Cited by 313Immune cells in cancerinterferon and immune responsesMacrophage Migration Inhibitory Factor

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The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

Chistiakov, Dimitry A., Myasoedova, Veronika A., Revin, Victor V., Orekhov, Alexander N., Bobryshev, Yuri V.·2018·Immunobiology

DOI 10.1016/j.imbio.2017.10.005

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Abstract

The mononuclear phagocytes control the body homeostasis through the involvement in resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental changes can significantly influence the functional behavior of monocytes and macrophages. Such microenvironmental changes for example occur in an atherosclerotic plaque during all progression stages. In response to exogenous stimuli, macrophages show a great phenotypic plasticity and heterogeneity. Exposure of monocytes to inflammatory or anti-inflammatory conditions also induces predominant differentiation to proinflammatory (M1) or anti-inflammatory (M2) macrophage subsets and phenotype switch between macrophage subsets. The phenotype transition is accompanied with great changes in the macrophage transcriptome and regulatory networks. Interferon-regulatory factors (IRFs) play a key role in hematopoietic development of monocytes, their differentiation to macrophages, and regulating macrophage maturation, phenotypic polarization, phenotypic switch, and function. Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF-3 and IRF-4 control M2 polarization. The role of IRF-2 is context-dependent. The IRF impact on macrophage phenotype plasticity and heterogeneity is complex and involves activating and repressive function in triggering transcription of target genes.

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Additional file 1 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
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Additional file 2 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
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Additional file 3 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
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Additional file 8 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L.-X., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Jianyong, D. (2022) · Figshare · doi:10.6084/m9.figshare.21301413
Additional file 1 of Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623217
Additional file 7 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L.-X., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301410
Additional file 2 of Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623223
Additional file 7 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204374
Additional file 1 of Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration
Sun, X., Sun, P., Liu, L., Jiang, P., & Li, Y. (2021) · Figshare · doi:10.6084/m9.figshare.13532042
Additional file 5 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204365
Additional file 1 of BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats
Li, Z., Li, Q., Tong, K., Zhu, J., Wang, H., Chen, B., & Chen, L. (2022) · Figshare · doi:10.6084/m9.figshare.20329429
Additional file 2 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204356
Additional file 10 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L.-X., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301383
Additional file 12 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L., Deng, J., Wang, S., Wang, H.-K., Jiang, J., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301389
Additional file 11 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L., Deng, J., Wang, S., Wang, H.-K., Jiang, J., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301386
Additional file 3 of Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis
Marini, C., Cossu, V., Bonifacino, T., Bauckneht, M., Torazza, C., Bruno, S., Castellani, P., Ravera, S., Milanese, M., Venturi, C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12623226
Additional file 6 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204371
Additional file 4 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L.-X., Deng, J., Wang, S., Wang, H.-K., Jiang, J., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301401
Additional file 4 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204362
Additional file 5 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L.-X., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301404
Additional file 1 of Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization
Xia, W., Lu, Z., Chen, W., Zhou, J., & Zhao, Y. (2022) · Figshare · doi:10.6084/m9.figshare.19204350
Additional file 9 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301416
Additional file 6 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1
Gao, J., Ao, Y., Zhang, L., Deng, J., Wang, S., Wang, H.-K., Jiang, J.-H., & Ding, J.-Y. (2022) · Figshare · doi:10.6084/m9.figshare.21301407

Authors: Chistiakov, D. A., Myasoedova, V. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V.
Affiliations: Federal Medical Research Centre for Psychiatry and Narcology (RU)
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
UNSW Sydney (AU)
Corresponding author: Bobryshev, Yuri V.
ORCID: Chistiakov, Dimitry A.
Myasoedova, Veronika A.
Orekhov, Alexander N.
Bobryshev, Yuri V.
Venue: Immunobiology
Publisher: Elsevier BV
Published: 2018-01
Volume: 223
Issue: 1
Pages: 101-111
ISSN: 0171-2985 (ISSN-L)
DOI: 10.1016/j.imbio.2017.10.005
OpenAlex: W2764291671
Cited by: 311
References: 151
Citations by year: 2026: 15 · 2025: 37 · 2024: 29 · 2023: 41 · 2022: 58 · 2021: 48 · 2020: 27 · 2019: 40 · 2018: 16
FWCI: 2.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Immunobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Russian Science Foundation (#14-15-00112)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: interferon regulatory factors, macrophage polarization, M1 macrophages, M2 macrophages, macrophage differentiation, monocyte differentiation, macrophage heterogeneity, macrophage plasticity, IRF1, IRF5, IRF8, IRF3, IRF4, IRF2, atherosclerosis, tissue microenvironment, wound healing
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Macrophages, Cytokines, Th1 Cells, Th2 Cells, Interferon Regulatory Factors, Cell Transdifferentiation

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The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

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