The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
High-Resolution, Small Animal Radiation Research Platform With X-Ray Tomographic Guidance Capabilities
Open accessAbstract
Purpose To demonstrate the CT imaging, conformal irradiation and treatment planning capabilities of a small animal radiation research platform (SARRP). Methods The SARRP employs a dual-focal spot, constant voltage x-ray source mounted on a gantry with a source-to-isocenter distance of 35 cm. Gantry rotation is limited to 120° from vertical. Eighty to 100 kVp x-rays from the smaller 0.4 mm focal spot are used for imaging. Both 0.4 mm and 3.0 mm focal spots operate at 225 kVp for irradiation. Robotic translate/rotate stages are used to position the animal. Cone-beam (CB) CT imaging is achieved by rotating the horizontal animal between the stationary x-ray source and a flat-panel detector. Radiation beams range from 0.5 mm in diameter to (60 × 60) mm2. Dosimetry is measured with radio-chromic films. Monte Carlo dose calculations are employed for treatment planning. The combination of gantry and robotic stage motions facilitate conformal irradiation. Results The SARRP spans 3 ft × 4 ft × 6 ft (WxLxH). Depending on filtration, the isocenter dose outputs at 1 cm depth in water range from 22 to 375 cGy/min from the smallest to the largest radiation fields. The 20% to 80% dose fall-off spans 0.16 mm. CBCT with (0.6 × 0.6 × 0.6) mm3 voxel resolution is acquired with less than 1 cGy. Treatment planning is performed at sub-mm resolution. Conclusions The capability of the SARRP to deliver highly focal beams to multiple animal model systems provides new research opportunities that more realistically bridge laboratory research and clinical translation.
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Self-citationNowak, E., Etienne, O., Millet, P., Lages, C. S., Mathieu, C., Mouthon, M., & Boussin, F. D. (2006) · Radiation Research · doi:10.1667/rr3496.1 · Cited by 77
Small Animal Radiation Research Platform: Imaging, Mechanics, Control and Calibration
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Self-citationEnhanced radiation response through directed molecular targeting approaches
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Self-citationSharabi, A. B., Nirschl, C. J., Kochel, C. M., Nirschl, T. R., Francica, B. J., Velarde, E., Deweese, T. L., & Drake, C. G. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0196 · Cited by 658
Self-citationZhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D.-X., Ford, E., et al. (2011) · Nature Medicine · doi:10.1038/nm.2268 · Cited by 526
Self-citationLander, V. E., Belle, J. I., Kingston, N. L., Herndon, J. M., Hogg, G. D., Liu, X., Kang, L.-I., Knolhoff, B. L., Bogner, S. J., Baer, J. M., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0192 · Cited by 114
Davis, C. M., Roma, P. G., Armour, E., Gooden, V. L., Brady, J. V., Weed, M. R., & Hienz, R. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104393 · Cited by 15
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Metadata
- Authors
- Wong, J., Armour, E., Kazanzides, P., Iordachita, I., Tryggestad, E., Deng, H., Matinfar, M., Kennedy, C., Liu, Z., Chan, T., Gray, O., Verhaegen, F., McNutt, T., Ford, E., & DeWeese, T. L.
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 71
- Issue
- 5
- Pages
- 1591-1599
- ISSN
- 0360-3016 (ISSN-L)
- OpenAlex
- W2044890358
- Cited by
- 364
- References
- 7
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Wong, J., Armour, E., Kazanzides, P., Iordachita, I., Tryggestad, E., Deng, H., Matinfar, M., Kennedy, C., Liu, Z., Chan, T., Gray, O., Verhaegen, F., McNutt, T., Ford, E., & DeWeese, T. L. (2008). High-Resolution, Small Animal Radiation Research Platform With X-Ray Tomographic Guidance Capabilities. International Journal of Radiation Oncology*Biology*Physics. https://doi.org/10.1016/j.ijrobp.2008.04.025
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