The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors
Open accessAbstract
SUMMARY Autophagy and phagocytosis are conserved cellular functions involved in innate immunity. However, the nature of their interactions remains unclear. We evaluated the role of autophagy in regulating phagocytosis in macrophages from myeloid-specific autophagy-related gene 7-deficient (Atg7−/−) mice. Atg7−/− macrophages exhibited higher bacterial uptake when infected with Mycobacterium tuberculosis (Mtb) or with M. tuberculosis var. bovis BCG (BCG). In addition, BCG-infected Atg7−/− mice showed increased bacterial loads and exacerbated lung inflammatory responses. Atg7−/− macrophages had increased expression of two class A scavenger receptors: macrophage receptor with collagenous structure (MARCO) and macrophage scavenger receptor 1 (MSR1). The increase in scavenger receptors was caused by increased activity of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) transcription factor resulting from accumulated sequestosome 1 (SQSTM1 or p62) in Atg7−/− macrophages. These insights increase our understanding of the host-pathogen relationship and suggest that therapeutic strategies should be designed to include modulation of both phagocytosis and autophagy.
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“SQSTM1, also known as p62, is one of the best known substrates for autophagy (Bjørkøy et al., 2005; Pankiv et al., 2007).”
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630
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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347
Self-citationRegulation of Phagosome Maturation by Signals from Toll-Like Receptors
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Scavenger receptors: role in innate immunity and microbial pathogenesis
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Cited by
Phagocytosis: An Immunobiologic Process
Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323
Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease
Schapansky, J., Nardozzi, J. D., & LaVoie, M. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.049 · Cited by 132
Autophagy and the immune function in aging
Cuervo, A. M., & Macian, F. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.006 · Cited by 112
Metadata
- Authors
- Bonilla, D. L., Bhattacharya, A., Sha, Y., Xu, Y., Xiang, Q., Kan, A., Jagannath, C., Komatsu, M., & Eissa, N. T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 39
- Issue
- 3
- Pages
- 537-547
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1969019747
- Cited by
- 190
- References
- 9
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bonilla, D. L., Bhattacharya, A., Sha, Y., Xu, Y., Xiang, Q., Kan, A., Jagannath, C., Komatsu, M., & Eissa, N. T. (2013). Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors. Immunity. https://doi.org/10.1016/j.immuni.2013.08.026
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