Immunopathogenesis of Rheumatoid Arthritis

The Pathogenesis of Rheumatoid Arthritis

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Rheumatoid arthritis

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Evolving concepts of rheumatoid arthritis

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Cytokines in the pathogenesis of rheumatoid arthritis

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Genetics of rheumatoid arthritis contributes to biology and drug discovery

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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

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Secukinumab in plaque psoriasis—results of two phase 3 trials

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The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

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Targeting IL-17 and TH17 cells in chronic inflammation

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Dickkopf-1 is a master regulator of joint remodeling

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

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Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

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Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

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Tofacitinib versus Methotrexate in Rheumatoid Arthritis

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Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.

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Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

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Cutting Edge: The Conversion of Arginine to Citrulline Allows for a High-Affinity Peptide Interaction with the Rheumatoid Arthritis-Associated HLA-DRB1*0401 MHC Class II Molecule

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Ectopic lymphoid-like structures in infection, cancer and autoimmunity

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Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α‐enolase: Implications for autoimmunity in rheumatoid arthritis

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DNA methylation profiles in monozygotic and dizygotic twins

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Baricitinib in Patients with Refractory Rheumatoid Arthritis

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Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

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Invasive fibroblast‐like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

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Aggregatibacter actinomycetemcomitans –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

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Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

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The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

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Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

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Cytokines in rheumatoid arthritis — shaping the immunological landscape

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Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

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The IL-23-IL-17 axis in inflammatory arthritis

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A molecular basis for the association of the <i>HLA-DRB1</i> locus, citrullination, and rheumatoid arthritis

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Citrullination regulates pluripotency and histone H1 binding to chromatin

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Altered expression of microRNA‐203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

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Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

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Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

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Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

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Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium

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DNA methylome signature in rheumatoid arthritis

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The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

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Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis

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Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

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Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll‐like receptor 4 and Fcγ receptor

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Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

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How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

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Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles

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Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

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Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

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Role for TNF in atherosclerosis? Lessons from autoimmune disease

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Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial

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Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

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MicroRNA‐124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast‐like synoviocytes from patients with rheumatoid arthritis

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Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

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Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti–Citrullinated Protein Antibody–Positive Rheumatoid Arthritis

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The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age‐dependent manner

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Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm

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Role of the Gut Microbiome in Modulating Arthritis Progression in Mice

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Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

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How important are T cells in chronic rheumatoid synovitis?: II. T cell‐independent mechanisms from beginning to end

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Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients

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Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1–Driven Th17 Response

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Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

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Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

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The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

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Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis

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Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib

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Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis

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Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction

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Association between anti–cyclic citrullinated peptide antibodies and ischemic heart disease in patients with rheumatoid arthritis

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Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis

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Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis

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Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease

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Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

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Carbamylation-Dependent Activation of T Cells: A Novel Mechanism in the Pathogenesis of Autoimmune Arthritis

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Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients

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