The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Open accessAbstract
Inflammatory bowel disease (IBD) is thought to result from a dysregulated interaction between the host immune system and its commensal microflora. Heterogeneity of disease susceptibility in humans and rodents suggest that multiple mechanisms are responsible for the etiology of IBD. In particular, deficiencies in anti-inflammatory and immune-suppressive mechanisms play an important role in the development of IBD. However, it is unknown how the indigenous microflora stimulates the immune system and how this response is regulated. To address these questions, we investigated the role of Toll-like receptor (TLR) signaling in the development of spontaneous, commensal-dependent colitis in interleukin (IL)-2- and IL-10-deficient mice. We report that colitis was dependent on TLR signaling in Il10(-/-) mice. In contrast, Il2(-/-) mice developed intestinal inflammation in the absence of TLR signaling pathways. These results demonstrate a differential role of innate immune recognition by TLRs in the development of commensal-dependent colitis.
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1 retracted
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Interleukin-10-deficient mice develop chronic enterocolitis
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
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Self-citationToll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,193
Self-citationInterleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature Reviews Immunology · doi:10.1038/nri1001 · Cited by 3,927
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
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MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
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Cited by
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
Terzić, J., Grivennikov, S., Karin, E., & Karin, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.058 · Cited by 1,974
Gut microbiota and IBD: causation or correlation?
Ni, J., Wu, G. D., Albenberg, L., & Tomov, V. T. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.88 · Cited by 1,778
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598
SOCS proteins, cytokine signalling and immune regulation
Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2093 · Cited by 1,580
Metadata
- Authors
- Rakoff-Nahoum, S., Hao, L., & Medzhitov, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 25
- Issue
- 2
- Pages
- 319-329
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2089800177
- Cited by
- 344
- References
- 56
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. (2006). Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis. Immunity. https://doi.org/10.1016/j.immuni.2006.06.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
