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Use of Normal Tissue Complication Probability Models in the Clinic
Open accessAbstract
The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.
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“A seminal paper by Emami et al. ( 6 ) summarized normal-tissue tolerances to external photon irradiation as they were known in 1991, and these data have been gradually updated and expanded through other initiatives such as Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and Hypofractionated Treatment Effects in the Clinic (HyTEC) ( 25 , 26 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [25]
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1 of the 30 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Jolles, 1939, Area factor in skin reaction, Br Emp Cancer Campaign Rep, 16
- Niemierko, 1999, A generalized concept of equivalent uniform dose (EUD), Med Phys, 26, 1100
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Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604
Chun, S. G., Hu, C., Choy, H., Komaki, R. U., Timmerman, R. D., Schild, S. E., Bogart, J. A., Dobelbower, M. C., Bosch, W. R., Galvin, J. M., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.69.1378 · Cited by 747
“The lung V20 is a classic and the most frequently described dosimetric parameter believed to be a threshold dose that predicts probability of lung injury.(29) However, a number of retrospective analyses have correlated radiation pneumonitis with low-dose baths, such as the V5.”
BackgroundHanania, A. N., Mainwaring, W., Ghebre, Y. T., Hanania, N. A., & Ludwig, M. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.03.033 · Cited by 645
Gay, H. A., Barthold, H. J., O’Meara, E., Bosch, W. R., Naqa, I. E., Al-Lozi, R., Rosenthal, S. A., Lawton, C. A., Lee, W. R., Sandler, H. M., et al. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2012.01.023 · Cited by 554
“Although the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) effort provided updated normal tissue dose constraints for various organs, guidance regarding normal organ contouring was absent (5).”
MethodRadiation therapy‐associated toxicity: Etiology, management, and prevention
Wang, K., & Tepper, J. E. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21689 · Cited by 473
Metadata
- Authors
- Marks, L. B., Yorke, E. D., Jackson, A., Ten Haken, R. K., Constine, L. S., Eisbruch, A., Bentzen, S. M., Nam, J., & Deasy, J. O.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Rochester Medicine (US)
- University of Michigan (US)
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- Corresponding author
- Marks, Lawrence B.
- ORCID
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 76
- Issue
- 3
- Pages
- S10-S19
- ISSN
- 0360-3016 (ISSN-L)
- PMC
- PMC4041542
- OpenAlex
- W2046701188
- Cited by
- 1,826
- References
- 30
- Citations by year
- 2026: 92 · 2025: 110 · 2024: 125 · 2023: 132 · 2022: 130 · 2021: 160 · 2020: 138 · 2019: 146 · 2018: 164 · 2017: 122 · 2016: 108 · 2015: 102 · 2014: 112 · 2013: 87 · 2012: 55
- FWCI
- 56.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Lance Armstrong Foundation
- Armstrong Foundation
- National Institutes of Health
- National Cancer Institute (CA69579, R29CA069579, R29CA085181, R01CA069579, R01CA129182, R01CA085181, CA85181)
- Topics
- Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- normal tissue complication probability, QUANTEC, normal tissue tolerance, NTCP models
- MeSH terms
- Adult, Child, Dose-Response Relationship, Radiation, Humans, Models, Biological, Organ Specificity, Radiation Injuries, Radiation Tolerance, Models, Statistical, Practice Guidelines as Topic, Radiation Oncology, Dose Fractionation, Radiation
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