TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, Chen

doi:10.1038/nri2295

Cited by 1,064Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, Chen·2008·Nature reviews. Immunology

DOI 10.1038/nri2295

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Abstract

Following activation, CD4+ T cells differentiate into different lineages of helper T (T(H)) cells that are characterized by distinct developmental regulation and biological functions. T(H)17 cells have recently been identified as a new lineage of effector T(H) cells, and they have been shown to be important in immune responses to infectious agents, as well as in various immune diseases. Over the past two to three years, there has been a rapid progress in our understanding of the differentiation programme of T(H)17 cells. Here, I summarize our current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of T(H)17 cells, and provide my personal perspectives on the future studies that are required to elucidate this lineage in more detail.

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TH17 and Treg cells share a common requirement for TGF-β in their differentiation despite expressing distinct transcriptional regulators (RORγt vs. Foxp3) and demonstrating opposing functions.
“TH17 and Treg cells share a common requirement for TGF-p in their differentiation requirements despite expressing distinct transcriptional regulators (RORγt vs. Foxp3 respectively) and demonstrating opposing functions (inflammatory vs. anti-inflammatory)(Bettelli et al., 2006; Dong, 2008; Littman and Rudensky, 2010; Mangan et al., 2006; O'Quinn et al., 2008; Veldhoen et al., 2006).”
From Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 (2011) · cites this paper as Dong, 2008

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692 · see citing works
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works
Self-citation
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371 · see citing works
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330 · see citing works
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,910 · see citing works
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848 · see citing works
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · see citing works
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works
Self-citation
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536 · see citing works
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520 · see citing works
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
TH-17 cells in the circle of immunity and autoimmunity
Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007) · Nature Immunology · doi:10.1038/ni0407-345 · Cited by 1,503 · see citing works
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,494 · see citing works
Self-citation
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
Self-citation
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel‐Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,442 · see citing works
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,367 · see citing works
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,362 · see citing works
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,174 · see citing works
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
Aujla, S. J., Chan, Y. R., Zheng, M., Fei, M., Askew, D. J., Pociask, D. A., Reinhart, T. A., McAllister, F. M., Edeal, J., Gaus, K., et al. (2008) · Nature Medicine · doi:10.1038/nm1710 · Cited by 1,162 · see citing works
Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053 · see citing works
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
Afkarian, M., Šedý, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L., & MURPHY, K. M. M. (2002) · Nature Immunology · doi:10.1038/ni794 · Cited by 1,038 · see citing works
IL-23 promotes tumour incidence and growth
Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature · doi:10.1038/nature04808 · Cited by 1,018 · see citing works
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (1995) · Immunity · doi:10.1016/1074-7613(95)90070-5 · Cited by 995 · see citing works
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955 · see citing works
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071397 · Cited by 937 · see citing works
Interleukin-17 family and IL-17 receptors
Moseley, T. A., Haudenschild, D. R., Rose, L., & Reddi, A. H. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00002-9 · Cited by 917 · see citing works
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
Hunter, C. A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1648 · Cited by 847 · see citing works
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 815 · see citing works
T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation
Li, M. O., Wan, Y. Y., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.014 · Cited by 728 · see citing works
T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells
Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.68 · Cited by 722 · see citing works
Interleukin 17–producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
Hsu, H., Yang, P., Wang, J., Wu, Q., Myers, R. C., Chen, J., Yi, J. S., Guentert, T., Tousson, A., Stanus, A. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1552 · Cited by 717 · see citing works
Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity
Spolski, R. J., & Leonard, W. J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090316 · Cited by 695 · see citing works
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T. W., Kamradt, T., & Lohoff, M. D. (2007) · Nature Immunology · doi:10.1038/ni1500 · Cited by 691 · see citing works
Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology
Uhlig, H. H., McKenzie, B. S., Hüe, S., Thompson, C., Joyce-Shaikh, B., Štëpánková, R., Robinson, N., Buonocore, S. M., Tlaskalová‐Hogenová, H., Cua, D. J., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.017 · Cited by 681 · see citing works
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works
IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner
Wei, L., Laurence, A. D. J., Elias, K. M., & O’Shea, J. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705100200 · Cited by 641 · see citing works
Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation
Zenewicz, L. A., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Karow, M. L., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.023 · Cited by 628 · see citing works
Lineage commitment in the immune system: the T helper lymphocyte grows upPreprint
Glimcher, L. H., & MURPHY, K. M. M. (2000) · Genes & Development · doi:10.1101/gad.14.14.1693 · Cited by 624 · see citing works
Follicular B helper T cells in antibody responses and autoimmunity
Vinuesa, C. G., Tangye, S. G., Moser, B., & Mackay, C. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1714 · Cited by 624 · see citing works
New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25
Hurst, S. D., Muchamuel, T., Gorman, D. M., Gilbert, J. M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T. T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.443 · Cited by 619 · see citing works
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
Michel, M., Keller, A. C., Paget, C., Fujio, M., Trottein, F., Savage, P. B., Wong, C., Schneider, E., Dy, M., & Leite‐de‐Moraes, M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061551 · Cited by 618 · see citing works
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
Qian, Y., Liu, C., Hartupee, J., Altuntas, C. Z., Gulen, M. F., Jane-wit, D., Xiao, J., Lu, Y., Giltiay, N., Liu, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1439 · Cited by 614 · see citing works
Microbial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586 · see citing works
Expanding the effector CD4 T-cell repertoire: the Th17 lineage
Harrington, L. E., Mangan, P. R., & Weaver, C. T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.017 · Cited by 585 · see citing works
Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity
Harris, T. J., Grosso, J. F., Yen, H., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4313 · Cited by 585 · see citing works
Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex
Toy, D., Kugler, D., Wolfson, M., Bos, T. V., Gurgel, J., Derry, J., Tocker, J., & Peschon, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.36 · Cited by 570 · see citing works
Interleukin-17 is a negative regulator of established allergic asthma
Schnyder‐Candrian, S., Togbe, D., Couillin, I., Mercier, I., Brombacher, F., Quesniaux, V. F. J., Fossiez, F., Ryffel, B., & Schnyder, B. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061401 · Cited by 564 · see citing works
Interleukin 25 promotes the initiation of proallergic type 2 responses
Angkasekwinai, P., Park, H., Wang, Y., Wang, Y., Chang, S. H., Corry, D. B., Liu, Y.-J., Zhu, Z., & Dong, C. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061675 · Cited by 553 · see citing works
Self-citation
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Mathur, A. N., Chang, H., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O’Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S., & Kaplan, M. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4901 · Cited by 548 · see citing works
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495 · see citing works
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Dong, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1807 · Cited by 487 · see citing works
Self-citation
Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production
Shibata, K., Yamada, H., Hara, H., Kishihara, K., & Yoshikai, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4466 · Cited by 481 · see citing works
Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection
Happel, K. I., Zheng, M., Young, E. A., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 448 · see citing works
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
Elias, K. M., Laurence, A. D. J., Davidson, T. S., Stephens, G. L., Kanno, Y., Shevach, E. M., & O’Shea, J. J. (2007) · Blood · doi:10.1182/blood-2007-06-096438 · Cited by 448 · see citing works
IL-25 regulates Th17 function in autoimmune inflammation
Kleinschek, M. A., Owyang, A. M., Joyce-Shaikh, B., Langrish, C. L., Chen, Y., Gorman, D. M., Blumenschein, W. M., McClanahan, T., Brombacher, F., Hurst, S. D., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061738 · Cited by 396 · see citing works
Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB
Shalom‐Barak, T., Quach, J., & Lotz, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27467 · Cited by 385 · see citing works
Functional Cooperation between Interleukin-17 and Tumor Necrosis Factor-α Is Mediated by CCAAT/Enhancer-binding Protein Family Members
Ruddy, M. J., Wong, G. C., Liu, X. K., Yamamoto, H., Kasayama, S., Kirkwood, K. L., & Gaffen, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308809200 · Cited by 364 · see citing works
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
Chang, S. H., Park, H., & Dong, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600256200 · Cited by 356 · see citing works
Self-citation
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
Kimura, A., Naka, T., & Kishimoto, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705268104 · Cited by 355 · see citing works
Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F
Kuestner, R. E., Taft, D. W., Haran, A. C., Brandt, C. S., Brender, T., Lum, K. D., Harder, B., Okada, S. L., Ostrander, C. D., Kreindler, J. L., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5462 · Cited by 349 · see citing works
Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
Schwandner, R., Yamaguchi, K., & Cao, Z. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1233 · Cited by 349 · see citing works
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression
Rengarajan, J., Mowen, K. A., McBride, K. D., Smith, E. D., Singh, H., & Glimcher, L. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011128 · Cited by 332 · see citing works
IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis
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T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics
Lee, G. R., Kim, S. T., Spilianakis, C. G., Fields, P. E., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.007 · Cited by 320 · see citing works
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700499200 · Cited by 319 · see citing works
Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells
Kang, S. G., Lim, H. W., ANDRISANI, O. M., Broxmeyer, H. E., & Kim, C. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3724 · Cited by 312 · see citing works
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works
Self-citation
Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells
Kurata, H., Lee, H. J., O’Garra, A., & Arai, N. (1999) · Immunity · doi:10.1016/s1074-7613(00)80142-9 · Cited by 299 · see citing works
IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression
Herber, D., Brown, T. P., Liang, S. C., Young, D. A., Collins, M. A., & Dunussi‐Joannopoulos, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3822 · Cited by 297 · see citing works
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
Chang, S. H., & Dong, C. (2007) · Cell Research · doi:10.1038/cr.2007.35 · Cited by 280 · see citing works
Self-citation
Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Young, D. A., Hegen, M., Margery, H. L., Whitters, M. J., Albert, L. M., Lowe, L. D., Senices, M., Wu, P. W., Sibley, B. J., Leathurby, Y., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22452 · Cited by 275 · see citing works
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state
Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm045 · Cited by 268 · see citing works
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
Lohoff, M. D., Mittrücker, H., Prechtl, S., Bischof, S., Sommer, F. O., Kock, S., Ferrick, D. A., Duncan, G. S., Gessner, A., & Mak, T. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182425099 · Cited by 253 · see citing works
Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin‐17 receptor IgG1 Fc fusion protein
Bush, K., Farmer, K. M., Walker, J. S., & Kirkham, B. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10173 · Cited by 251 · see citing works
T‐cell tolerance or function is determined by combinatorial costimulatory signals
Nurieva, R., Thomas, S., Nguyen, T. D., Martín‐Orozco, N., Wang, Y., Murali‐Krishna, K., Yu, X., & Dong, C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601146 · Cited by 245 · see citing works
Self-citation
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
Chung, Y., Yang, X. O., Chang, S. H., Ma, L., Tian, Q., & Dong, C. (2006) · Cell Research · doi:10.1038/sj.cr.7310106 · Cited by 232 · see citing works
Self-citation
Th1 and Th2 cells
Dong, C., & Flavell, R. A. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200101000-00009 · Cited by 216 · see citing works
Self-citation
Ets-1 is a negative regulator of Th17 differentiation
Moisan, J., Grenningloh, R., Bettelli, E., Oukka, M., & Ho, I. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070994 · Cited by 204 · see citing works
Activation of retinoic acid receptor‐α favours regulatory T cell induction at the expense of IL‐17‐secreting T helper cell differentiation
Schambach, F., Schupp, M., Lazar, M. A., & Reiner, S. L. (2007) · European Journal of Immunology · doi:10.1002/eji.200737621 · Cited by 198 · see citing works
The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches
Eberl, G., & Littman, D. R. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00074.x · Cited by 192 · see citing works
Identification of a Novel Cytokine, ML-1, and Its Expression in Subjects with Asthma
Kawaguchi, M., Onuchic², L. F., Li, X., Essayan, D. M., Schroeder, J. T., Xiao, H.-Q., Liu, M. C., Krishnaswamy, G. A., Germino, G. G., & Huang, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4430 · Cited by 189 · see citing works
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis
Thakker, P., Leach, M. W., Kuang, W., Benoit, S., Leonard, J. P., & Marušić, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2589 · Cited by 178 · see citing works
CCR6 and CCL20
Williams, I. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.036 · Cited by 167 · see citing works
Emerging possibilities in the development and function of regulatory T cells
Wing, K., Fehervari, Z. T., & Sakaguchi, S. (2006) · International Immunology · doi:10.1093/intimm/dxl044 · Cited by 154 · see citing works
Interleukin-17F Induces Pulmonary Neutrophilia and Amplifies Antigen-induced Allergic Response
Oda, N., Canelos, P., Essayan, D. M., Plunkett, B. A., Myers, A. C., & Huang, S.-K. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-778oc · Cited by 145 · see citing works
EXPRESSION OF IL-17 IN HUMAN MEMORY CD45RO+T LYMPHOCYTES AND ITS REGULATION BY PROTEIN KINASE A PATHWAY
Shin, H. C. K., Benbernou, N., Esnault, S. J., & Guenounou, M. (1999) · Cytokine · doi:10.1006/cyto.1998.0433 · Cited by 143 · see citing works
Role of interleukin‐17F in chronic inflammatory and allergic lung disease
Hizawa, N., Kawaguchi, M., Huang, S., & Nishimura, M. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02550.x · Cited by 118 · see citing works
Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4
Hu, C.-M., Jang, S. Y., Fanzo, J., & Pernis, A. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205895200 · Cited by 112 · see citing works
IL-21–induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses
Harada, M., Magara-Koyanagi, K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20062206 · Cited by 112 · see citing works
Oral Tolerance and TGF-β -Producing Cells
Faria, A. M. C., & Weiner, H. L. (2006) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152806778256034 · Cited by 107 · see citing works
Regulation of immune and autoimmune responses by ICOS
Dong, C., & Nurieva, R. (2003) · Journal of Autoimmunity · doi:10.1016/s0896-8411(03)00119-7 · Cited by 93 · see citing works
Self-citation
The Induction of EAE Is Only Partially Dependent on TNF Receptor Signaling but Requires the IL-1 Type I Receptor
Schiffenbauer, J., Streit, W. J., Butfiloski, E. J., Labow, M., Edwards, C. K., & Moldawer, L. L. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4851 · Cited by 84 · see citing works
Recent Advances in the Mechanisms of Action and Physiological Functions of the Retinoid-Related Orphan Receptors (RORs)
Jetten, A. M. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010042634497 · Cited by 74 · see citing works
Selective Requirement of p38α MAPK in Cytokine-Dependent, but Not Antigen Receptor-Dependent, Th1 Responses
Berenson, L. S., Yang, J., Sleckman, B. P., Murphy, T. L., & MURPHY, K. M. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4616 · Cited by 52 · see citing works
Interleukin-12/23 Monoclonal Antibody for Psoriasis
Okamoto, H., & Momohara, S. (2007) · New England Journal of Medicine · doi:10.1056/nejmc070648 · Cited by 4 · see citing works

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NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works
CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,340 · see citing works
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205 · see citing works
Self-citation
Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
Chung, Y., Chang, S. H., Martínez, G., Yang, X. O., Nurieva, R., Kang, H. S., Ma, L., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.007 · Cited by 1,198 · see citing works
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Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells
Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T.-Y., Watford, W. T., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.009 · Cited by 1,152 · see citing works
Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs
Yang, X. O., Nurieva, R., Martínez, G., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.007 · Cited by 1,129 · see citing works
Self-citation
Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) · Science · doi:10.1126/science.1232227 · Cited by 1,070 · see citing works
γδ T cell effector functions: a blend of innate programming and acquired plasticity
Bonneville, M., O'Brien, R. L., & Born, W. K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2781 · Cited by 952 · see citing works
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
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Dendritic-Cell-Based Therapeutic Cancer Vaccines
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MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
Du, C., Liu, C., Kang, J., Zhao, G., Ye, Z., Huang, S., Li, Z., Wu, Z., & Pei, G. (2009) · Nature Immunology · doi:10.1038/ni.1798 · Cited by 711 · see citing works
T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity
Martín‐Orozco, N., Muranski, P. J., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.014 · Cited by 797 · see citing works
Self-citation
Analysing biological pathways in genome-wide association studies
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2884 · Cited by 757 · see citing works
The noncanonical NF‐κB pathway
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Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints
Garlet, G. P. (2010) · Journal of Dental Research · doi:10.1177/0022034510376402 · Cited by 724 · see citing works
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
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Epigenetic control of T-helper-cell differentiation
Wilson, C. B., Rowell, E. A., & Sekimata, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2487 · Cited by 678 · see citing works
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism
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Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
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NF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis -induced colon tumorigenesis
Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612 · see citing works
Cytokine Regulation and Function in T Cells
Dong, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053702 · Cited by 594 · see citing works
Self-citation
Orchestrating the orchestrators: chemokines in control of T cell traffic
Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 592 · see citing works
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
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Immunopathology of inflammatory bowel disease
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Recent Advances on the Role of Cytokines in Atherosclerosis
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The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
Sawa, S., Lochner, M., Satoh‐Takayama, N., Dulauroy, S., Berard, M., Kleinschek, M. A., Cua, D., Santo, J. P. D., & Eberl, G. (2011) · Nature Immunology · doi:10.1038/ni.2002 · Cited by 568 · see citing works
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Luci, C., Reynders, A., Ivanov, I. I., Cognet, C., Chiche, L., Chasson, L., Hardwigsen, J., Anguiano, E., Banchereau, J., Chaussabel, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1681 · Cited by 551 · see citing works
When worlds collide: Th17 and Treg cells in cancer and autoimmunity
Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535 · see citing works
Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
Zhang, J., Yan, J., Xu, J., Pang, X.-H., Chen, M.-S., Li, L., Wu, C. Y., Li, S., & Zheng, L. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.033 · Cited by 535 · see citing works
IL-17 cytokines in immunity and inflammation
Jin, W., & Dong, C. (2013) · Emerging Microbes & Infections · doi:10.1038/emi.2013.58 · Cited by 528 · see citing works
Self-citation
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.010 · Cited by 528 · see citing works
The roles of IL‐17A in inflammatory immune responses and host defense against pathogens
Iwakura, Y., Nakae, S., Saijo, S., & Ishigame, H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00699.x · Cited by 517 · see citing works
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
DeNardo, D. G., Andreu, P., & Coussens, L. M. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9223-6 · Cited by 513 · see citing works
Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens
Curtis, M. M., & Way, S. S. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.03017.x · Cited by 501 · see citing works
IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
Li, L., Huang, L., Vergis, A. L., Ye, H., Bajwa, A., Narayan, V., Strieter, R. M., Rosin, D. L., & Okusa, M. D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38702 · Cited by 485 · see citing works
Host response mechanisms in periodontal diseases
Silva, N., Abusleme, L., Bravo, D., Dutzan, N., García-Sesnich, J., Vernal, R., Hernández, M., & Gamonal, J. A. (2015) · Journal of Applied Oral Science · doi:10.1590/1678-775720140259 · Cited by 482 · see citing works
Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
de Beaucoudrey, L., Puel, A., Filipe‐Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J. M., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 438 · see citing works
Th17 and Th1 T-Cell Responses in Giant Cell Arteritis
Deng, J., Younge, B. R., Olshen, R. A., Goronzy, J. J., & Weyand, C. M. (2010) · Circulation · doi:10.1161/circulationaha.109.872903 · Cited by 435 · see citing works
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
Ho, I., Tai, T.-S., & Pai, S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2476 · Cited by 425 · see citing works
Halofuginone Inhibits T H 17 Cell Differentiation by Activating the Amino Acid Starvation Response
Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., et al. (2009) · Science · doi:10.1126/science.1172638 · Cited by 422 · see citing works
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
Guo, L., Wei, G., Zhu, J., Liao, W., Leonard, W. J., Zhao, K., & Paul, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906988106 · Cited by 410 · see citing works
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis
Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Pérez, N., Yasukawa, H., Snick, J. V., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090545 · Cited by 409 · see citing works
Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management
Yazdanbakhsh, K., Ware, R. E., & Pirenne, F. (2012) · Blood · doi:10.1182/blood-2011-11-327361 · Cited by 406 · see citing works
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesisPreprint
Wei, H., Wei, S., Gan, B., Xu, P., Zou, W., & Guan, J. (2011) · Genes & Development · doi:10.1101/gad.2051011 · Cited by 402 · see citing works
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature · doi:10.1038/nature23475 · Cited by 395 · see citing works
Self-citation
IL-33–activated dendritic cells induce an atypical TH2-type response
Rank, M. A., Kobayashi, T., Kozaki, H., Bartemes, K. R., Squillace, D. L., & Kita, H. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.026 · Cited by 395 · see citing works
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394 · see citing works
Revisiting Human IL-12Rβ1 Deficiency
de Beaucoudrey, L., Samarina, A., Bustamante, J. C., Cobat, A., Boisson‐Dupuis, S., Feinberg, J. M., Al‐Muhsen, S., Jannière, L., Rose, Y., de Suremain, M., et al. (2010) · Medicine · doi:10.1097/md.0b013e3181fdd832 · Cited by 394 · see citing works
Cellular and molecular basis for the regulation of inflammation by TGF-
Yoshimura, A., Wakabayashi, Y., & Mori, T. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq043 · Cited by 394 · see citing works
The plasticity of human Treg and Th17 cells and its role in autoimmunity
Kleinewietfeld, M., & Hafler, D. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.009 · Cited by 389 · see citing works
CD4 T Helper Cell Subsets and Related Human Immunological Disorders
Zhu, X., & Zhu, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218011 · Cited by 380 · see citing works
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 377 · see citing works
Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364 · see citing works
IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma
Liu, J., Duan, Y., Cheng, X., Chen, X., Xie, W., Long, H., Lin, Z., & Zhu, B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.021 · Cited by 360 · see citing works
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
Martín‐Orozco, N., Chung, Y., Chang, S. H., Wang, Y., & Dong, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200838475 · Cited by 359 · see citing works
Self-citation
SUMO: From Bench to Bedside
Chang, H., & Yeh, E. T. H. (2020) · Physiological Reviews · doi:10.1152/physrev.00025.2019 · Cited by 355 · see citing works
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
Kudva, A., Scheller, E. V., Robinson, K. M., Crowe, C. R., Choi, S. M., Slight, S. R., Khader, S. A., Dubin, P. J., Enelow, R. I., Kolls, J. K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002194 · Cited by 346 · see citing works
Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12
Ma, C. S., Suryani, S., Avery, D. T., Chan, A., Nanan, R. K. H., Santner‐Nanan, B., Deenick, E. K., & Tangye, S. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.64 · Cited by 345 · see citing works
Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin‐17A production
van Hamburg, J. P., Asmawidjaja, P. S., Davelaar, N., Mus, A. M. C., Colin, E. M., Hazes, J. M. W., Dolhain, R. J. E. M., & Lubberts, E. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30093 · Cited by 338 · see citing works
Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome
Chandesris, M., Melki, I., Natividad, A., Puel, A., Fieschi, C., Ling, Y., Thumerelle, C., Oksenhendler, É., Boutboul, D., Thomas, C., et al. (2012) · Medicine · doi:10.1097/md.0b013e31825f95b9 · Cited by 338 · see citing works
Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy
Baldeviano, G. C., Barin, J. G., Talor, M. V., Srinivasan, S., Bedja, D., Zheng, D., Gabrielson, K., Iwakura, Y., Rose, N. R., & Cihakova, D. (2010) · Circulation Research · doi:10.1161/circresaha.109.213157 · Cited by 334 · see citing works
Th17 Cells in Cancer: The Ultimate Identity Crisis
Bailey, S. R., Nelson, M. H., Himes, R. A., Li, Z., Mehrotra, S., & Paulos, C. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00276 · Cited by 334 · see citing works
Inflammasome-independent regulation of IL-1-family cytokines
Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112306 · Cited by 326 · see citing works
Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis
Tyagi, A. M., Srivastava, K., Mansoori, M. N., Trivedi, R., Chattopadhyay, N., & Singh, D. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044552 · Cited by 325 · see citing works
Regulation of nuclear factor-κB in autoimmunity
Sun, S., Chang, J., & Jin, J. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.01.004 · Cited by 324 · see citing works
Tumor microenvironments direct the recruitment and expansion of human Th17 cells
Su, X., Ye, J., Hsueh, E. C., Zhang, Y., Hoft, D. F., & Peng, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902813 · Cited by 324 · see citing works
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
Woellner, C., Gertz, E. M., Schäffer, A. A., Lagos, M., Perro, M., Glocker, E., Pietrogrande, M. C., Cossu, F., Franco, J. L., Matamoros, N., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.059 · Cited by 313 · see citing works
Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives
Tafalla, C., Bøgwald, J., & Dalmo, R. A. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.02.029 · Cited by 313 · see citing works
Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
Jiang, R., Tan, Z., Deng, L., Chen, Y., Xia, Y., Gao, Y., Wang, X., & Sun, B. (2011) · Hepatology · doi:10.1002/hep.24486 · Cited by 310 · see citing works
Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses
Nizri‏, E., Irony-Tur-Sinai, M., Lory, O., Orr‐Urtreger, A., Lavi, E., & Brenner, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902212 · Cited by 308 · see citing works
Cytokine responses against periodontal infection: protective and destructive roles
Liu, Y.-C. G., Lerner, U. H., & Teng, Y.-T. A. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00321.x · Cited by 304 · see citing works
Early signaling events that underlie fate decisions of naive CD 4+ T cells toward distinct T‐helper cell subsets
Yamane, H., & Paul, W. E. (2013) · Immunological Reviews · doi:10.1111/imr.12032 · Cited by 304 · see citing works
Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of Neutrophils
Zhang, X., Majlessi, L., Dériaud, E., Leclerc, C., & Lo‐Man, R. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.016 · Cited by 302 · see citing works
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah, K., Lee, W., Lee, S., Kim, S., Kang, S. W., Craft, J. E., & Kang, I. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2964 · Cited by 298 · see citing works
Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
Manicassamy, S., Ravindran, R., Deng, J., Oluoch, H., Denning, T. L., Kasturi, S. P., Rosenthal, K. M., Evavold, B. D., & Pulendran, B. (2009) · Nature Medicine · doi:10.1038/nm.1925 · Cited by 298 · see citing works
Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease
Reynolds, J. M., Pappu, B. P., Peng, J., Martínez, G., Zhang, Y., Chung, Y., Ma, L., Yang, X. O., Nurieva, R., Tian, Q., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.010 · Cited by 295 · see citing works
Self-citation
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
Damasceno, L. E. A., Prado, D. D. S., Veras, F. P., Fonseca, M. M., Toller-Kawahisa, J. E., Rosa, M. H., Públio, G. A., Martins, T. V., Ramalho, F. S., Waisman, A., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190613 · Cited by 289 · see citing works
TGF-β Regulation of T Cells
Chen, W. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-045939 · Cited by 288 · see citing works
Pathogenesis beyond the cancer clone(s) in multiple myeloma
Bianchi, G., & Munshi, N. C. (2015) · Blood · doi:10.1182/blood-2014-11-568881 · Cited by 285 · see citing works
Role of regulatory T cells in psoriasis pathogenesis and treatment
Nußbaum, L., Chen, Y. L., & Ogg, G. S. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19380 · Cited by 283 · see citing works
Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease
Crome, S. Q., Wang, A. Y., & Levings, M. K. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04037.x · Cited by 276 · see citing works
DC activated via dectin‐1 convert Treg into IL‐17 producers
Osorio, F., LeibundGut‐Landmann, S., Lochner, M., Lahl, K., Sparwasser, T. D., Eberl, G., & Sousa, C. R. E. (2008) · European Journal of Immunology · doi:10.1002/eji.200838950 · Cited by 273 · see citing works
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Okamoto, K., Iwai, Y., Oh‐hora, M., Yamamoto, M., Morio, T., Aoki, K., Ohya, K., Jetten, A. M., Akira, S., Muta, T., et al. (2010) · Nature · doi:10.1038/nature08922 · Cited by 268 · see citing works
IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani
Pitta, M. G. D. R., Romano, A., Cabantous, S., Henri, S., Hammad, A., Kouriba, B., Argiro, L., el Kheir, M., Bucheton, B., Mary, C., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38813 · Cited by 266 · see citing works
Activated Monocytes in Peritumoral Stroma of Hepatocellular Carcinoma Promote Expansion of Memory T Helper 17 Cells
Kuang, D., Peng, C., Zhao, Q., Wu, Y., Chen, M.-S., & Zheng, L. (2009) · Hepatology · doi:10.1002/hep.23291 · Cited by 264 · see citing works
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414189111 · Cited by 262 · see citing works
Acute graft-versus-host disease: from the bench to the bedside
Socié, G., & Blazar, B. R. (2009) · Blood · doi:10.1182/blood-2009-06-204669 · Cited by 262 · see citing works
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
Curti, A., Trabanelli, S., Salvestrini, V., Baccarani, M., & Lemoli, R. M. (2008) · Blood · doi:10.1182/blood-2008-07-144485 · Cited by 259 · see citing works
The prevalence of Th17 cells in patients with gastric cancer
Zhang, B., Rong, G., Wei, H., Zhang, M., Bi, J., Ma, L., Xue, X., Wei, G., Liu, X., & Fang, G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.060 · Cited by 257 · see citing works
Lymphocytes in cancer development: Polarization towards pro-tumor immunity
Ruffell, B., DeNardo, D. G., Affara, N. I., & Coussens, L. M. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.002 · Cited by 253 · see citing works
GATA3: a master of many trades in immune regulation
Wan, Y. Y. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.002 · Cited by 248 · see citing works
The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications
Zeng, C., Shi, X., Zhang, B., Liu, H., Zhang, L., Ding, W., & Zhao, Y. X. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0816-5 · Cited by 248 · see citing works
Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
Hou, W., Kang, H. S., & Kim, B. S. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082030 · Cited by 246 · see citing works
Th17 cytokines and their emerging roles in inflammation and autoimmunity
Fouser, L. A., Wright, J. F., Dunussi‐Joannopoulos, K., & Collins, M. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00712.x · Cited by 243 · see citing works
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
Minegishi, Y., Saitō, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082767 · Cited by 242 · see citing works
IL-17 family member cytokines: Regulation and function in innate immunity
Reynolds, J. M., Angkasekwinai, P., & Dong, C. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.002 · Cited by 237 · see citing works
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Authors: Dong, C.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Dong, Chen
ORCID: Dong, Chen
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-05
Volume: 8
Issue: 5
Pages: 337-348
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2295
OpenAlex: W2074067501
Cited by: 1,064
References: 118
Citations by year: 2026: 21 · 2025: 18 · 2024: 22 · 2023: 29 · 2022: 36 · 2021: 45 · 2020: 35 · 2019: 37 · 2018: 48 · 2017: 50 · 2016: 56 · 2015: 62 · 2014: 76 · 2013: 72 · 2012: 88
FWCI: 9.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: Th17 cells, T helper cell differentiation, CD4+ T cells, transcriptional regulation, cytokine signaling, gene expression, immune disorders
MeSH terms: Animals, Autoimmune Diseases, Cell Differentiation, Communicable Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Inflammation, Transcription Factors, Transcription, Genetic, Gene Expression, Cytokines, Cell Lineage, Interleukin-17

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TH17 cells in development: an updated view of their molecular identity and genetic programming

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