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Cited by 18Prostate Cancer Diagnosis and TreatmentProstate Cancer Treatment and ResearchHormonal and reproductive studies

Effect of androgen suppression on hemoglobin in prostate cancer patients undergoing salvage radiotherapy plus 2-year buserelin acetate for rising PSA after surgery

Chander, Sarat, Choo, Richard, Danjoux, Cyril, Morton, Gerard, Pearse, Andrew, Deboer, Gerrit, Szumacher, Ewa, Loblaw, Andrew +2 more·2005·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2004.11.008
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Abstract

Purpose To examine the effect of 2-year androgen suppression (AS) on the pattern and extent of hemoglobin (Hb) change.Methods and materials The basis of this report was a Phase II study evaluating a combined treatment of salvage radiotherapy plus 2-year AS for a rising prostate-specific antigen level after surgery. Patients had laboratory tests performed, including Hb and serum testosterone, and answered a quality-of-life questionnaire (European Organization for Research and Treatment of Cancer Quality-of-life Questionnaire 30 item) at regular intervals during the AS and post-AS period. The pattern and extent of the change in Hb was analyzed in relation to the testosterone level. The clinical significance of the Hb change was evaluated with a correlation analysis between Hb and the three specific domains of the questionnaire (Global Health Status, Physical Functioning, and Fatigue).Results Of a total of 74 accrued patients, 69 were identified as eligible for this report. The median patient age was 70 years. The median follow-up was 38.6 months. The mean Hb was 150.7 g/L at baseline and declined with radiotherapy by 5.9 g/L. The maximal Hb drop during AS was 16.0 g/L (p <0.0001), occurring at 16 months after the initiation of AS. Hb recovery in the post-AS period was slow. The decline and recovery of the mean Hb and hematocrit followed that of testosterone. The three quality-of-life domains did not show any significant correlation with the change in Hb.Conclusion Two-year AS resulted in a statistically significant drop in the mean Hb, but had no clinically apparent adverse effect. The pattern of Hb change was similar to that of testosterone change.

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  • Circulating hemoglobin shows a progressive fall for 6 months reaching a nadir and plateau at 12 to 16 months in six studies involving 534 men undergoing medical castration for prostate cancer.

    “For example, circulating hemoglobin shows a progressive fall for 6 months reaching a nadir and plateau at 12 to 16 months in six studies involving 534 men undergoing medical castration for prostate cancer (179–184).”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [183]

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Authors
Chander, S., Choo, R., Danjoux, C., Morton, G., Pearse, A., Deboer, G., Szumacher, E., Loblaw, A., Cheung, P., & Woo, T.
Affiliations
Sunnybrook Health Science Centre (CA)
Corresponding author
Choo, Richard
ORCID
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2005-07
Volume
62
Issue
3
Pages
719-724
ISSN
0360-3016 (ISSN-L)
DOI
10.1016/j.ijrobp.2004.11.008
OpenAlex
W2123851975
Cited by
18
References
17
Citations by year
2025: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
androgen deprivation therapy, hemoglobin, prostate cancer, salvage radiotherapy, buserelin acetate, testosterone, anemia, hematocrit, quality of life, fatigue
MeSH terms
Aged, Buserelin, Fatigue, Health Status, Hematocrit, Hemoglobins, Humans, Male, Prostatectomy, Prostatic Neoplasms, Quality of Life, Testosterone, Salvage Therapy, Antineoplastic Agents, Hormonal

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