The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity
Open accessAbstract
Summary Although T helper 17 (Th17) cells have been found in human tumor tissues, their function in cancer immunity is unclear. Here we show that IL-17-deficient mice were more susceptible to the development of lung melanoma. Conversely, adoptive T cell therapy with tumor-specific Th17 cells prevented tumor development. Importantly, the donor Th17 cells retained their cytokine expression phenotype and exhibited stronger therapeutic efficacy than Th1 cells. Unexpectedly, therapy using Th17 but not Th1 cells elicited a remarkable activation of tumor-specific CD8+ T cells, which were necessary for the anti-tumor effect. Th17 cells promoted dendritic cell recruitment into the tumor tissues and greatly increased the numbers of CD8α+ dendritic cells containing tumor materials in draining lymph nodes. Moreover, compared to Th1 cells, Th17 cells promoted CCL20 chemokine production in tumor tissues and tumor-bearing CCR6-deficient mice were completely impaired in responding to Th17 therapy. Our data indicate that Th17 cells elicit a protective inflammation that ultimately promotes the activation of tumor-specific CD8+ T cells. These findings have important implications in anti-tumor immunotherapies.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Self-citationIL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
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Self-citationTH17 cells in development: an updated view of their molecular identity and genetic programming
Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064
Self-citationIL-23 promotes tumour incidence and growth
Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature · doi:10.1038/nature04808 · Cited by 1,018
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing
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Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
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Self-citationGeneration and regulation of human CD4 + IL-17-producing T cells in ovarian cancer
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Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688
Self-citationFunctional Specialization of Interleukin-17 Family Members
Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289
The polarization of immune cells in the tumour environment by TGFβ
Flavell, R. A., Sanjabi, S., Wrzesinski, S. H., & Licona-Limón, P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2808 · Cited by 940
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Metadata
- Authors
- Martin-Orozco, N., Muranski, P., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 31
- Issue
- 5
- Pages
- 787-798
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2068119757
- Cited by
- 800
- References
- 8
- FWCI
- 24.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Martin-Orozco, N., Muranski, P., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C. (2009). T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity. Immunity. https://doi.org/10.1016/j.immuni.2009.09.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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