Is acetaminophen as effective as an antihistamine–decongestant–acetaminophen combination in relieving symptoms of acute nasopharyngitis in children?
Abstract
Objectives To determine the efficiency of drugs, which include antihistaminic-decongestant-acetaminophen agents versus only acetaminophen in symptomatic treatment of acute nasopharyngitis in children. Methods This clinical, randomized, controlled, single blind drug efficacy comparison research was conducted in 148 patients with acute nasopharyngitis between ages 2 and 12 years. After randomization, Group-1 consisted of cases (n: 86), which used OTC drugs [acetaminophen+diphenhydramine+pseudoephedrin] and Group-2 consisted of cases (n: 62), which used only acetaminophen. After receiving nasal swab for showing the viral etiology, symptoms were scored clinically on admission and then on 10 days follow-up period, and re-evaluated on the third and fifth days of the drug therapy with the same scoring scale. Any complications were noted during the 1-month follow-up period after taking the drugs. Results The virus isolation rate in Group-1 was 27.9% and in Group-2 was 22.6%. At the first day of study, before medication, clinic scores of the groups did not show a significant difference (Group-1 1.7 versus Group-2 2.0). Clinic scores in both groups on the third (Group-1 4.0 versus Group-2 4.1) and fifth days of therapy (Group-1 1.7 versus Group-2 2.0) were not different either. Also, the complication rate was not different during the 1-month follow-up period (Group-1 2.3% versus Group-2 8.0%, p: 0.12). The family response for the drug satisfaction in both groups was similar and positiv…
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In Unuvar 2007, there was no meaningful difference in recovery rate.
“There was no meaningful difference in recovery rate.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
Three trials showed no effect of the antihistamine-decongestant-analgesic treatment on global effectiveness.
“Three trials showed no effect of the treatment.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
Five trials assessed the effect of the antihistamine-decongestant-analgesic combination on the subjective severity of nasal obstruction, and all showed some effect.
“Five trials assessed the effect of the antihistamine‐decongestant‐analgesic combination on the subjective severity of nasal obstruction, all of which showed some effect.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
The paediatric trial by Unuvar 2007 failed to show any effect on cough.
“In contrast, the paediatric trial by Unuvar 2007 failed to show any effect on cough.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
In Unuvar 2007, there was a significant difference in frequency of nasal stuffiness on the fifth day (P = 0.016), but not on the third day of therapy.
“In Unuvar 2007, there was a significant difference in frequency of nasal stuffiness on the fifth day (P = 0.016), but not on the third day of therapy.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
In Unuvar 2007, there were not significantly more children without rhinorrhoea on days three or five with the combination therapy in comparison with paracetamol.
“In contrast, in Unuvar 2007, there were not significantly more children without rhinorrhoea on days three or five with the combination therapy in comparison with paracetamol.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
In children there was no effect of the combination on cough.
“In children there was no effect.”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Unuvar 2007
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References 23 · Cited by 8
- Authors
- Unuvar, E., Yildiz, I., Kilic, A., Toprak, S., Aslan, S. S., Aydin, S., Badur, S., Oguz, F., & Sidal, M.
- Affiliations
- Istanbul University (TR)
- ORCID
- Badur, Selim
- Venue
- International Journal of Pediatric Otorhinolaryngology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 71
- Issue
- 8
- Pages
- 1277-1285
- ISSN
- 0165-5876 (ISSN-L)
- OpenAlex
- W155284745
- Cited by
- 8
- References
- 23
- Citations by year
- 2022: 1 · 2020: 1 · 2014: 1 · 2012: 3
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pediatric Otorhinolaryngology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
- Keywords
- acute nasopharyngitis, paracetamol, over-the-counter cold remedies, antihistamines, decongestants, diphenhydramine, pseudoephedrine, symptom relief, children, viral etiology
- MeSH terms
- Acetaminophen, Acute Disease, Child, Child, Preschool, Diphenhydramine, Drug Combinations, Nonprescription Drugs, Ephedrine, Female, Follow-Up Studies, Histamine H1 Antagonists, Humans, Male, Nasopharyngitis, Vasoconstrictor Agents, Nasal Decongestants, Analgesics, Non-Narcotic
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