The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity
Open accessAbstract
SUMMARY Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A coding polymorphism in the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is a susceptibility allele for human autoimmune and infectious disease. We report that Ptpn22 selectively regulated type 1 IFN production after TLR engagement in myeloid cells. Ptpn22 promoted host antiviral responses and was critical for TLR agonist-induced, type 1 IFN-dependent suppression of inflammation in colitis and arthritis. PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TRAF3 lysine 63-linked ubiquitination. The disease-associated PTPN22W variant failed to promote TRAF3 ubiquitination, type 1 IFN upregulation, and type 1 IFN-dependent suppression of arthritis. The findings establish a candidate innate immune mechanism of action for a human autoimmunity “risk” gene in the regulation of host defense and inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888
Stanford, S. M., Krishnamurthy, D., Falk, M. D., Messina, R., Debnath, B., Li, S., Liu, T., Kazemi, R., Dahl, R., He, Y., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101202j · Cited by 59
Self-citation
Cited by
Immunopathogenesis of Rheumatoid Arthritis
Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301
PTPN22: the archetypal non-HLA autoimmunity gene
Stanford, S. M., & Bottini, N. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.109 · Cited by 227
Self-citationLin, W. W., Yi, Z., Stunz, L. L., Maine, C. J., Sherman, L. A., & Bishop, G. A. (2015) · Science Signaling · doi:10.1126/scisignal.aaa5157 · Cited by 50
Metadata
- Authors
- Wang, Y., Shaked, I., Stanford, S. M., Zhou, W., Curtsinger, J. M., Mikulski, Z., Shaheen, Z. R., Cheng, G., Sawatzke, K., Campbell, A. M., Auger, J. L., Bilgic, H., Shoyama, F. M., Schmeling, D. O., Balfour, H. H., Hasegawa, K., Chan, A. C., Corbett, J. A., Binstadt, B. A., Mescher, M. F., Ley, K., Bottini, N., & Peterson, E. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 39
- Issue
- 1
- Pages
- 111-122
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2054355572
- Cited by
- 195
- References
- 2
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity. https://app.cochat.ai/papers/10.1016/j.immuni.2013.06.013
- The paper
- Wang, Y., Shaked, I., Stanford, S. M., Zhou, W., Curtsinger, J. M., Mikulski, Z., Shaheen, Z. R., Cheng, G., Sawatzke, K., Campbell, A. M., Auger, J. L., Bilgic, H., Shoyama, F. M., Schmeling, D. O., Balfour, H. H., Hasegawa, K., Chan, A. C., Corbett, J. A., Binstadt, B. A., . . . Peterson, E. J. (2013). The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity. Immunity. https://doi.org/10.1016/j.immuni.2013.06.013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
