Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans

den Braber, Ineke, Mugwagwa, Tendai, Vrisekoop, Nienke, Westera, Liset, Mögling, Ramona, Bregje de Boer, Anne, Willems, Neeltje, Schrijver, Elise H.R. +10 more·2012·Immunity
DOI 10.1016/j.immuni.2012.02.006

Cited by (573)

Items 501–573 of 573

  1. Age-Related Changes in the Murine Immune System
    Janko Nikolich‐Žugich, Nico A. Contreras, Christopher P. Coplen, Ilija D. Jeftic · 2019 · Springer eBooks
  2. The Exploration of an Effective Medical Countermeasure Enhancing Survival and Hematopoietic Recovery and Preventing Immune Insufficiency in Lethally-Irradiated Mice
    Tong Wu · 2020 · IUScholarWorks (Indiana University)
  3. Characteristics of the Immunoresponse in Elderly People and Autoimmunity
    O.V. Moskalets · 2020 · Advances in Gerontology
  4. Agent-Based Model of Heterogeneous T-Cell Activation in Vitro
    Shamik Majumdar, Carmen Molina-Parı́s, Dipankar Nandi, Grant Lythe · 2021 · Springer eBooks
  5. Modelling Naive T Cell Homeostasis
    Benedict P. Seddon, Sanket Rane, Andrew J. Yates · 2021 · Springer eBooks
  6. The Role of Antigen-Competitive Dynamics in Regulating the Immune Response
    Pantea Pooladvand, Peter Kim, Barbara Fazekas de St Groth · 2021 · Bulletin of Mathematical Biology
  7. Thymic and Peripheral T-cell Polarization in an Experimental Model of Russell’s Viper Venom-induced Acute Kidney Injury
    Sreyasi Das, Farhat Nasim, Roshnara Mishra, Raghwendra Mishra · 2021 · Immunological Investigations
  8. PROPORTION OF NAIVE CD45RA+ AND CD31+T-CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER STIMULATION WITH HOMEOSTATIC FACTORS IN VITRO
    Elena A. Blinova, Л. В. Гришина, A. E. Sizkov, Kozlov Va · 2021 · Medical Immunology (Russia)
  9. Ageing Mucosal Immunity and Its Consequences for Infectious Diseases in the Aged; A First Glance
    Marieke van der Heiden, Debbie van Baarle · 2021 · Healthy ageing and longevity
  10. The mandible's connected to the temporal bone, the temporal bone's connected to the....
    Jenkins Db · 1991 · PubMed
  11. Differential Maintenance, Function, and Transcriptional Profile of CD8⁺ T cells with Age
    Kristin R. Renkema · 2013 · UA Campus Repository (The University of Arizona)
  12. Age-Related Changes in the Murine Immune System
    Janko Nikolich‐Žugich, Nico A. Contreras, Christopher P. Coplen, Ilija D. Jeftic · 2021 · Springer eBooks
  13. Study of T Cell Immunosenescence in Various Tissue Compartments
    Michelle Miron, Joseph J.C. Thome, Claire L. Gordon, Donna L. Färber · 2019 · Springer eBooks
  14. T-Cell Homeostasis
    Julia Drylewicz, Kiki Tesselaar, José A. M. Borghans · 2018 · Springer eBooks
  15. Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
    JJC Thome, Boris Grinshpun, BV Kumar, Masaru Kubota, Yoshiaki Ohmura, Harvey Lerner, Gregory D. Sempowski, Y Shen, Donna L. Färber · 2018 · immuneACCESS
  16. Insights into the Subset, Antigen Specificity, and Localization of T Cells in Spatial Learning and Memory
    Ali Radjavi · 2014
  17. Age, T Cell Homeostasis, and T Cell Diversity in Humans
    Claire E. Gustafson, David L. Lamar, Cornelia M. Weyand, Jörg J. Goronzy · 2017 · Springer eBooks
  18. T-Cell Homeostasis
    Julia Drylewicz, Kiki Tesselaar, José A. M. Borghans · 2014 · Springer eBooks
  19. Maintaining naivety of T cells
    Ken R. Duffy · 2022 · eLife
  20. The immune system in 22q11.2 deletion syndrome
    Kathleen E. Sullivan · 2022 · Elsevier eBooks
  21. Recirculation of naive T lymphocytes
    Jandrić-Kočić Marijana C. · 2022 · Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma
  22. Chasing the chains by testing them twice
    Peter C. de Greef · 2023
  23. T Cell Development
    Sanjeev Kumar Sharma · 2023 · Springer eBooks
  24. Ink Trails
    Arpit Chandan Swain · 2023
  25. The T cell senescence in breast cancer
    Sikrit Denariyakoon · 2022
  26. CHANGES IN TELOMERE LENGTH IN LEUKOCYTES OF MALE RHESUS MACAQUES OF DIFFERENT AGES
    М.Ф. Тимина, Л.Е. Павлова, R M Kirgintsev, Агумава Аслан Анзорович · 2024 · Успехи геронтологии
  27. Increased ‘selfness’ in the tumor emerges as a possible immune sculpting mechanism: A pan-cancer data analysis of 32 solid tumors in TCGA
    Naren Chandran Sakthivel, G. V. Anoushka Chinmayi, Nagasuma R Chandra · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Coexistence of myasthenia gravis and lichen planus: A case report and systematic review of related case reports from 1971 to 2024
    Melika Jameie, Mobina Amanollahi, Bahareh Ahli, Ghasem Farahmand, Hana Magrouni, Payam Sarraf · 2024 · Clinical Case Reports
  29. Retrospective biodosimetry: Conversion of frequency of chromosomal translocations into organ doses
    Evgenia I. Tolstykh, Yu. R. Akhmadullina, Pavel A. Sharagin, Elena A. Shishkina, А. V. Akleyev · 2024 · Extreme Medicine
  30. Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement
    Jodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates · 2025 · eLife
  31. Tmem127-mediated immune receptor degradation regulates T cell homeostasis through the common gamma chain
    Marko Hasiuk, Arlinda Negraschus, Denis Seyres, Romina Marone, Gytis Jankevicius, Lena K. Siewert, Christoph Schultheiß, Aida Muñoz Blázquez, Mascha Binder, Anne‐Katrin Pröbstel et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling
    Jefferson Antônio Leite, Zeynep Ergün, Emmanouil Stylianakis, Rebecca Jasser, Florian Ingelfinger, Natalia Notarberardino Bos, Aysan Poursadegh Zonouzi, Michal Mark, Katlynn Carter, Xinyuan Liu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. 16,16 dimethyl-prostaglandin E2 Administration Prior to Lethal Irradiation Ameliorates Long-term Immune Suppression
    Tong Wu, Paul Artur Plett, Carol H. Sampson, Hui Lin Chua, Alexa Fisher, Hailin Feng, Jennifer Stashevsky, Louis M. Pelus, Christie M. Orschell · 2025 · Radiation Research
  34. Surrogate selection oversamples expanded T cell clonotypes
    Peng Yu, Yumin Lian, Elliot Xie, Cindy Zuleger, Richard J. Albertini, Mark R. Albertini, Michael A. Newton · 2025 · The Annals of Applied Statistics
  35. Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally
    Josephine Cecelia McGowan, Jed Katzenstein, Natalie S. Chace, Camila Wagner-Sanchez, Temi Okotore, Tolu Ogunfowora, Tallie Z. Baram, Oluwarotimi O. Folorunso, William A. Carlezon · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  36. ROLE OF SCAVENGER RECEPTOR CLASS B TYPE I IN THYMOPOIESIS
    Zhong Zheng · 2014 · UKnowledge (University of Kentucky)
  37. Additional file 1 of Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
    Mårten Sandstedt, Rosanna W. S. Chung, Camilla Skoglund, Anna K. Lundberg, Östgren, Carl Johan, Jan Ernerudh, Lena Jonasson · 2023 · Figshare
  38. Additional file 2 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
    Cheng Yang, Li, You, Yaqiu Hu, Qian Li, Lan, Yinghua, Yongguo Li · 2024 · Figshare
  39. Additional file 3 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
    Cheng Yang, Li, You, Yaqiu Hu, Li, Qian, Lan, Yinghua, Yongguo Li · 2024 · Figshare
  40. Additional file 1 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
    Cheng Yang, Li, You, Yaqiu Hu, Qian Li, Lan, Yinghua, Yongguo Li · 2024 · Figshare
  41. Additional file 4 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
    Cheng Yang, Li, You, Hu, Yaqiu, Qian Li, Lan, Yinghua, Yongguo Li · 2024 · Figshare
  42. Additional file 5 of Per-cell histone acetylation is associated with terminal differentiation in human T cells
    Cheng Yang, Li, You, Hu, Yaqiu, Qian Li, Lan, Yinghua, Yongguo Li · 2024 · Figshare
  43. Decoding thymic development: a single-cell atlas of tree shrew immunity
    Haibo Tang, Yunlin He, Lifeng Zhang, Yingying Cao, Baoying Li, Liang Liang, Chengxia Yun, Junyu Tao, Shanshan Zhai, Zhuxin Li et al. · 2026 · Frontiers in Immunology
  44. Is Thymic Involution Truly a Deterioration or an Adaptation?
    Yoh Iwasa, Rena Hayashi, Akane Hara, Kosei Matsuo · 2026 · Bulletin of Mathematical Biology
  45. Single-Cell Atlas of Fetal Immune Development Across Lung, Spleen, and Umbilical Cord Blood in Nonhuman Primates
    Ilhem Messaoudi, Brianna M. Doratt, Sheridan B. Wagner, Katelyn E. Keen, Uriel Avila, Oleg Varlamov · 2026 · Research Square
  46. Single‐Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota
    Chinna Susan Philip, Igor Filippov, Uku Haljasorg, Pärt Peterson · 2026 · European Journal of Immunology
  47. T cell proliferation in lymphopenia conditions : modeling, parameters estimation and mathematical analysis
    Houssein H. Ayoub · 2014
  48. Impact of chronic viral infection on the CD8 preimmune repertoire : when do we lose our naivety ?
    Cécile Alanio · 2015
  49. Rôle de la protéine Pleckstrin dans la génération de lymphocytes T CD8 mémoires et la mise en place d'une immunité tissulaire
    Mathilde Calvez · 2018 · theses.fr (ABES)
  50. Étude de la migration thymique : vers une reconstitution optimale du compartiment T
    Victoria Michaels Lopez · 2017 · theses.fr (ABES)
  51. Developmental architecture of human lymphopoiesis
    Kutaiba Alhaj Hussen · 2016
  52. Implication of the receptor for advanced glycation end-products (RAGE) during inflammation and ageing
    Thibault Teissier · 2019 · theses.fr (ABES)
  53. Targeting the metabolic environment to modulate T cell effector function
    Maria I. Matias · 2019 · theses.fr (ABES)
  54. Variations du développement thymique des lymphocytes T régulateurs : influence de l’âge et de la génétique
    Julie Darrigues · 2018
  55. Étude de la répartition asymétrique des molécules lytiques et métaboliques dans la division des lymphocytes T CD8+ humains
    Romain Jugelé · 2018
  56. Analyse protéomique et interactomique de l'activation des lymphocytes T humains primaires
    Philippe Nicolas · 2021
  57. Causes et conséquences de la variabilité interindividuelle des altérations lymphocytaires T dans la maladie rénale chronique
    Mathieu Legendre · 2021 · theses.fr (ABES)
  58. Impact of Epithelial to Mesenchymal Transition on the Regu-Lation of Anti-Tumor Immune Response in Breast Cancer
    Malina Xiao · 2021
  59. Le rôle des cytokines TNF-alpha et CCL2 dans l’atrophie et le dysfonctionnement thymique au cours de la leucémie aiguë myéloïde
    Meriem Ben Khoud · 2023
  60. Hybrid Systems Modeling of Donor T‐Cell Responses and Graft‐Versus‐Host‐Disease After Posttransplantation Cyclophosphamide Administration
    Hsuan‐Hao Fan, Jeannine S. McCune, Christopher George Kanakry, Donald E. Mager · 2026 · CPT Pharmacometrics & Systems Pharmacology
  61. Increased Selfness in the Tumor Emerges as a Possible Immune Sculpting Mechanism
    Naren Chandran Sakthivel, G. V. Anoushka Chinmayi, N Sri Chandra · 2026 · JCO Precision Oncology
  62. Anti-Aging the Immune System: Hype or Hope? A Mechanistic Review
    Ambreen Ilyas · 2026 · Premier Journal of Immunology
  63. Genetic Determinants of T-Cell Homeostasis in Critical Illness: An Exploratory Analysis of Immune Gene Variants and TREC Dynamics
    Alesya S. Gracheva, Darya A. Kashatnikova, Maryam B. Khadzhieva, Vladislav E. Zakharchenko, Tat'yana N. Krylova, Artem N. Kuzovlev, Lyubov E. Salnikova · 2026 · Journal of Personalized Medicine
  64. Rescuing age-associated vaccine hyporesponsiveness in murine and nonhuman primate models with an immunostimulatory vaccine adjuvant
    Jill Maxwell, Jason A. Joyner, James E. Norton, Walter Knapp, I‐Ming Wang, Gokul Swaminathan, Morgan A. Monslow, Michael P. Citron · 2026 · Human Vaccines & Immunotherapeutics
  65. ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution
    Pedro Ferreirinha, Pedro M. Rodrigues, Francisco Sobral, Bruno Cavadas, Rúben G. R. Pinheiro, Ana Mafalda Rocha, Yousuke Takahama, Martin Turner, Nuno L. Alves · 2026 · Cell Death and Differentiation
  66. Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire
    Isabella Sodi, Matthew V. Cowley, Trupti Gore, James Henderson, Andreas Tiffeau‐Mayer, Benny Chain · 2026 · Immunological Reviews
  67. Mechanisms and intervention strategies for thymic involution and T cell senescence
    Yan Liu, Xiao-na QIAO1, Huiyuan Zhang, Hong-Bo HU · 2026 · Shengming kexue
  68. Surgical Result for Patients Who Simultaneously Presented With Myasthenia Gravis and Thymoma
    Po-Chun Chang, Ping‐Chung Tsai, Ching‐Feng Wu, Yau‐Lin Tseng, En‐Kuei Tang, Tzu‐Ping Chen, Yi‐Ting Yen, Ching‐Yang Wu · 2026 · Thoracic Cancer
  69. TRECing down the source: naive and memory T cell generation in dirty mice and men
    Lyanne Y. Derksen, Elena de Dios Panal, Tamara M. J. Brouwers, Erdem Şanal, A.B.C. Schuren, Liset Westera, Sara P H van den Berg, Debbie van Baarle, Rob J. de Boer, Stephan P. Rosshart et al. · 2026 · The Journal of Immunology
  70. Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories
    Marina Terekhova, Maksim Kleverov, Thomas Francis, Dmitrii Usoltsev, Pavla Boháčová, Laura Arthur, Petr Tsurinov, Denis Kleverov, Luke Trinity, Kamila Husarcikova et al. · 2026 · Immunity
  71. Familial hypercholesterolaemia and thymic ageing in a Chinese cohort
    Fangyuan Li, Ju Zhang, Jialing Deng, Hang Zhang, Yu Hao, Jie Peng, Zengtao Wang, Lei Hua, Chenchen Wang, Jiajia Wang et al. · 2026 · European Heart Journal
  72. SA-β-Gal stratification reveals senescence-associated heterogeneity and differential cell death susceptibility in human CD8 effector T cells
    Luis Garza‐Martinez, Mark Apadeer, Nica Mariz Aquino, Paolo S. Turano, Elizabeth Akbulut, Dillon Oswald, Sukhwinder Singh, Patricia A. Fitzgerald-Bocarsly · 2026 · Frontiers in Immunology
  73. Radiation and Immunity in the Context of Cytomegalovirus and Aging
    Jason L. Pugh · 2013 · UA Campus Repository (The University of Arizona)