Autoantibodies in chronic obstructive pulmonary disease: A systematic review
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of death worldwide in which the involvement of autoimmunity has been widely investigated and debated. The role of autoantibodies in COPD has been extensively researched in recent years. The aim of this systematic review is to assess the association between autoantibodies and COPD and analyse whether autoantibody levels correlate with disease severity and/or phenotype. PubMed, Embase, OpenGrey and the reference lists of articles were searched. The strongest evidence for an association between autoantibodies and COPD lies with anti-endothelial/epithelial cell autoantibodies (7 studies, all positive), rheumatoid factor autoantibodies (4 studies, all positive), anti-cytokeratin autoantibodies (3 studies, all positive), anti-nuclear autoantibodies (8 studies, 7 positive) and anti-collagen autoantibodies (10 studies, 6 positive). This review also identifies several other autoantibodies which had both positive and negative associations with COPD, however the evidence for these was not as strong and/or the number of studies is low, and further research is required. In particular, a clear case can be made for the potential importance of autoantibodies to carbonylated proteins. The relationship between autoantibody levels and disease severity requires further research with only 17/43 studies investigating this; however, 12 of the studies did show a positive association, making it a promising area for future research. There was also not enough evidence available on the relationship between autoantibody levels and disease phenotype to draw any conclusions, with only 2 studies investigating it (1 positive and 1 negative). This review has shown very promising evidence for the association of several autoantibodies in COPD and has identified those autoantibodies which require further research.
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Various autoantibodies against epithelial cells and against collagen have been reported in COPD patients, which increases disorder severity.
“Various autoantibodies against epithelial cells and against collagen have been reported in COPD patients which in turn increases disorder severity (Byrne et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Byrne et al. 2019
Autoimmunity plays a role in promoting COPD.
“Autoimmunity, a failure of the body’s immune system plays a role in promoting COPD.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Byrne et al. 2019
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- Authors
- Byrne, R., Todd, I., Tighe, P. J., & Fairclough, L. C.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Fairclough, Lucy C.
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 214
- Pages
- 8-15
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W2970119843
- Cited by
- 23
- References
- 54
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- chronic obstructive pulmonary disease, autoantibodies, autoimmunity, rheumatoid factor, antinuclear antibodies, protein carbonyls, disease severity, disease phenotypes
- MeSH terms
- Antibody Specificity, Autoantibodies, Autoantigens, Epithelial Cells, Humans, Pulmonary Disease, Chronic Obstructive
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