Critical roles of the PI3K/Akt signaling pathway in T cell development
Open accessAbstract
Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stage to the CD4+CD8+ (double positive) stage. The PI3K/Akt signaling pathway is required to translate these extracellular signaling events into multiple functional outcomes including cellular survival, proliferation, differentiation, and allelic exclusion at the beta-selection checkpoint. However, a complete understanding of the contributions made by the PI3K/Akt pathway in thymocyte development has not been straightforward. This review highlights studies that support the model that the PI3K/Akt pathway is essential for thymocyte survival. We provide new evidence that Akt-mediated survival is not solely due to the increased expression of Bcl-xL but also is a consequence of the role played by Akt to support metabolism in proliferating thymocytes.
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Akt signalling pathway is up-regulated in lymphocytes.
“Second, Akt signalling pathway is up-regulated in lymphocytes [148].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [148]
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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works
Careaga, M., Noyon, T., Basuta, K., Van de Water, J., Tassone, F., Hagerman, R. J., & Ashwood, P. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-110 · Cited by 20 · see citing works
- Authors
- Juntilla, M. M., & Koretzky, G. A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 116
- Issue
- 2
- Pages
- 104-110
- ISSN
- 0165-2478 (ISSN-L)
- PMC
- PMC2322870
- OpenAlex
- W2061149209
- Cited by
- 147
- References
- 0
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 7 · 2012: 15
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (F31 A1056671)
- National Cancer Institute (P01CA093615)
- National Institute of General Medical Sciences (R01GM053256)
- National Institute of Allergy and Infectious Diseases (R01AI058019)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- PI3K/Akt signaling, T cell development, T cell lineage commitment, pre-TCR signaling, Notch signaling, CD127, beta-selection, allelic exclusion, thymocyte survival, Bcl-xL, cell proliferation
- MeSH terms
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Animals, Cell Differentiation, T-Lymphocytes, Signal Transduction, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt
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