Cited by 2,292Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

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Guilherme, Adilson, Virbasius, Joseph V., Puri, Vishwajeet, Czech, Michael P.·2008·Nature Reviews Molecular Cell Biology

Abstract

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.

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Crossref · 10.1038/nrm2391

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Authors
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Czech, Michael P.
Venue
Nature Reviews Molecular Cell Biology
Published
2008-05
Volume
9
Issue
5
Pages
367-377
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2012037560
Cited by
2,292
References
144
Citations by year
2026: 66 · 2025: 104 · 2024: 119 · 2023: 124 · 2022: 137 · 2021: 149 · 2020: 156 · 2019: 144 · 2018: 153 · 2017: 151 · 2016: 174 · 2015: 155 · 2014: 127 · 2013: 117 · 2012: 99
FWCI
11.29
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK030898, DK 32520, R37DK030898, DK030648, DK030898, P30DK032520, R01DK030648)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
adipocyte dysfunction, obesity, insulin resistance, type 2 diabetes, fatty acids, lipid droplets, lipid homeostasis, glucose homeostasis, skeletal muscle, insulin signaling, circulating fatty acids
MeSH terms
Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Lipolysis, Mitochondria, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Signal Transduction, Adipocytes, Muscle, Skeletal, PPAR gamma

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