Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG)

Wong, Jeffrey Y.C.; Filippi, Andrea Riccardo; Dabaja, Bouthaina Shbib; Yahalom, Joachim; Specht, Lena

doi:10.1016/j.ijrobp.2018.04.071

Cited by 220Effects of Radiation ExposureAdvanced Radiotherapy TechniquesHematopoietic Stem Cell Transplantation

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Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG)

Wong, Jeffrey Y.C., Filippi, Andrea Riccardo, Dabaja, Bouthaina Shbib, Yahalom, Joachim, Specht, Lena·2018·International Journal of Radiation Oncology*Biology*Physics

DOI 10.1016/j.ijrobp.2018.04.071

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Abstract

Total body irradiation (TBI) remains an effective myeloablative treatment in regimens used for preparation and conditioning before allogeneic stem cell transplantation for leukemia. The regimens used vary across institutions in terms of dose, dose rate, fractionation, and technique. The objective of this document is to provide comprehensive guidelines for the current practice of delivering total body irradiation.

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Before hematopoietic stem cell transplant in patients being treated for hematologic malignancies, common dose fractionation for myeloablation is 1.5 Gy to the whole body twice per day up to a total dose of 12.0-13.5 Gy.
“Before hematopoietic stem cell transplant in patients being treated for hematologic malignancies, common dose fractionation for myeloablation is 1.5 Gy to the whole body, twice per day, up to a total dose of 12.0 -13.5 Gy ( 90 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [90]

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Authors: Wong, J. Y. C., Filippi, A. R., Dabaja, B. S., Yahalom, J., & Specht, L.
Affiliations: City Of Hope National Medical Center (US)
University of Turin (IT)
The University of Texas MD Anderson Cancer Center (US)
Memorial Sloan Kettering Cancer Center (US)
University of Copenhagen (DK)
Corresponding author: Specht, Lena
ORCID: Wong, Jeffrey Y.C.
Filippi, Andrea Riccardo
Dabaja, Bouthaina Shbib
Yahalom, Joachim
Specht, Lena
Venue: International Journal of Radiation Oncology*Biology*Physics
Publisher: Elsevier BV
Published: 2018-07
Volume: 101
Issue: 3
Pages: 521-529
ISSN: 0360-3016 (ISSN-L)
DOI: 10.1016/j.ijrobp.2018.04.071
OpenAlex: W2799427821
Cited by: 220
References: 60
Citations by year: 2026: 24 · 2025: 21 · 2024: 32 · 2023: 28 · 2022: 36 · 2021: 40 · 2020: 21 · 2019: 16 · 2018: 2
FWCI: 3.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: total body irradiation, myeloablation, allogeneic stem cell transplantation, dose rate, fractionation, radiation techniques
MeSH terms: Humans, Lymphoma, Societies, Medical, Whole-Body Irradiation, Practice Guidelines as Topic, Internationality

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Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG)

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