Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
den Braber, Ineke, Mugwagwa, Tendai, Vrisekoop, Nienke, Westera, Liset, Mögling, Ramona, Bregje de Boer, Anne, Willems, Neeltje, Schrijver, Elise H.R. +10 more·2012·Immunity
Cited by (573)
Items 401–500 of 573
- Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?Rachel Elizabeth Cooke, Rachel M. Koldej, David Ritchie · 2019 · Journal of Oncology
- A Single-Cell Perspective on Memory T-Cell DifferentiationLorenz Kretschmer, Dirk Hans Busch, Veit R. Buchholz · 2021 · Cold Spring Harbor Perspectives in Biology
- Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacementJodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates · 2025 · eLife
- Long-term consequences of Hodgkin lymphoma therapy on T-cell lymphopoiesisIsabelle Pellier, Gilles Rénier, Josué Rakotonjanahary, MARIE A. P. AUDRAIN, Elsa Berardi, Martine Gardembas, Aline Clavert, Marie Pierre Moles, Stéphanie Proust Houdemont, Yves Réguerre et al. · 2014 · Journal of Allergy and Clinical Immunology
- Differential Cytokine Utilization and Tissue Tropism Results in Distinct Repopulation Kinetics of Naïve vs. Memory T Cells in MiceHye Kyung Kim, Hyunsoo Chung, Juntae Kwon, Ehydel Castro, Christopher Johns, Nga Voong Hawk, SuJin Hwang, Jung‐Hyun Park, Ronald E. Gress · 2019 · Frontiers in Immunology
- The human T‐cell repertoire grows upJames J Moon, Marc K. Jenkins · 2015 · Immunology and Cell Biology
- Time isn’t kind to female T cellsCassandra Joan McGill, Bérénice Anath Benayoun · 2022 · Nature Aging
- Correlation of cell‐surface CD 8 levels with function, phenotype and transcriptome of naive CD 8 T cellsRenu Balyan, Rupali Gund, Amanpreet Singh Chawla, Satyajeet Khare, Saurabh J. Pradhan, Sanket Rane, Sanjeev Galande, Jeannine Marie Durdik, Anna George, Vineeta Bal et al. · 2018 · Immunology
- A mathematical study of CD8+ T cell responses calibrated with human dataJohn Paul Gosling, Sheeja M. Krishnan, Grant Lythe, Benny Chain, Cameron D. A. Mackay, Carmen Molina-Parı́s · 2018 · arXiv (Cornell University)
- How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributionsRenaud Dessalles, Maria Rita D'Orsogna, Tom Chou · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Delineating the short- and long-term impact of ionizing radiation on antigen-inexperienced CD8+ T cell subsetsMohammad Heidarian, Shravan Kumar Kannan, Whitney L. Swanson, Thomas S. Griffith, John T. Harty, Vladimir P. Badovinac · 2025 · JCI Insight
- Age-Related Thymic InvolutionMarvin Paulo Lins, Maria Danielma dos Santos Reis · 2025 · Advances in experimental medicine and biology
- 11-deoxycortisol positively correlates with T cell immune traits in physiological conditionsChunying Peng, Xun Jiang, Martin Jaeger, Pepijn van Houten, Antonius Eduard van Herwaarden, Valerie A. C. M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra et al. · 2023 · EBioMedicine
- Human T cell development and aging: Remodeling throughout the lifespanLipeng Mao, Qiuyue Feng, Oscar Junhong Luo, Guobing Chen, Xiao Sean Leng · 2024 · Aging Research
- How lymphocytes add upBecca Asquith, Rob J. de Boer · 2016 · Nature Immunology
- An evolutionarily conserved coronin-dependent pathway defines cell population sizeTohnyui Ndinyanka Fabrice, Christelle Bianda, Haiyan Zhang, Rajesh Jayachandran, Julie Ruer‐Laventie, Mayumi Mori, Despina Moshous, Geoffrey Fucile, Alexander Schmidt, Jean Pieters · 2022 · Science Signaling
- Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humansVeronica Locher, Sara Park, Daniel G. Bunis, Stephanie Makredes, Margareta Mayer, Trevor D. Burt, Gabriela K. Fragiadakis, Joanna Halkias · 2023 · JCI Insight
- The T Cells in an Ageing Virtual MouseMario Castro, Grant Lythe, Carmen Molina-Parı́s · 2017 · Springer eBooks
- AGE-DEPENDENT CHANGES OF T-REGULATORY AND Th17 SUBSET LEVELS IN PERIPHERAL BLOOD FROM HEALTHY HUMANSА. П. Топтыгина, Elena L. Semikina, С. В. Петричук, Закиров Рустам Шакирович, О. В. Курбатова, Копыльцова Елена Анатольевна, Yu. A. Komakh · 2017 · Medical Immunology (Russia)
- PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cellsJyh Liang Hor, Edward C. Schrom, Abigail Wong-Rolle, Luke F. Vistain, Wanjing Shang, Qiang Dong, Chen Ning Zhao, Chengcheng Jin, Ronald N. Germain · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Cellular gradient flow structure linking single-cell-level rules and population-level dynamicsHoriguchi, Shuhei A., Kobayashi, Tetsuya J. · 2023 · Physical Review Research
- OP0049 Aberrant vista expression on cd45ra+cd25dim th-cells in giant cell arteritisRebeca Hid Cadena, Rosanne D. Reitsema, Wayel Habib Abdulahad, Minke G. Huitema, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer · 2018 · Annals of the Rheumatic Diseases
- Coronin 1-dependent cell density sensing and regulation of the peripheral T cell population sizeTohnyui Ndinyanka Fabrice, Mayumi Mori, Jean Pieters · 2024 · Oxford Open Immunology
- The effect of plant-derived polyphenols on the immune system during aging: a systematic reviewBeatriz Santana Mendonça, Laura Maria Morales Nascimento, Jamylle Nunes de Souza‐Ferro, Maria Danielma dos Santos Reis · 2024 · Immunopharmacology and Immunotoxicology
- Cancer Uses the Common Morphogenesis Source of the HostAleksey N. Shoutko · 2020 · Open Journal of Biophysics
- Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cellsNoah A. Kaitz, Cindy Zuleger, Peng Yu, Michael A. Newton, Richard J. Albertini, Mark R. Albertini · 2022 · Mutation Research/Reviews in Mutation Research
- Model of age-dependent dynamics and biokinetics of T-cells as natural biodosimetersEvgenia I. Tolstykh, Alexandra V. Vozilova, А. V. Akleyev, Vladimir I. Zalyapin · 2024 · Radiation and Environmental Biophysics
- Agent-Based Modeling of Immune Response to Study the Effects of Regulatory T Cells in Type 1 DiabetesQian Xu, Mustafa Cagdas Ozturk, Ali Çınar · 2018 · Processes
- IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)Е. К. Олейник, Alexey Viktorovich Churov, Виктор Михайлович Олейник · 2018 · Medical Immunology (Russia)
- Differential Requirement of Beclin 1 for Regulating the Balance of Naïve and Activated CD4+ T CellsRui Xia, Min Yang, Xiaorui Fu, Wenwen Du, Xin Gao, Gang Li, Sarangarajan Ranganathan, Xueguang Zhang, Jingting Jiang, Binfeng Lu · 2020 · Frontiers in Cell and Developmental Biology
- Why are cell populations maintained via multiple compartments?Flavia Feliciangeli, Hanan Dreiwi, Martín López‐García, Mario Castro, Carmen Molina-Parı́s, Grant Lythe · 2022 · Journal of The Royal Society Interface
- The cellular immune system comes of ageRené A. W. van Lier, Taco Willem Kuijpers · 2017 · Journal of Allergy and Clinical Immunology
- Naïve T-cell decline is a significant contributor to expression changes in ageing bloodCameron Fraser, Brady M. Owen · 2024 · Frontiers in Aging
- Alemtuzumab Exposure and T Lymphocyte Depletion: A Population Pharmacokinetic‐Pharmacodynamic Model of Alemtuzumab Induction Therapy for Kidney TransplantationLukas K. van Vugt, Tom C. Zwart, Suzanne Bezstarosti, Sebastiaan Heidt, Marlies E. J. Reinders, Dennis Alexander Hesselink, Aiko P. J. de Vries, Brenda C. M. de Winter, Dirk Jan A. R. Moes · 2025 · Clinical Pharmacology & Therapeutics
- TREC dynamics as a biomarker of naive T-cell homeostasis in traumatic brain injury: a longitudinal analysisDarya A. Kashatnikova, Alesya S. Gracheva, Ekaterina V. Kalinina, Vladislav E. Zakharchenko, Tat'yana N. Krylova, Maryam B. Khadzhieva, Sergey S. Larin, Artem N. Kuzovlev, Lyubov E. Salnikova · 2026 · Frontiers in Medicine
- Memory T cell aging and rejuvenationSarah Adamo, Joel G. Rurik, Claire E. Gustafson, Marcus Buggert · 2026 · Immunity
- Purine salvage pathway protects CD8+ T cells from metabolic stressMasaki Tajima, He Hao, Baihao Zhang, Yuta Matsuoka, Kazuhiro Sonomura, Koshi Imami, Yosuke Isobe, Rae Maeda, Yu-Hsien Lin, Akihiro Shimba et al. · 2026 · Nature Immunology
- Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritisJ LI, Terukazu Sanui, Miyu Shida, Karen Yotsumoto, Mwannes Ahmad, Ziyu Wang, Meng Xiao, Chikako Hayashi, Takanori Shinjo, Takaharu Taketomi et al. · 2026 · Frontiers in Immunology
- OP0050 Gene polymorphisms of the glucocorticoid receptor and 11Β-hydroxysteroid dehydrogenase type 1 affect relevant clinical outcomes in anca associated vasculitisArno C. Hessels, Janneke Tuin, J.S.F. Sanders, Minke G. Huitema, Elisabeth F. C. van Rossum, F.J.W. Koper, André P. van Beek, Coen A. Stegeman, Abraham Rutgers · 2018 · Annals of the Rheumatic Diseases
- OP0051 Evolution of the vascular involvement objectified by pet/tac in patients with giant cell arteritis treated with tocilizumabDiana Prieto-Pena, Javier Loricera, J. L. Martín-Varillas, Monica Calderón-Goercke, Javier Narváez, Elena Aurrecoechea, I Villa, Santos Castañeda, Catalina Gómez‐Arango, Antonio Mera et al. · 2018 · Annals of the Rheumatic Diseases
- Concept of T-Cell Genus as a Basis for Analysis of the Results of Cytogenetic Studies after Local Bone Marrow ExposureEvgenia I. Tolstykh, Alexandra V. Vozilova, М. О. Дегтева, А. V. Akleyev · 2020 · Biology Bulletin
- Tipping the balance in CD4+ T cellsAmy S. Weinmann · 2023 · Nature Immunology
- Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and HumansS. Lee, Seung Geun Song, Doo Hyun Chung · 2023 · Immune Network
- Modeling the Dynamics of CD4+ T Cells in HIV-1 InfectionRuy Miguel Ribeiro · 2021 · Springer eBooks
- CD4 T Lymphopenia, Thymic Function, Homeostatic Proliferation and Late Complications Associated with Kidney TransplantationPhilippe Saas, Jamal Bamoulid, Cécile Courivaud, Jean-Michel Rebibou, Béatrice Gaugler, Didier Ducloux · 2013 · InTech eBooks
- Toward Quantifying the Thymic Dysfunctional State in Mouse Models of Inflammatory Bowel DiseaseAndreas Jansson, Anna-Karin Pernestig, Patric Nilsson, Mats Jirstrand, Elisabeth Hultgren Hörnquist · 2013 · Inflammatory Bowel Diseases
- p53 Keeps Bystanders at the GatesMichael Fray, Stephen C. Bunnell · 2014 · Immunity
- An evolutionary stability perspective on oncogenesis control in mature T-cell populationsHans H. Diebner, Jörg Kirberg, Ingo Roeder · 2015 · Journal of Theoretical Biology
- Premature Thymic Involution and Multiple SclerosisDavid G. Haegert · 2014 · Journal of Neurology & Neurophysiology
- Environmental Influences on the Immune System: The Aging Immune SystemJulia Nora Mälzer, Axel Ronald Schulz, Andreas Thiel · 2016 · Springer eBooks
- Mechanisms of Naive CD4+ T Cell Maintenance in the Elderly and Its Implications for AutoimmunityKornelis S. M. van der Geest, Elisabeth Brouwer, Wayel Habib Abdulahad, Annemieke M. H. Boots · 2017 · Springer eBooks
- Heterogeneity of lymphocytes as central operating units of the immune systemMilan Buc · 2019 · Vnitřní lékařství
- Potential role of mesenchymal stem cells in T cell agingXianmei Zhong, Jie Chen, Wen Bo, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Yueshui Zhao, Jing Shen et al. · 2023 · Journal of Molecular Medicine
- Age-Specific T Cell HomeostasisChristine Bourgeois, Delphine Sauce · 2018 · Springer eBooks
- A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang DistributionsGiulia Belluccini, Martín López‐García, Grant Lythe, Carmen Molina-Parı́s · 2021 · Research Square
- Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and replacement from precursorsJodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates · 2025 · eLife
- Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple SclerosisSandra Hellberg · 2019 · Linköping University medical dissertations
- Selection influences naive CD8+ TCR‐β repertoire sharingHao Yiu, Louis N. Schoettle, Marlene Garcia-Neurer, Joseph N. Blattman, Philip L. F. Johnson · 2020 · Immunology
- T-cell lymphopenia in frequent volunteer platelet donorsRichard Max Kaufman · 2023 · Hematology
- Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responsesYamato Sajiki, Satomi Ando, Charles M. Perkins, Yi-Chung Huang, Katie E. Smith, Carolyn M. Doerning, David A. Hildeman, Koichi Araki · 2026 · The Journal of Experimental Medicine
- HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and DiversityRui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai · 2025 · Advanced Science
- CD38 promotes LPS-induced innate-like activation and proliferation of CD8+ T lymphocytes in aged miceWendolaine Santiago‐Cruz, Enrique Espinosa, Jocelyn C. Pérez-Lara, Héctor Romero‐Ramírez, Priyadharshini Devarajan, Fabio García‐García, Juan Carlos Rodríguez‐Alba · 2025 · Frontiers in Aging
- When immunity multitasks: type 2 pathways power thymus regenerationGraham Anderson · 2026 · Immunology Letters
- T-Cell OntogenyCynthia Pelayo Mena, Yanet Ventura Enríquez, Claudia Mondragón-Albarrán, Adán Germán Gallardo-Rodríguez, Gabriel Aceves Castillo, Aldo Mujica Martínez, Moisés L. Mendoza Torres, Mónica Alethia Cureño-Díaz, Estibeyesbo Said Plascencia-Nieto, Erika Gómez Zamora et al. · 2026 · IntechOpen eBooks
- Immunosenescence as a driver of the transition from frailty to multimorbidityRuxia Qiu, Dong Zhang, Hui Feng · 2026 · Frontiers in Immunology
- Lymph node contraction links sex-biased naive CD8+ T cell decline to compromised antigen recognition during middle ageLutz Menzel, Maria Zschummel, Meghan J. O’Melia, Mårten Sandstedt, Hengbo Zhou, Pin-Ji Lei, Lingshan Liu, Hang Lee, Debattama R. Sen, Lance L. Munn et al. · 2026 · Nature Aging
- An Age-Structured Model for T Cell Homeostasis in VivoBedr’Eddine Aïnseba, Houssein H. Ayoub, Michel R. Langlais · 2014 · SIAM Journal on Applied Mathematics
- Interleukine 22Linus Williams, Rémy Bosselut · 2013 · médecine/sciences
- Mechanisms of Naive CD4+ T Cell Maintenance in the Elderly and Its Implications for AutoimmunityKornelis S. M. van der Geest, Elisabeth Brouwer, Wayel Habib Abdulahad, Annemieke M. H. Boots · 2019 · Springer eBooks
- HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyondYuepeng Zhang, Fabian Otte, Marcel P. Stoeckle, Alexander Thielen, Martin Däumer, Rolf Kaiser, Katharina Kusejko, Karin Jutta Metzner, Thomas Klimkait, and the Swiss HIV Cohort Study · 2024 · PLoS Pathogens
- T Cell Aging: An Important Target for Perioperative ImmunomodulationHaoning Lan, Shuyun Xu, Huili Li, Ruijuan Guo, Zhong Feng, Yun Wang · 2025 · Clinical Interventions in Aging
- The impact of model assumptions in interpreting cell kinetic studiesAda W. C. Yan, Ildar I. Sadreev, Jonas Mackerodt, Yan Zhang, Derek C. Macallan, Robert Busch, Becca Asquith · 2025 · PLoS Computational Biology
- Germinal center immune dynamics: challenges for effective vaccination in the elderlyCloé Brenna, Constantinos Petrovas · 2025 · Immunotherapy
- Variation in DNA enrichment among deuterium labeling studies is largely explained by different background correctionsErdem Şanal, José A. M. Borghans, Rob J. de Boer · 2025 · Journal of Immunological Methods
- Sex and the Aging Immune SystemDavid C. Gibson, Melanie Gubbels Bupp · 2018 · Elsevier eBooks
- Mechanistic Models of CD4 T Cell Homeostasis and Reconstitution in Health and DiseaseJoanna E. A. Lewis, Joseph Frank Standing · 2021 · Springer eBooks
- Sex-specific remodeling of T-cell compartment with aging: Implications for rat susceptibility to central nervous system autoimmune diseasesZorica Stojić-Vukanić, Ivan Pilipović, Nevena Arsenović-Ranin, Mirjana Dimitrijević, Gordana Leposavić · 2021 · Immunology Letters
- Age-Specific T Cell HomeostasisChristine Bourgeois, Delphine Sauce · 2019 · Springer eBooks
- Age, T Cell Homeostasis, and T Cell Diversity in HumansClaire E. Gustafson, David L. Lamar, Cornelia M. Weyand, Jörg J. Goronzy · 2019 · Springer eBooks
- Quelle valeur accorder a l'elevation du ratio lymphocytaire T CD4/CD8 dans le phenotypage lymphocytaire du sang : analyse d'une etude preliminaire et retrospective au CHU de BordeauxAlexandre Guy · 2015 · HAL
- The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4 + T cell responses of older adultsHuimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel Nadine Goronzy, Jun Jin, William James Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Abnormal CD8 T cells induce and track Alzheimer’s-like neurodegenerationChristopher J. Wheeler, Akanksha Panwar, Altan Rentsendorj, Michelle Jhun, Robert Cohen, Ryan Cordner, Nicole Gull, Robert N. Pechnick, Gretchen Duvall, Armen Mardiros et al. · 2021 · Research Square
- Multiple vaccine comparison in the same adults from the VITAL study reveals vaccine-specific and age-related humoral response patternsMarieke van der Heiden, Sudarshan Anand Shetty, Elske Bijvank, Lisa Beckers, Alper Çevirgel, Yannick van Sleen, Irina Tcherniaeva, Thierry Ollinger, Wivine Burny, Rob S. van Binnendijk et al. · 2024 · medRxiv
- Mathematical Modeling of Estrogen-Mediated Inflammation in the Gut and Immune SystemAriel M. Lighty, Mohammad Aminul Islam, Brenda Jane Smith, Ashlee N. Ford Versypt · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacementJodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates · 2025 · eLife
- Impact of Aging on T Cell Repertoire and ImmunityMarcia A. Blackman, David L. Woodland · 2013 · Springer eBooks
- Adaptive Immunity in Cardiovascular DiseaseDaniel Engelbertsen · 2013 · Lund University Publications (Lund University)
- Genetic Characterization of Pediatric T-cell Acute Lymphoblastic LeukemiaKristina Karrman · 2014 · Lund University Publications (Lund University)
- Ação de agonistas da via Wnt/beta-catenina em células T CD4+ murinasCarla C. C. dos Santos · 2015
- Perfil de expressão de genes da via Wnt/beta-catenina em timócitos e linfócitos T CD4+ de camundongos BALB/cTaccyanna Mikulski Ali · 2015
- Asthma and AgingNicola Alexander Hanania, Paula Jane Busse · 2015 · Springer eBooks
- Fractal and textural analysis of nuclear chromatin structural complexity in postnatal development and agingIgor V. Pantic · 2013
- Heterochronic Parabiosis Studies of the Aging Immune SystemJohn Davies · 2016 · UA Campus Repository (The University of Arizona)
- Immungerontologie – AlternsforschungBeatrix Grubeck-Loebenstein · 2015 · Zeitschrift für Rheumatologie
- Normalized Sequence Profiling Diversity Measured with Deep and Age-Related Decrease in TCR RepertoireDmitriy M. Chudakov, Aliona I. Bogdanova, Ilgar Z. Mamedov, Y. B. Lebedev, Dmitriy A. Bolotin, Sergey A. Lukyanov, M. Merzlyak, Maria A. Turchaninova, V. Britanova, Ekaterina V. Putintseva · 2014
- Thymic–Peripheral Crosstalk in Lymphodepletion TherapyMark E. Snyder, Donna L. Färber · 2017 · American Journal of Transplantation
- The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza InfectionLisa E. Wagar · 2013 · TSpace (University of Toronto)
- Study of T Cell Immunosenescence in Various Tissue CompartmentsMichelle Miron, Joseph J.C. Thome, Claire L. Gordon, Donna L. Färber · 2017 · Springer eBooks
- Proactive Maintenance of the Aging Feline Immune SystemShila K. Nordone · 2015 · Elsevier eBooks
- Immune Modulation and Its Role in AntiagingMustafa Erinç Sitar, Elçin Akduman Alaşehir, Belkız Öngen İpek · 2018 · Springer eBooks