Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis
Abstract
Objective To examine the effect of downregulation of high mobility group box 1 (HMGB1) on severe acute pancreatitis (SAP) associated with acute lung injury (ALI), and its subsequent effect on disease severity.Methods Wistar rats were given an IV injection of pRNA-U6.1/Neo-HMGB1, pRNA-U6.1/Neo-vector or saline before induction of SAP. Then, SAP was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. The control group received only a sham operation. Lung and pancreas samples were harvested after induction of SAP. The protein levels of HMGB1, matrix metalloproteinase-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) in lung tissue were investigated. The severity of pancreatic injury was determined by a histological score of pancreatic injury, serum amylase, and pancreatic water content. The lung injury was evaluated by measurement of pulmonary microvascular permeability, lung myeloperoxidase activity and malondialdehyde levels.Results The results found that in pRNA-U6.1/Neo-HMGB1 treated rats, serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels were decreased and the severity of pancreatic tissue injury was less compared with either untreated SAP or pRNA-U6.1/Neo-vector treated rats (P<0.05). The administration of pRNA-U6.1/Neo-HMGB1 in SAP-induced rats downregulated the DNA binding activity of the nuclear factor-kappa B (NF-κB) and the expressions of MMP-9 and ICAM-1 in lung. Thus, compared with the untreated SAP rats, the inflammatory response and the severity of ALI decreased (P<0.05).Conclusions These results demonstrate that HMGB1 could augment Inflammation by inducing nuclear translocation of NF-κB, thus aggratating the severity of SAP associated with ALI.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The downregulation of HMGB1 in hypoxia may signify cytoprotection from cellular damage, such as production of reactive oxygen species, as seen in normoxia cultures.
“Therefore, its downregulation in hypoxia may signify cytoprotection from cellular damage, such as production of reactive oxygen species, as seen in normoxia cultures [61, 62].”
From Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells (2018) · cites this paper as [61]
Cites
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386 · see citing works
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401 · see citing works
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434651100 · Cited by 1,126 · see citing works
HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2
Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832 · see citing works
Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation
Abraham, E. H., Arcaroli, J. J., Carmody, A., Wang, H., & Tracey, K. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.2950 · Cited by 692 · see citing works
Extracellular role of HMGB1 in inflammation and sepsis
Wang, H., Yang, H., & Tracey, K. J. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01302.x · Cited by 439 · see citing works
The ‘cytokine profile’: a code for sepsis
Ulloa, L., & Tracey, K. J. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.007 · Cited by 438 · see citing works
Activation of gene expression in human neutrophils by high mobility group box 1 protein
Park, J. S., Arcaroli, J. J., Yum, H.-K., Yang, H., Wang, H., Yang, K., Choe, K. H., Strassheim, D., Pitts, T. M., Tracey, K. J., et al. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00322.2002 · Cited by 433 · see citing works
Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury
Abraham, E. H., Carmody, A., Shenkar, R., & Arcaroli, J. J. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1137 · Cited by 403 · see citing works
Experimental Pancreatitis in the Rat
AHO, H. J., Koskensalo, S. M.-L., & Nevalainen, T. J. (1980) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528009181493 · Cited by 383 · see citing works
Contributions of High Mobility Group Box Protein in Experimental and Clinical Acute Lung Injury
Ueno, H., Matsuda, T., Hashimoto, S., Amaya, F., Kitamura, Y., Tanaka, M., Kobayashi, A., Maruyama, I., Yamada, S., Hasegawa, N., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-188oc · Cited by 356 · see citing works
Wang, H., Vishnubhakat, J. M., Bloom, O., Zhang, M., Ombrellino, M., Sama, A. E., & Tracey, K. J. (1999) · Surgery · doi:10.1016/s0039-6060(99)70182-0 · Cited by 298 · see citing works
The role of NF-κB activation in the pathogenesis of acute pancreatitis
Rakonczay, Z., Hegyi, P., Takács, T., McCarroll, J. A., & Saluja, A. K. (2007) · Gut · doi:10.1136/gut.2007.124115 · Cited by 257 · see citing works
HMGB1 contributes to the development of acute lung injury after hemorrhage
Kim, J. Y., Park, J. S., Strassheim, D., Douglas, I. S., del Valle, F. D., Asehnoune, K., Mitra, S., Kwak, S. H., Yamada, S., Maruyama, I., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00359.2004 · Cited by 250 · see citing works
Algül, H., Treiber, M., Lesina, M., Nakhai, H., Saur, D., Geisler, F., Pfeifer, A., Paxian, S. A., & Schmid, R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29882 · Cited by 194 · see citing works
Xie, K., Yu, Y., Huang, Y., Zheng, L., Li, J., Chen, H., Han, H.-Z., Hou, L., Gong, G., & Wang, G. (2012) · Shock · doi:10.1097/shk.0b013e31824ddc81 · Cited by 191 · see citing works
Keck, T., Balcom, J. H., del Castillo, C. F., Antoniu, B. A., & Warshaw, A. L. (2002) · Gastroenterology · doi:10.1053/gast.2002.30348 · Cited by 187 · see citing works
Models and mechanisms of acute lung injury caused by direct insults
Reiss, L. K., Uhlig, U., & Uhlig, S. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.11.004 · Cited by 172 · see citing works
Shenkar, R., & Abraham, E. H. (1999) · PubMed · Cited by 148 · see citing works
Differential effects between amphoterin and advanced glycation end products on colon cancer cells
Kuniyasu, H., Chihara, Y., & Kondo, H. (2003) · International Journal of Cancer · doi:10.1002/ijc.11016 · Cited by 141 · see citing works
Hemorrhage-induced acute lung injury is TLR-4 dependent
Barsness, K. A., Arcaroli, J. J., Harken, A. H., Abraham, E. H., Banerjee, A. M., Reznikov, L. L., & McIntyre, R. C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00412.2003 · Cited by 131 · see citing works
Shenkar, R., & Abraham, E. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.954 · Cited by 127 · see citing works
Early Cytokine Production Risk Stratifies Trauma Patients for Multiple Organ Failure
Jastrow, K. M., Gonzalez, E. A., McGuire, M. F., Suliburk, J. W., Kozar, R. A., Iyengar, S., Motschall, D., McKinley, B. A., Moore, F. A., & Mercer, D. (2009) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2009.05.002 · Cited by 118 · see citing works
Lung injury in acute pancreatitis: Mechanisms underlying augmented secondary injury
Elder, A. S. F., Saccone, G. T. P., & Dixon, D. (2012) · Pancreatology · doi:10.1016/j.pan.2011.12.012 · Cited by 73 · see citing works
Xu, H., Ye, X., Steinberg, H. N., & Liu, S. F. (2009) · The Journal of Pathology · doi:10.1002/path.2666 · Cited by 67 · see citing works
Gong, Q., Xu, J., Yin, H., Liu, S., Duan, L. ‐., & Bian, Z. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02194.x · Cited by 66 · see citing works
Severe acute pancreatitis: Case-oriented discussion of interdisciplinary management
Renzulli, P., Jakob, S. M., Täuber, M. G., Candinas, D., & Gloor, B. (2005) · Pancreatology · doi:10.1159/000085266 · Cited by 57 · see citing works
Hartwig, W., Werner, J., Warshaw, A. L., Antoniu, B. A., Castillo, C. F. F.-D., Gebhard, M. M., Uhl, W. H., & Büchler, M. W. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00221.2004 · Cited by 41 · see citing works
Chen, P., Zhang, Y., Qiao, M.-M., & Yuan, Y. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2104-2 · Cited by 39 · see citing works
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
Shang, G.-H., Lin, D., Xiao, W. L., Jia, C.-Q., Li, Y., Wang, A., & Dong, L. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-91 · Cited by 36 · see citing works
Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice
Lau, H. Y., & Bhatia, M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00429.2006 · Cited by 35 · see citing works
Zinc Aspartate Alleviates Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats
Türüt, H., Kurutaş, E. B., Bülbüloğlu, E., Yasım, A., Özkaya, M., Onder, A., & Imrek, S. S. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.01.004 · Cited by 32 · see citing works
ACTIVATED PROTEIN C ATTENUATES LEUKOCYTE ELASTASE-INDUCED LUNG INJURY IN MICE
Tanaka, A., Minoguchi, K., Chen, X., Oda, N., Yokoe, T., Yamamoto, Y., Yamamoto, M., Watanabe, Y., Ohta, S., Xu, X., et al. (2008) · Shock · doi:10.1097/shk.0b013e31815dd570 · Cited by 29 · see citing works
Solan, P. D., Piraino, G., Hake, P. W., Denenberg, A. G., O’Connor, M. P., Lentsch, A. B., & Zingarelli, B. (2010) · Shock · doi:10.1097/shk.0b013e3181f7d742 · Cited by 29 · see citing works
Zhang, X. P., Zhang, L., Xu, H. M., Xu, Y., Cheng, Q. H., Wang, J. M., & Shen, H. P. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9867-4 · Cited by 18 · see citing works
Self-citationDu, X., Chen, X., Gan, H., Li, Z.-R. T., Wen, Y.-J., & Wang, X.-C. (2011) · The International Journal of Artificial Organs · doi:10.5301/ijao.2011.7742 · Cited by 12 · see citing works
Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis
Zhao, X., Shi, C., Wang, X., & Andersson, R. E. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.07.005 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ge, P., Luo, Y., Okoye, C. S., Chen, H., Liu, J., Zhang, G., Xu, C., & Chen, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110770 · Cited by 247 · see citing works
Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
Antebi, B., Rodriguez, L. A., Walker, K. P., Asher, A. M., Kamucheka, R. M., Alvarado, L., Mohammadipoor, A., & Cancio, L. C. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1007-x · Cited by 137 · see citing works
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis
Ferrero-Andrés, A., Rosello, A. P., Roselló‐Catafau, J., & Folch‐Puy, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155386 · Cited by 91 · see citing works
DAMPs and sterile inflammation in drug hepatotoxicity
Yang, R., & Tonnesseen, T. I. (2018) · Hepatology International · doi:10.1007/s12072-018-9911-9 · Cited by 90 · see citing works
Li, G., Wu, X., Yang, L. J., He, Y., LIU, Y., Jin, X., & Yuan, H. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2410 · Cited by 88 · see citing works
Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine
Moreno‐González, G., Vandenabeele, P., & Krysko, D. V. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201510-2106ci · Cited by 86 · see citing works
Yang, R., Zou, X., Tenhunen, J. J., & Tønnessen, T. I. (2017) · Mediators of Inflammation · doi:10.1155/2017/5928078 · Cited by 72 · see citing works
The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
Liu, D., Wen, L., Wang, Z., Hai, Y., Yang, D., Zhang, Y., Bai, M., Song, B., & Wang, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.904078 · Cited by 70 · see citing works
Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
Yang, R., Zhu, S., & Tønnessen, T. I. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0144-1 · Cited by 69 · see citing works
High-mobility group box 1 protein and its role in severe acute pancreatitis
Shen, X. L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1424 · Cited by 61 · see citing works
Yang, R., Tenhunen, J. J., & Tønnessen, T. I. (2017) · International Journal of Inflammation · doi:10.1155/2017/1817564 · Cited by 59 · see citing works
Taguchi, K., Nagao, S., Maeda, H., Yanagisawa, H., Sakai, H., Yamasaki, K., Wakayama, T., Watanabe, H., Otagiri, M., & Maruyama, T. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1477860 · Cited by 52 · see citing works
Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis
Zhou, X., Jin, S., Pan, J., Lin, Q., Yang, S., Ambe, P. C., Basharat, Z., Zimmer, V., Wang, W., & Hong, W. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.927193 · Cited by 51 · see citing works
MicroRNAs in acute pancreatitis: From pathogenesis to novel diagnosis and therapy
Yang, Y., Huang, Q., Luo, C., Wen, Y., Liu, R., Sun, H., & Tang, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29212 · Cited by 49 · see citing works
Zhang, T., Xia, M., Zhan, Q., Zhou, Q., Lu, G., & An, F. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3586-z · Cited by 44 · see citing works
Abdelmageed, M. E., Nader, M. A., & Zaghloul, M. S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174279 · Cited by 42 · see citing works
Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice
Yang, R., Zhu, S., Pischke, S. E., Haugaa, H., Zou, X., & Tønnessen, T. I. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.02.049 · Cited by 34 · see citing works
PKR suppress NLRP3-pyroptosis pathway in lipopolysaccharide-induced acute lung injury model of mice
Zeng, Y., Qin, Q., Li, K., Li, H., Song, C., Li, Y., Dai, M., Lin, F., Mao, Z., Li, Q., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.054 · Cited by 33 · see citing works
Wu, X., Ji, K., Wang, H., Yang, Z., Jia, J., Gao, X., & Zang, B. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26859 · Cited by 29 · see citing works
RetractedExogenous surfactant prevents hyperoxia-induced lung injury in adult mice
Bezerra, F. S., Ramos, C. D. O., Castro, T. D. F., Araújo, N. P. D. S., de Souza, A. B. F., Bandeira, A. C. B., Costa, G. D. P., Cartelle, C. T., Talvani, A., Cangussú, S. D., et al. (2019) · Intensive Care Medicine Experimental · doi:10.1186/s40635-019-0233-6 · Cited by 29 · see citing works
Yu, C., Merza, M., Luo, L., & Thorlacius, H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.020 · Cited by 27 · see citing works
Zhu, R., Zhao, Y., Li, X., Bai, T., Wang, S., Wang, W., & Sun, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.025 · Cited by 26 · see citing works
RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis
Li, X., Lin, Z., Wang, L., Liu, Q., Cao, Z., Huang, Z., Zhong, M., Peng, S., Zhang, Y., Li, Y., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495866 · Cited by 25 · see citing works
Self-citationLi, L., Liu, M., Zhang, T., Jia, Y., Zhang, Y., Yuan, H., Zhang, G., & He, C. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2019.1623306 · Cited by 25 · see citing works
Chronic Pancreatitis Associated Acute Respiratory Failure
Anil, M. (2017) · MOJ Immunology · doi:10.15406/moji.2017.05.00149 · Cited by 21 · see citing works
CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis
Lv, C., He, Y., Wei, M., Xu, G., Chen, C., Xu, Z., & Ding, Z. (2020) · Bioscience Reports · doi:10.1042/bsr20200092 · Cited by 21 · see citing works
Zhu, C.-J., Yang, W.-G., Li, D.-J., Song, Y., Chen, S., Wang, Q., Liu, Y.-N., Zhang, Y., Cheng, B., Wu, Z.-W., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i44.7669 · Cited by 20 · see citing works
Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis
Wang, S. Y., Li, Z.-Z., Wang, X., Li, W. F., & Lin, Z. (2015) · Genetics and Molecular Research · doi:10.4238/2015.april.30.7 · Cited by 19 · see citing works
Pan, L., Yu, L., Wang, L., He, J.-T., Sun, J., Wang, X.-B., Wang, H., Bai, Z.-H., Feng, H., & Pei, H. (2018) · PubMed Central · Cited by 19 · see citing works
Ketamine effect on HMGB1 and TLR4 expression in rats with acute lung injury.
Qin, M., Gu, Q.-H., Tao, J., Song, X., Gan, G., Zhong-bin, L., & Li, B. (2015) · PubMed Central · Cited by 17 · see citing works
Xianghua, G., Guo, R., Luo, X., & Zhou, L. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.015 · Cited by 17 · see citing works
Self-citationInflammatory profiling of early experimental necrotizing pancreatitis
Schneider, L., Jabrailova, B., Strobel, O., Hackert, T., & Werner, J. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.029 · Cited by 16 · see citing works
HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling.
Wang, H., Peng, L., Chen, W., Tang, S.-H., Sun, B., Wang, H., Huang, R., Xu, Z., & Lei, W.-F. (2014) · PubMed Central · Cited by 16 · see citing works
Lv, P., Li, H., Ji, S., Wen, L., & Fan, L. (2014) · Pathology - Research and Practice · doi:10.1016/j.prp.2014.04.022 · Cited by 16 · see citing works
The Pathogenesis of Pancreatitis and the Role of Autophagy
Tsomidis, I., Voumvouraki, A., & Kouroumalis, E. (2024) · Gastroenterology Insights · doi:10.3390/gastroent15020022 · Cited by 12 · see citing works
Swetha, K., Indumathi, M. C., Kishan, R. S., Siddappa, S., Chen, C., & Marathe, G. K. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04531-2 · Cited by 12 · see citing works
Lin, Y., Lin, L., Yu, J. H., Cao, Y., Zhang, Y., Zheng, C., Liu, J.-L., & Yang, S.-L. (2015) · BioMed Research International · doi:10.1155/2015/430185 · Cited by 11 · see citing works
RetractedFighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury
Yang, Q., Luo, Y., Lan, B., Dong, X., Wang, Z., Ge, P., Zhang, G., & Chen, H. (2022) · Bioengineering · doi:10.3390/bioengineering9110615 · Cited by 10 · see citing works
Jiao, P., Wang, Y., Ren, G., Chu, D., Li, Y., Yang, Y., & Sang, T. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-02977-0 · Cited by 10 · see citing works
Meng, Y.-T., Sha, S., Yang, J., & Ren, H. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05524-7 · Cited by 9 · see citing works
ZHANG, X., LUAN, Z., LIANG, Y., LIU, Y., & MA, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3251 · Cited by 8 · see citing works
Self-citationChen, Z., Zheng, R., Jiang, H., Zhang, X., Peng, M., Jiang, T., Zhang, X., & Shang, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156629 · Cited by 8 · see citing works
Self-citationStimulation of Central α2 Receptors Attenuates Experimental Necrotizing Pancreatitis
Schneider, L., Jabrailova, B., Salem, M., Kilk, K., Hofer, S., Brenner, T., Strobel, O., Hackert, T., & Werner, J. (2015) · Pancreas · doi:10.1097/mpa.0000000000000474 · Cited by 7 · see citing works
DGA ameliorates severe acute pancreatitis through modulating macrophage pyroptosis
Yue, X., Lai, L., Wang, R., Tan, L., Wang, Y., Xie, Q., & Li, Y. (2024) · Inflammation Research · doi:10.1007/s00011-024-01931-3 · Cited by 6 · see citing works
Obeng, E., Ergashev, A., Yao, Q., Wu, W., & Chen, G. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s514653 · Cited by 4 · see citing works
Zhang, F., Hao, H., Liu, Y., Fan, K.-L., Dai, W., Liu, W., & Kong, L. (2021) · doi:10.21203/rs.2.24775/v3 · Cited by 4 · see citing works
Zhang, F., Hao, H., Liu, Y., Fan, K.-L., Dai, W., Liu, W., & Kong, L. (2020) · doi:10.21203/rs.2.24775/v2 · Cited by 3 · see citing works
Fernández‐Barrena, M. G., & Pin, C. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00020-4 · Cited by 2 · see citing works
Zhang, F., Hao, H., Liu, Y., Fan, K.-L., Dai, W., Liu, W., & Kong, L. (2020) · doi:10.21203/rs.2.24775/v1 · Cited by 2 · see citing works
Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury
Ono, N., Horikoshi, J., Izawa, T., Nishiyama, K., Tanaka, M., Fujita, T., Kuwamura, M., & Azuma, Y.-T. (2023) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.23-0094 · Cited by 1 · see citing works
High mobility group box protein-1 (HMGB1) level in gallstones patients
Mohammed, S. H., Al-Dujaili, A. N., & Katib, W. A. E. (2022) · AIP conference proceedings · doi:10.1063/5.0093559 · Cited by 1 · see citing works
Ion Flux Regulates Inflammasome Signaling
Yaron, J. R. (2015) · doi:10.13140/rg.2.2.32297.60007
Emodin diminishes immune stress in rats with severe acute pancreatitis
Jin, W., Zhang, X., Chen, Q., Tian, J., Zhu, Y., & Shen, Y. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-18-409
Self-citationEffects of Daphnetin on Experimental Acute Pancreatitis-Associated Acute Lung Injury in Mice
Chen, T., Chen, O., Zhao, M., & chen, X. (2023) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1155/2023/9822900
甘, 小. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1541320
Wang, Y.-M., Wang, W.-T., Liang, J.-Y., Xu, W., Li, H.-Y., Gao, Y.-T., & Wang, H. (2026) · Scientific Reports · doi:10.1038/s41598-026-55400-4
Saleh, A., Ghazal‐Aswad, K., Fernandez-Barrena, M. G., & Pin, C. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-19001-8.00025-8
- Authors
- Luan, Z.-G., Zhang, X.-J., Yin, X.-H., Ma, X.-C., Zhang, H., Zhang, C., & Guo, R.-X.
- Affiliations
- First Hospital of China Medical University (CN)
- General Hospital of Shenyang Military Region (CN)
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 218
- Issue
- 10
- Pages
- 1261-1270
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2070531069
- Cited by
- 59
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 11 · 2014: 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- HMGB1, severe acute pancreatitis, acute lung injury, RNA interference, NF-κB nuclear translocation, MMP-9, ICAM-1, inflammatory cytokines, TNF-α, IL-1β, lung inflammation, oxidative stress, sodium taurocholate-induced pancreatitis
- MeSH terms
- Animals, Lung, Male, Protein Binding, Taurocholic Acid, Tumor Necrosis Factor-alpha, Down-Regulation, NF-kappa B, Rats, Wistar, Disease Progression, Intercellular Adhesion Molecule-1, Pancreatitis, Acute Necrotizing, Matrix Metalloproteinase 9, HMGB1 Protein, RNA, Small Interfering, Rats, Interleukin-1beta, Acute Lung Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review