno, J. C. P. (1998) · Survey of Ophthalmology · doi:10.1016/s0039-6257(98)00023-x · Cited by 411
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- Groot, R.D., Rabone, K.L. Mesoscopic simulation of cell membrane damage, morphology change and rupture by nonionic surfactants. (0006-3495 (Print)). doi:D - NLM: PMC1301549 EDAT- 2001/07/21 10:00 MHDA- 2001/10/19 10:01 CRDT- 2001/07/21 10:00 AID - S0006-3495(01)75737-2 [pii] AID - 10.1016/S0006-3495(01)75737-2 [doi] PST – ppublish. · DOI
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Han, H., Li, S., Xu, M., Zhong, Y., Fan, W., Xu, J., Zhou, T., Ji, J., Ye, J., & Yao, K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114770 · Cited by 341
Nano-based eye drop: Topical and noninvasive therapy for ocular diseases
Wang, C., & Pang, Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114721 · Cited by 109
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment
Jiang, H., & Xu, Z. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2204206 · Cited by 64
Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics
Datta, D., Bandi, S. P., Colaco, V., Dhas, N. L., Reddy, D. S., & Vora, L. K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124192 · Cited by 41
Khursheed, R., Paudel, K. R., Gulati, M., Vishwas, S., Jha, N. K., Hansbro, P. M., Oliver, B. G. G., Dua, K., & Singh, S. K. (2022) · Nanomedicine · doi:10.2217/nnm-2021-0451 · Cited by 29
Metadata
- Authors
- Li, Q., Qian, X., Li, H. Y., Lai, K. L., Gao, Q., & Lee, W. Y. T.
- Affiliations
- Chinese University of Hong Kong (HK)
- Sun Yat-sen University (CN)
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 596
- Pages
- 120226
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W3125779010
- Cited by
- 26
- References
- 38
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 6
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese University of Hong Kong
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- polymeric micelles, PEG-b-PCL, dasatinib, intravitreal drug delivery, eye safety, biocompatibility, proliferative vitreoretinopathy, retinal pigment epithelium, tight junction permeability, ocular toxicity, apoptosis, eye diseases
- MeSH terms
- Dasatinib, Animals, Cell Survival, Drug Carriers, Micelles, Polyesters, Polyethylene Glycols, Polymers, Drug Delivery Systems, Mice
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