Amphiphilic block copolymers for drug delivery

Adams, Monica L.; Lavasanifar, Afsaneh; Kwon, Glen S.

doi:10.1002/jps.10397

Cited by 1,078Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationAdvanced Drug Delivery Systems

Amphiphilic block copolymers for drug delivery

Adams, Monica L., Lavasanifar, Afsaneh, Kwon, Glen S.·2003·Journal of Pharmaceutical Sciences

DOI 10.1002/jps.10397

Open this paper in CoChat — free account

Abstract

Amphiphilic block copolymers (ABCs) have been used extensively in pharmaceutical applications ranging from sustained-release technologies to gene delivery. The utility of ABCs for delivery of therapeutic agents results from their unique chemical composition, which is characterized by a hydrophilic block that is chemically tethered to a hydrophobic block. In aqueous solution, polymeric micelles are formed via the association of ABCs into nanoscopic core/shell structures at or above the critical micelle concentration. Upon micellization, the hydrophobic core regions serve as reservoirs for hydrophobic drugs, which may be loaded by chemical, physical, or electrostatic means, depending on the specific functionalities of the core-forming block and the solubilizate. Although the Pluronics, composed of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), are the most widely studied ABC system, copolymers containing poly(L-amino acid) and poly(ester) hydrophobic blocks have also shown great promise in delivery applications. Because each ABC has unique advantages with respect to drug delivery, it may be possible to choose appropriate block copolymers for specific purposes, such as prolonging circulation time, introduction of targeting moieties, and modification of the drug-release profile. ABCs have been used for numerous pharmaceutical applications including drug solubilization/stabilization, alteration of the pharmacokinetic profile of encapsulated substances…

Integrity signals

Registry

Crossref · 10.1002/jps.10397

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Micelles with lower CMC are preferable in drug delivery systems because of their relatively higher stability and insensitivity to dilution, which enables longer circulation in the bloodstream.
“Micelles with lower CMC are preferable in DDSs because of their relatively higher stability and insensitivity to the dilution, which enables their longer circulations in the bloodstream [36].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [36]
Low molecular weight surfactants have considerably higher CMC, 10−3 to 10−4 M, compared to polymeric amphiphilic molecules, which have a CMC in the range of 10−6 to 10−7 M.
“have considerably higher CMC, which is 10−3 to 10−4 M, compared to polymeric amphiphilic molecules, which has a CMC located in the range of 10−6 to 10−7 M.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [36]

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438 · see citing works
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706 · see citing works
Protein—surface interactions in the presence of polyethylene oxide
Jeon, S. I., Lee, J. H., Andrade, J. D., & De Gennes, P. G. (1991) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(91)90043-8 · Cited by 1,523 · see citing works
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474 · see citing works
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256 · see citing works
Advanced drug delivery devices via self-assembly of amphiphilic block copolymers
Rösler, A., Vandermeulen, G. W. M., & Klok, H. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00222-8 · Cited by 1,169 · see citing works
Multidrug resistance (MDR) in cancer
Krishna, R., & Mayer, L. D. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00114-7 · Cited by 1,032 · see citing works
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
Maeda, H., Sawa, T., & Konno, T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00309-1 · Cited by 926 · see citing works
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994) · PubMed · Cited by 908 · see citing works
Block copolymer micelles as vehicles for drug delivery
Kataoka, K., Kwon Glenn, S., Masayuki, Y., Teruo, O., & Sakurai, Y. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90172-2 · Cited by 878 · see citing works
Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery
Lavasanifar, A., Samuel, J., & Kwon, G. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00015-7 · Cited by 756 · see citing works
Self-citation
Blood compatibility of polyethylene oxide surfaces
LEE, J., Lee, H. G., & ANDRADE, J. (1995) · Progress in Polymer Science · doi:10.1016/0079-6700(95)00011-4 · Cited by 703 · see citing works
Surfaces, interfaces, and colloids: principles and applications
(1999) · Choice Reviews Online · doi:10.5860/choice.37-1568 · Cited by 657 · see citing works
Doxorubicin-loaded poly(ethylene glycol)–poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance
Kataoka, K., Matsumoto, T., Yokoyama, M., Okano, T., Sakurai, Y., Fukushima, S., Okamoto, K., & Kwon, G. S. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00133-9 · Cited by 613 · see citing works
Self-citation
Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers
Harada, A., & Kataoka, K. (1999) · Science · doi:10.1126/science.283.5398.65 · Cited by 598 · see citing works
Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA–PEG block copolymer
Yoo, H. S., & Park, T. G. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00340-0 · Cited by 539 · see citing works
In situ forming degradable networks and their application in tissue engineering and drug delivery
Anseth, K. S., Metters, A. T., Bryant, S. J., Martens, P. J., Elisseeff, J. H., & Bowman, C. N. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00500-4 · Cited by 479 · see citing works
The uses and properties of PEG-linked proteins.
Delgado, C., Francis, G. E., & Fisher, D. R. (1992) · PubMed · Cited by 423 · see citing works
Untitled work
(1991) · PubMed · Cited by 418 · see citing works
Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates
Kwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90118-x · Cited by 409 · see citing works
Self-citation
Development of amphiphilic diblock copolymers as micellar carriers of taxol
Zhang, X., Jackson, J. K., & Burt, H. M. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04386-1 · Cited by 402 · see citing works
Micelles based on AB block copolymers of poly (ethylene oxide) and poly (beta.-benzyl L-aspartate)
Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1993) · Langmuir · doi:10.1021/la00028a012 · Cited by 399 · see citing works
Self-citation
Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-lncorporated Polyfethylene oxide)-Poly(β-benzyl L-aspartate) Block Copolymer Micelles
La, S. B., Okano, T., & Kataoka, K. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950204r · Cited by 380 · see citing works
Pluronic® block copolymers: novel functional molecules for gene therapy
Kabanov, A. V., Lemieux, P., Vinogradov, S. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00018-2 · Cited by 376 · see citing works
Polycaprolactone–b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone
Allen, C. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00200-x · Cited by 352 · see citing works
ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins
Kissel, T., Li, Y., & Unger, F. T. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00244-7 · Cited by 332 · see citing works
Methoxy poly(ethylene glycol) and ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin.
Kim, S. Y., Shin, I. G., Lee, Y. M., Cho, C. S., & Sung, Y. K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00124-7 · Cited by 330 · see citing works
Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes
Kozlov, M. Y., Melik-Nubarov, N. S., Batrakova, E. V., & Kabanov, A. V. (2000) · Macromolecules · doi:10.1021/ma991634x · Cited by 322 · see citing works
Polymeric micelles: their relaxation kinetics
Halperin, A., & Alexander, S. (1989) · Macromolecules · doi:10.1021/ma00195a069 · Cited by 318 · see citing works
Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation
Wu, X. S., & Wang, N. (2001) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856201744425 · Cited by 317 · see citing works
Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor
Yokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308 · see citing works
Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer
Alakhov, V. Y., Moskaleva, E. Y., Batrakova, E. V., & Kabanov, A. V. (1996) · Bioconjugate Chemistry · doi:10.1021/bc950093n · Cited by 304 · see citing works
Mechanism of Pluronic Effect on P-Glycoprotein Efflux System in Blood-Brain Barrier: Contributions of Energy Depletion and Membrane Fluidization
Batrakova, E. V., Li, S., Vinogradov, S. V., Alakhov, V. Y., Miller, D. W., & Kabanov, A. V. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29254-5 · Cited by 292 · see citing works
Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells
Batrakova, E. V., Lee, S., Li, S., Venne, A., Alakhov, V. Y., & Kabanov, A. V. (1999) · Pharmaceutical Research · doi:10.1023/a:1018942823676 · Cited by 289 · see citing works
Polyether–polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations
Liggins, R. T., & Burt, H. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00016-9 · Cited by 286 · see citing works
Polycaprolactone-<i>b</i>-poly(ethylene Oxide) Block Copolymer Micelles as a Novel Drug Delivery Vehicle for Neurotrophic Agents FK506 and L-685,818
Allen, C., Yu, Y., Maysinger, D., & Eisenberg, A. (1998) · Bioconjugate Chemistry · doi:10.1021/bc9702157 · Cited by 273 · see citing works
Methoxy poly(ethylene glycol)/ϵ-caprolactone amphiphilic block copolymeric micelle containing indomethacin.
Shin, I. G., Kim, S. Y., Lee, Y. M., Cho, C. S., & Sung, Y. K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00164-8 · Cited by 269 · see citing works
Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
Burt, H. M., Zhang, X., Toleikis, P. M., Embree, L., & Hunter, W. L. (1999) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00067-3 · Cited by 255 · see citing works
Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies
Wei, G., Xu, H., Ding, P., Li, S. M., & Zheng, J. M. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00175-x · Cited by 248 · see citing works
Structure–activity relationships of poly(l-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery
Männistö, M., Vanderkerken, S., Toncheva, V., Elomaa, M. A., Ruponen, M., Schacht, E. H., & Urtti, A. O. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00178-5 · Cited by 232 · see citing works
Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion
Batrakova, E. V., Li, S., Elmquist, W. F., Miller, D. W., Alakhov, V. Y., & Kabanov, A. V. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2165 · Cited by 229 · see citing works
Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells.
Venne, A., Li, S., Mandeville, R., Kabanov, A. V., & Alakhov, V. Y. (1996) · PubMed · Cited by 225 · see citing works
Clonazepam release from core-shell type nanoparticles in vitro
Jeong, Y.-I., Cheon, J., Kim, S.-H., Nah, J., Lee, Y.-M., Sung, Y. K., Akaike, T., & Cho, C.-S. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00163-6 · Cited by 221 · see citing works
Introduction to Chemistry and Biological Applications of Poly(ethylene glycol)
Zalipsky, S., & Harris, J. M. (1997) · ACS symposium series · doi:10.1021/bk-1997-0680.ch001 · Cited by 220 · see citing works
Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers
Jeong, B., Bae, Y. H., & Kim, S. W. (1999) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00069-7 · Cited by 218 · see citing works
Amphiphilic poly-N-vinylpyrrolidones:
Torchilin, V. P., Levchenko, T. S., Whiteman, K. R., Yaroslavov, A. A., Tsatsakis, A. M., Rizos, A. K., Michailova, E. V., & Shtilman, M. I. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00050-3 · Cited by 214 · see citing works
Drug delivery in pluronic micelles: Effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Marin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00262-6 · Cited by 213 · see citing works
Pluronic P85 Increases Permeability of a Broad Spectrum of Drugs in Polarized BBMEC and Caco-2 Cell Monolayers
Batrakova, E. V., Li, S., Miller, D. W., & Kabanov, A. V. (1999) · Pharmaceutical Research · doi:10.1023/a:1018990706838 · Cited by 206 · see citing works
Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size
Yokoyama, M., Satoh, A., Sakurai, Y., Okano, T., Matsumura, Y., Kakizoe, T., & Kataoka, K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00054-6 · Cited by 203 · see citing works
Preparation, characterization, and drug release behaviors of drug nimodipine‐loaded poly(ε‐caprolactone)‐poly(ethylene oxide)‐poly(ε‐caprolactone) amphiphilic triblock copolymer micelles
Ge, H., Hu, Y., Jiang, X., Cheng, D., Yuan, Y., Bi, H., & Yang, C. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10143 · Cited by 199 · see citing works
Pluronic P85 Enhances the Delivery of Digoxin to the Brain: In Vitro and in Vivo Studies
Batrakova, E. V., Miller, D. W., Li, S., Alakhov, V. Y., Kabanov, A. V., & Elmquist, W. F. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38781-6 · Cited by 182 · see citing works
Sugar-Installed Polymer Micelles: Synthesis and Micellization of Poly(ethylene glycol)−Poly( d , l -lactide) Block Copolymers Having Sugar Groups at the PEG Chain End
Yasugi, K., NAKAMURA, T., Nagasaki, Y., Kato, M., & Kataoka, K. (1999) · Macromolecules · doi:10.1021/ma991066l · Cited by 176 · see citing works
Sugar-Installed Block Copolymer Micelles: Their Preparation and Specific Interaction with Lectin Molecules
Nagasaki, Y., Yasugi, K., Yamamoto, Y., Harada, A., & Kataoka, K. (2001) · Biomacromolecules · doi:10.1021/bm015574q · Cited by 171 · see citing works
Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin
Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90237-2 · Cited by 154 · see citing works
Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core
Nishiyama, N., & Kataoka, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00314-5 · Cited by 153 · see citing works
%Thermogelling Biodegradable Copolymer Aqueous Solutions for Injectable Protein Delivery and Tissue Engineering
Jeong, B., Lee, K. M., Gutowska, A., & An, Y. H. (2002) · Biomacromolecules · doi:10.1021/bm025536m · Cited by 152 · see citing works
Use of polyoxyethylene-lipid conjugates as long-circulating carriers for delivery of therapeutic and diagnostic agents
Trubetskoy, V. S., & Torchilin, V. P. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00032-3 · Cited by 148 · see citing works
Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block–poly(N-hexyl-l-aspartamide)-acyl conjugate micelles: effects of acyl chain length
Adams, M. L., & Kwon, G. S. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00347-4 · Cited by 147 · see citing works
Self-citation
Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate l-aspartamide) by a solvent evaporation method: effect on the solubilization and haemolytic activity of amphotericin B
Lavasanifar, A., Samuel, J., & Kwon, G. S. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00477-1 · Cited by 142 · see citing works
Self-citation
Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)–poly(d,l-lactide) block copolymer micelles in aqueous milieu
Yamamoto, Y., Yasugi, K., Harada, A., Nagasaki, Y., & Kataoka, K. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00147-5 · Cited by 140 · see citing works
Safety of Poly(ethylene glycol) and Poly(ethylene glycol) Derivatives
Working, P. K., Newman, M. S., Johnson, J. A., & Cornacoff, J. B. (1997) · ACS symposium series · doi:10.1021/bk-1997-0680.ch004 · Cited by 139 · see citing works
Block copolymer micelles as vehicles for hydrophobic drugs
Kwon, G. S., Naito, M., Kataoka, K., Yokoyama, M., Sakurai, Y., & Okano, T. (1994) · Colloids and Surfaces B Biointerfaces · doi:10.1016/0927-7765(94)80007-3 · Cited by 132 · see citing works
Self-citation
Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake
Rapoport, N. Y., Herron, J. N., Pitt, W. G., & Pitina, L. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00149-7 · Cited by 123 · see citing works
Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)–poly(l-Lysine) block copolymers
Harada, A., Togawa, H., & Kataoka, K. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00205-0 · Cited by 121 · see citing works
Methotrexate Esters of Poly(Ethylene Oxide)-Block-Poly(2-Hydroxyethyl-L-Aspartamide). Part I: Effects of the Level of Methotrexate Conjugation on the Stability of Micelles and on Drug Release
Li, Y., & Kwon, G. S. (2000) · Pharmaceutical Research · doi:10.1023/a:1007529218802 · Cited by 118 · see citing works
Self-citation
Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers
Harada, A., & Kataoka, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00264-4 · Cited by 115 · see citing works
Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound
Marin, A., Muniruzzaman, M., & Rapoport, N. Y. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00216-4 · Cited by 112 · see citing works
Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography
Yokoyama, M., Sugiyama, T., Okano, T., Sakurai, Y., Naito, M., & Kataoka, K. (1993) · Pharmaceutical Research · doi:10.1023/a:1018921513605 · Cited by 100 · see citing works
The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-?-aspartamide)
Lavasanifar, A. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00537-5 · Cited by 97 · see citing works
Self-citation
Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers
Liu, L., Li, C., Li, X., Yuan, Z., An, Y., & He, B. (2001) · Journal of Applied Polymer Science · doi:10.1002/app.1295 · Cited by 92 · see citing works
Hybrid Polymeric Micelles with Hydrophobic Cores and Mixed Polyelectrolyte/Nonelectrolyte Shells in Aqueous Media. 1. Preparation and Basic Characterization
Štěpánek, M., Podhájecká, K., Tesařová, E., Procházka, K., Tuzar, Z., & Brown, W. (2001) · Langmuir · doi:10.1021/la010246x · Cited by 87 · see citing works
Surface modification of poly(tetrafluoroethylene) films via grafting of poly(ethylene glycol) for reduction in protein adsorption
Wang, P., Tan, K. L., & Kang, E. T. (2000) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856200743634 · Cited by 86 · see citing works
Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion
Zhang, F., Kang, E. T., Neoh, K. G., & Huang, W. (2001) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856201300194252 · Cited by 83 · see citing works
Polylactide-poly(ethylene Glycol) Micellar-like Particles as Potential Drug Carriers: Production, Colloidal Properties and Biological Performance
Stolnik, S., Heald, C. R., Neal, J. C., Garnett, M. C., Davis, S. S., Illum, L., Purkiss, S. C., Barlow, R. J., & Gellert, P. R. (2001) · Journal of drug targeting · doi:10.3109/10611860108998772 · Cited by 82 · see citing works
Steric stabilization of liposomes by pH‐responsive N‐isopropylacrylamide copolymer
Roux, E., Stomp, R., Giasson, S., Pézolet, M., Moreau, P. R., & Leroux, J. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10172 · Cited by 73 · see citing works
Surface charge modulation of poly(ethylene glycol)–poly(d,l-lactide) block copolymer micelles: conjugation of charged peptides
Yamamoto, Y., Nagasaki, Y., Kato, M., & Kataoka, K. (1999) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00065-x · Cited by 71 · see citing works
In vitro dissociation of antifungal efficacy and toxicity for amphotericin B-loaded poly(ethylene oxide)-block-poly(β-benzyl-l-aspartate) micelles
Yu, B.-L., Okano, T., Kataoka, K., Sardari, S., & Kwon, G. S. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00095-9 · Cited by 65 · see citing works
Self-citation
Radioisotope carrying polyethylene oxide–polycaprolactone copolymer micelles for targetable bone imaging
Park, Y. J., Lee, J. Y., Chang, Y. S., Jeong, J. M., Chung, J. K., Lee, M. C., Park, K. B., & Lee, S. J. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00196-x · Cited by 57 · see citing works
An Adduct of cis-Diamminedichloroplatinum(II) and Poly(ethylene glycol)poly( l -lysine)−Succinate: Synthesis and Cytotoxic Properties
Bogdanov, A. A., Jr., Martin, C., Bogdanova, A., Brady, T. J., & Weissleder, R. (1996) · Bioconjugate Chemistry · doi:10.1021/bc950089b · Cited by 51 · see citing works
The effects of acyl chain length on the micelle properties of poly(ethylene oxide)-block-poly(N-hexylL-aspartamide)-acyl conjugates
Adams, M. L., & Kwon, G. S. (2002) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856202760319144 · Cited by 48 · see citing works
Self-citation
Determination of Critical Micelle Concentration of Anionic Surfactants: Comparison of Internal and External Fluorescent Probes
Goon, P., Manohar, C., & Kumar, V. (1997) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1997.4804 · Cited by 33 · see citing works
Preface: Overview of brain drug delivery
Pardridge, W. M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00002-o · Cited by 8 · see citing works
Association Colloids: Micelles, Vesicles, and Membranes
Myers, D. (2002) · doi:10.1002/0471234990.ch15 · Cited by 7 · see citing works
Untitled work
Taillefer (2000) · doi:10.1002/(sici)1520-6017(200001)89:1

Flagged first, then by citations

4 of the 90 references couldn’t be matched to a known paper.

Sorted by citations

Strategies in the design of nanoparticles for therapeutic applications
Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works
Therapeutic Nanoparticles for Drug Delivery in Cancer
Cho, K., Wang, X., Nie, S., Chen, Z. (., & Shin, D. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1441 · Cited by 2,919 · see citing works
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029 · see citing works
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,734 · see citing works
Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies
Ulbrich, K., Holá, K., Šubr, V., Bakandritsos, A., Tuček, J., & Zbořil, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00589 · Cited by 1,741 · see citing works
Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications
Albertsson, A.-C., & Varma, I. K. (2003) · Biomacromolecules · doi:10.1021/bm034247a · Cited by 1,582 · see citing works
Strategies to Address Low Drug Solubility in Discovery and Development
Williams, H. D., Trevaskis, N. L., Charman, S. A., Shanker, R. M., Charman, W. N., Pouton, C. W., & Porter, C. J. H. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005660 · Cited by 1,582 · see citing works
Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498 · see citing works
Block copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270 · see citing works
Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization
Sun, Q., Zhou, Z., Qiu, N., & Shen, Y. (2017) · Advanced Materials · doi:10.1002/adma.201606628 · Cited by 1,063 · see citing works
Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
Mundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.013 · Cited by 1,025 · see citing works
Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery
Rapoport, N. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.009 · Cited by 1,002 · see citing works
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
Oerlemans, C., Bult, W., Bos, M. A., Storm, G., Nijsen, J. F. W., & Hennink, W. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0233-4 · Cited by 951 · see citing works
Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 917 · see citing works
Advances in polymeric micelles for drug delivery and tumor targeting
Kedar, U., Phutane, P., Shidhaye, S., & Kadam, V. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.05.005 · Cited by 791 · see citing works
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy
Bae, Y., Nishiyama, N., Fukushima, S., Koyama, H., Yasuhiro, M., & Kataoka, K. (2005) · Bioconjugate Chemistry · doi:10.1021/bc0498166 · Cited by 742 · see citing works
Thermo-sensitive polymeric micelles based on poly (N-isopropylacrylamide) as drug carriers
Wei, H., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.05.002 · Cited by 718 · see citing works
Micellar carriers based on block copolymers of poly(ε-caprolactone) and poly(ethylene glycol) for doxorubicin delivery
Shuai, X., Ai, H., Nasongkla, N., Kim, S., & Gao, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.003 · Cited by 695 · see citing works
Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers
Bae, Y., & Kataoka, K. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.016 · Cited by 670 · see citing works
Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery
van Vlerken, L. E., Vyas, T. K., & Amiji, M. M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9284-6 · Cited by 646 · see citing works
PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation
Prencipe, G., Tabakman, S. M., Welsher, K., Liu, Z., Goodwin, A. P., Zhang, L., Henry, J. P., & Dai, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809086q · Cited by 602 · see citing works
Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
Xu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595 · see citing works
Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Klaikherd, A., Nagamani, C., & Thayumanavan, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809475a · Cited by 594 · see citing works
Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example
Torchilin, V. P. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_1 · Cited by 578 · see citing works
Poly(ethylene oxide)–poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs
Chiappetta, D. A., & Sosnik, A. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.03.022 · Cited by 570 · see citing works
Strategies to improve micelle stability for drug delivery
Lu, Y., Zhang, E., Yang, J., & Cao, Z. (2018) · Nano Research · doi:10.1007/s12274-018-2152-3 · Cited by 530 · see citing works
Polymeric nanomedicine for cancer therapy
Park, J. H., Lee, S., Kim, J.-H., Park, K., Kim, K., & Kwon, I. C. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.09.003 · Cited by 506 · see citing works
Functionalized carbon nanotubes: biomedical applications
Singh, S. R., Vardharajula, S., Tiwari, P. M., Eroğlu, E., Vig, K., Dennis, V. A., & Ali (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s35832 · Cited by 497 · see citing works
Poly(2-oxazolines) in biological and biomedical application contexts
Adams, N., & Schubert, U. S. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.018 · Cited by 492 · see citing works
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: An attractive tool for drug delivery
Rijcken, C. J. F., Soga, O., Hennink, W. E., & van Nostrum, C. F. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.023 · Cited by 487 · see citing works
Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies
Mandal, A., Bisht, R., Rupenthal, I. D., & Mitra, A. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.012 · Cited by 481 · see citing works
Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes
Ai, H., Flask, C., Weinberg, B., Shuai, X. ‐., Pagel, M. D., Farrell, D., Duerk, J., & Gao, J. (2005) · Advanced Materials · doi:10.1002/adma.200401904 · Cited by 465 · see citing works
Polymeric micelles for drug delivery
Aliabadi, H. M., & Lavasanifar, A. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.1.139 · Cited by 450 · see citing works
Self-citation
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery
Bae, Y., Jang, W., Nishiyama, N., Fukushima, S., & Kataoka, K. (2005) · Molecular BioSystems · doi:10.1039/b500266d · Cited by 445 · see citing works
Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin
Sun, H., Guo, B., Cheng, R., Meng, F., Liu, H., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.051 · Cited by 438 · see citing works
Polymeric surfactants for enhanced oil recovery: A review
Raffa, P., Broekhuis, A. A., & Picchioni, F. (2016) · Journal of Petroleum Science and Engineering · doi:10.1016/j.petrol.2016.07.007 · Cited by 424 · see citing works
Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives
Edis, Z., Wang, J., Waqas, M. K., Ijaz, M., & Ijaz, M. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s289443 · Cited by 401 · see citing works
Polymeric Surfactants: Synthesis, Properties, and Links to Applications
Raffa, P., Wever, D. A. Z., Picchioni, F., & Broekhuis, A. A. (2015) · Chemical Reviews · doi:10.1021/cr500129h · Cited by 390 · see citing works
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
Mesquita, M. Q., Dias, C. J., Gamelas, S. R. D., Fardilha, M., Neves, M. G. P. M. S., & Faustino, M. A. F. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720170800 · Cited by 381 · see citing works
pH- and ion-sensitive polymers for drug delivery
Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821978 · Cited by 367 · see citing works
Breast Cancer: Conventional Diagnosis and Treatment Modalities and Recent Patents and Technologies
Nounou, M. I., ElAmrawy, F., Ahmed, N., Abdelraouf, K., Goda, S., & Qhattal, H. S. S. (2015) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s29420 · Cited by 374 · see citing works
Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release
Chen, W., Zhong, P., Meng, F., Cheng, R., Deng, C., Feijén, J., & Zhong, Z. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.001 · Cited by 363 · see citing works
Construction of functional aliphatic polycarbonates for biomedical applications
Feng, J., Zhuo, R., & Zhang, X. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.07.008 · Cited by 358 · see citing works
Lactoferrin-conjugated PEG–PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations
Hu, K., Li, J., Shen, Y., Lü, W., Gao, X., Zhang, Q., & Jiang, X. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.016 · Cited by 354 · see citing works
Polymeric micelles to deliver photosensitizers for photodynamic therapy
VANNOSTRUM, C. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.07.013 · Cited by 342 · see citing works
Emerging nanopharmaceuticals
Bawarski, W. E., Chidlowsky, E., Bharali, D. J., & Mousa, S. A. (2008) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.06.002 · Cited by 342 · see citing works
Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
Salmaso, S., & Caliceti, P. (2013) · Journal of Drug Delivery · doi:10.1155/2013/374252 · Cited by 340 · see citing works
Nanoparticles as carriers for drug delivery in cancer
Dadwal, A., Baldi, A., & Narang, R. K. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1457039 · Cited by 344 · see citing works
A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems
Lu, H., Zhang, S., Wang, J., & Chen, Q. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.783831 · Cited by 336 · see citing works
Peptide-based biopolymers in biomedicine and biotechnology
Chow, D., Nunalee, M. L., Lim, D. W., Simnick, A. J., & Chilkoti, A. (2008) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2008.04.004 · Cited by 326 · see citing works
Shell-Sheddable Micelles Based on Dextran-SS-Poly(ε-caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin
Sun, H., Guo, B., Li, X., Cheng, R., Meng, F., Liu, H., & Zhong, Z. (2010) · Biomacromolecules · doi:10.1021/bm1001069 · Cited by 320 · see citing works
Polyoxyethylated nonionic surfactants and their applications in topical ocular drug delivery
Jiao, J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.002 · Cited by 314 · see citing works
Colloidal carriers and blood–brain barrier (BBB) translocation: A way to deliver drugs to the brain?
García-García, E., Andrieux, K., Gil, S., & Couvreur, P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.031 · Cited by 314 · see citing works
Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol
Chimento, A., Amicis, F. D., Sirianni, R., Sinicropi, M. S., Puoci, F., Casaburi, I., Saturnino, C., & Pezzi, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061381 · Cited by 314 · see citing works
Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy
Gindy, M. E., & Prud'homme, R. K. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902932908 · Cited by 298 · see citing works
Micelles structure development as a strategy to improve smart cancer therapy
Hanafy, N., El-Kemary, M., & Leporatti, S. (2018) · Cancers · doi:10.3390/cancers10070238 · Cited by 287 · see citing works
Nanomicelles: types, properties and applications in drug delivery
Bose, A., Roy Burman, D., Sikdar, B., & Patra, P. (2021) · IET Nanobiotechnology · doi:10.1049/nbt2.12018 · Cited by 278 · see citing works
Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery
Xiong, X.-B., Falamarzian, A., Garg, S. M., & Lavasanifar, A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.04.028 · Cited by 268 · see citing works
Self-citation
Advances in Platinum Chemotherapeutics
Harper, B. W. J., Krause‐Heuer, A. M., Grant, M. P., Manohar, M., Garbutcheon‐Singh, K. B., & Aldrich-Wright, J. R. (2010) · Chemistry - A European Journal · doi:10.1002/chem.201000148 · Cited by 267 · see citing works
Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems
Narmani, A., Rezvani, M., Farhood, B., Darkhor, P., Mohammadnejad, J., Amini, B., Refahi, S., & Goushbolagh, N. A. (2019) · Drug Development Research · doi:10.1002/ddr.21545 · Cited by 256 · see citing works
PEGylated polymers for medicine: from conjugation to self-assembled systems
Joralemon, M. J., McRae, S., & Emrick, T. S. (2010) · Chemical Communications · doi:10.1039/b920570p · Cited by 252 · see citing works
Different strategies to overcome multidrug resistance in cancer
Manju, S., & Gong, S. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.06.004 · Cited by 250 · see citing works
CD44-Targeted Nanocarrier for Cancer Therapy
Kesharwani, P., Chadar, R., Sheikh, A., Rizg, W. Y., & Safhi, A. Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.800481 · Cited by 248 · see citing works
Polymeric micelles: authoritative aspects for drug delivery
Kulthe, S. S., Choudhari, Y. M., Inamdar, N. N., & Mourya, V. (2012) · Designed Monomers and Polymers · doi:10.1080/1385772x.2012.688328 · Cited by 235 · see citing works
Simple Approach to Micropattern Cells on Common Culture Substrates by Tuning Substrate Wettability
Tan, J. L., Liu, W. F., Nelson, C. M., Raghavan, S., & Chen, C. S. (2004) · Tissue Engineering · doi:10.1089/1076327041348365 · Cited by 235 · see citing works
Immune system targeting by biodegradable nanoparticles for cancer vaccines
Silva, J. M., Videira, M., Gaspar, R. S., Véronique Préat, A., & Florindo, H. F. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.010 · Cited by 233 · see citing works
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
Martinelli, C., Pucci, C., & Ciofani, G. (2019) · APL Bioengineering · doi:10.1063/1.5079943 · Cited by 231 · see citing works
Targeted Nanomedicines: Effective Treatment Modalities for Cancer, AIDS and Brain Disorders
Muthu, M. S., & Singh, S. K. (2008) · Nanomedicine · doi:10.2217/17435889.4.1.105 · Cited by 224 · see citing works
Nanoencapsulation: A New Trend in Food Engineering Processing
Quintanilla‐Carvajal, M. X., Camacho‐Díaz, B. H., Meraz-Torres, L. S., Chanona‐Pérez, J. J., Alamilla‐Beltrán, L., Jiménez–Aparicio, A. R., & Gutiérrez‐López, G. F. (2009) · Food Engineering Reviews · doi:10.1007/s12393-009-9012-6 · Cited by 224 · see citing works
Polymeric micelles as a new drug carrier system and their required considerations for clinical trials
Yokoyama, M. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903436479 · Cited by 224 · see citing works
Biomaterials for the central nervous system
Zhong, Y., & Bellamkonda, R. V. (2008) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0071 · Cited by 221 · see citing works
Block copolymer micelles as delivery vehicles of hydrophobic drugs: Micelle–cell interactions
Savić, R., Eisenberg, A., & Maysinger, D. (2006) · Journal of Drug Targeting · doi:10.1080/10611860600874538 · Cited by 218 · see citing works
Polymers and nanoparticles: Intelligent tools for intracellular targeting?
Breunig, M., Bauer, S., & Göpferich, A. M. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.06.010 · Cited by 215 · see citing works
Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects
Mansour, H. M., Sohn, M., Al-Ghananeem, A. M., & DeLuca, P. P. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11093298 · Cited by 215 · see citing works
Formulation of Nanoparticles Using Mixing-Induced Nanoprecipitation for Drug Delivery
Liu, Y., Yang, G., Zou, D., Hui, Y., Nigam, K. D. P., Middelberg, A. P. J., & Zhao, C. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b04747 · Cited by 214 · see citing works
RAFT polymerization: an avenue to functional polymeric micelles for drug delivery
Stenzel, M. H. (2008) · Chemical Communications · doi:10.1039/b805464a · Cited by 212 · see citing works
Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
Wang, J., Seebacher, N. A., Shi, H., Kan, Q., & Duan, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.19187 · Cited by 209 · see citing works
Polymeric micelles as drug carriers: their lights and shadows
Yokoyama, M. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.934688 · Cited by 205 · see citing works
Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications
Kutikov, A. B., & Song, J. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00122 · Cited by 207 · see citing works
Shell-Cross-Linked Vesicles Synthesized from Block Copolymers of Poly( d , l -lactide) and Poly(N-isopropyl acrylamide) as Thermoresponsive Nanocontainers
Hales, M., Barner‐Kowollik, C., Davis, T. P., & Stenzel, M. H. (2004) · Langmuir · doi:10.1021/la0484016 · Cited by 205 · see citing works
Block copolymer micelles with acid-labile ortho ester side-chains: synthesis, characterization, and enhanced drug delivery to human glioma cells
Tang, R., Ji, W., Panus, D., Palumbo, R. N., & Wang, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.005 · Cited by 202 · see citing works
24-Fold Endohedral Functionalization of a Self-Assembled M12L24 Coordination Nanoball
Tominaga, M., Suzuki, K., Murase, T., & Fujita, M. (2005) · Journal of the American Chemical Society · doi:10.1021/ja054069o · Cited by 199 · see citing works
Ocular Drug Delivery to the Retina: Current Innovations and Future Perspectives
Kim, H. M., & Woo, S. J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010108 · Cited by 198 · see citing works
Non-destructive methods of characterization of risperidone solid lipid nanoparticles
Rahman, Z., Zidan, A. S., & Khan, M. A. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.05.003 · Cited by 197 · see citing works
Nano-therapeutics: A revolution in infection control in post antibiotic era
Zaidi, S., Misba, L., & Khan, A. U. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.06.015 · Cited by 194 · see citing works
CNS Drug Delivery Systems: Novel Approaches
Pathan, S., Iqbal, Z., Zaidi, S., Talegaonkar, S., Vohra, D., Jain, G., Azeem, A., Jain, N., Lalani, J., Khar, R., et al. (2009) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221109787158355 · Cited by 193 · see citing works
Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids
Xiao, F., Chen, Z., Wei, Z., & Tian, L. (2020) · Advanced Science · doi:10.1002/advs.202001048 · Cited by 193 · see citing works
Oral Bioavailability: Issues and Solutions via Nanoformulations
Pathak, K., & Raghuvanshi, S. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0242-x · Cited by 191 · see citing works
Assessment of the Integrity of Poly(caprolactone)-b-poly(ethylene oxide) Micelles under Biological Conditions: A Fluorogenic-Based Approach
Savić, R., Azzam, T., Eisenberg, A., & Maysinger, D. (2006) · Langmuir · doi:10.1021/la0531998 · Cited by 191 · see citing works
Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?
Kateb, B., Chiu, K., Black, K. L., Yamamoto, V. N., Khalsa, B., Ljubimova, J. Y., Ding, H., Patil, R., Portilla‐Arias, J., Modo, M., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.105 · Cited by 189 · see citing works
PEG- b -PLA micelles and PLGA- b -PEG- b -PLGA sol–gels for drug delivery
Cho, H., Gao, J., & Kwon, G. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.015 · Cited by 187 · see citing works
Self-citation
Toward the Emergence of Nanoneurosurgery: Part III—Nanomedicine: Targeted Nanotherapy, Nanosurgery, and Progress Toward the Realization of Nanoneurosurgery
Leary, S., Liu, C., & Apuzzo, M. (2006) · Neurosurgery · doi:10.1227/01.neu.0000217016.79256.16 · Cited by 113 · see citing works
Recent advances in theranostic polymeric nanoparticles for cancer treatment: A review
Indoria, S., Singh, V., & Hsieh, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119314 · Cited by 181 · see citing works
Nanotherapy for posterior eye diseases
Kaur, I. P., & Kakkar, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.031 · Cited by 175 · see citing works
Approaches for the preparation of non-linear amphiphilic polymers and their applications to drug delivery
Wang, Y., & Grayson, S. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.011 · Cited by 179 · see citing works
Composite Block Copolymer Stabilized Nanoparticles: Simultaneous Encapsulation of Organic Actives and Inorganic Nanostructures
Gindy, M. E., Panagiotopoulos, A. Z., & Prud’homme, R. K. (2007) · Langmuir · doi:10.1021/la702902b · Cited by 178 · see citing works
Distribution and Clearance of PEG-Single-Walled Carbon Nanotube Cancer Drug Delivery Vehicles in Mice
Bhirde, A. A., Patel, S., Sousa, A. A., Patel, V., Molinolo, A. A., Ji, Y., Leapman, R. D., Gutkind, J. S., & Rusling, J. F. (2010) · Nanomedicine · doi:10.2217/nnm.10.90 · Cited by 178 · see citing works

Significance of Amphiphilic Block Copolymer Micelles and its Characteristics
Joshi, T. (2017) · International Journal of Trend in Scientific Research and Development · doi:10.31142/ijtsrd2316 · Cited by 2 · see citing works
Amphiphilic block copolymer micelles for nanoscale drug delivery
Kwon, G. S., & Forrest, M. L. (2006) · Drug Development Research · doi:10.1002/ddr.20063 · Cited by 148 · see citing works
Self-citation
Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery
Xiong, X.-B., & Lavasanifar, A. (2011) · Fundamental biomedical technologies · doi:10.1007/978-94-007-1248-5_10 · Cited by 4 · see citing works
Self-citation
Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery
Xiong, X.-B., Falamarzian, A., Garg, S. M., & Lavasanifar, A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.04.028 · Cited by 268 · see citing works
Self-citation
ABC Micelles for Drug Delivery — Nanoscopic Vehicles for Potent Yet Toxic and Poorly Water-Soluble Compounds
Kwon, G. S. (2006) · International Conference on MEMS, NANO, and Smart Systems · doi:10.1109/icmens.2004.1508913
Self-citation

Authors: Adams, M. L., Lavasanifar, A., & Kwon, G. S.
Affiliations: University of Wisconsin–Madison (US)
University of Alberta (CA)
Corresponding author: Kwon, Glen S.
ORCID: Lavasanifar, Afsaneh
Kwon, Glen S.
Venue: Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2003-07
Volume: 92
Issue: 7
Pages: 1343-1355
ISSN: 0022-3549 (ISSN-L)
DOI: 10.1002/jps.10397
OpenAlex: W2002975193
Cited by: 1,078
References: 90
Citations by year: 2026: 18 · 2025: 26 · 2024: 33 · 2023: 54 · 2022: 60 · 2021: 47 · 2020: 56 · 2019: 66 · 2018: 51 · 2017: 51 · 2016: 69 · 2015: 68 · 2014: 62 · 2013: 60 · 2012: 63
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI 43346-02)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: amphiphilic block copolymers, polymeric micelles, drug delivery, poloxamer, micellization, critical micelle concentration, drug solubilization, pharmacokinetics, drug release profile, targeting moieties, circulation time, multidrug resistance
MeSH terms: Lactates, Polyethylene Glycols, Polymers, Surface-Active Agents, Drug Delivery Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Amphiphilic block copolymers for drug delivery

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks