The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production
Open accessAbstract
Summary Invariant Natural Killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT cells, previously thought to be rare in huamns, were highly enriched in human and murine adipose tissue, and that as adipose tissue expands in obesity, iNKT cells were depleted, correlating with proinflammatory macrophage infiltration. iNKT cell numbers were restored in mice and humans after weight loss. Mice lacking iNKT cells had enhanced weight gain, larger adipocytes, fatty livers and insulin resistance on high fat diet. Adoptive transfer of iNKT cells into obese mice or in vivo activation of iNKT cells with their lipid ligand alpha-galactocylceramide decreased body fat, triglycerides, leptin, fatty liver, and improved insulin sensitivity through Th2 cell-type cytokine production by adipose-derived iNKT cells. This finding highlights the potential of iNKT cell-targeted therapies, previously proven to be safe in humans, in the management of obesity and its consequences.
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Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
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Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
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Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
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Immunology in the liver — from homeostasis to disease
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Metadata
- Authors
- Lynch, L., Nowak, M., Varghese, B., Clark, J., Hogan, A. E., Toxavidis, V., Balk, S. P., O’Shea, D., O’Farrelly, C., & Exley, M. A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 37
- Issue
- 3
- Pages
- 574-587
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2159081962
- Cited by
- 512
- References
- 55
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lynch, L., Nowak, M., Varghese, B., Clark, J., Hogan, A. E., Toxavidis, V., Balk, S. P., O’Shea, D., O’Farrelly, C., & Exley, M. A. (2012). Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production. Immunity. https://doi.org/10.1016/j.immuni.2012.06.016
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