The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection
Open accessAbstract
Summary Inhibitors of the transcription factor STAT3 target STAT3-dependent tumorigenesis but patients often develop diarrhea from unknown mechanisms. Here we showed that STAT3 deficiency increased morbidity and mortality after Citrobacter rodentium infection with decreased secretion of cytokines including IL-17 and IL-22 associated with the transcription factor RORγt. Administration of the cytokine IL-22 was sufficient to rescue STAT3-deficient mice from lethal infection. Although STAT3 was required for IL-22 production in both innate and adaptive arms, using conditional gene deficient mice we observed that STAT3 expression in RORγt+ innate lymphoid cells (ILC3s), but not T cells, was essential for the protection. However, STAT3 was required for RORγt expression in T helper cells, but not in ILC3s. Activated STAT3 could directly bind to the Il22 locus. Thus, cancer therapies that utilize STAT3 inhibitors increase the risk for pathogen-mediated diarrhea through direct suppression of IL-22 from gut ILCs.
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
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Self-citationSTAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043
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“We have shown that tyrosine kinase (including STAT3 pathway) inhibition suppressed both IL-22 and IL-17 expression after infection, which are required for the protection against C. rodentium infection (Ishigame et al., 2009; Ivanov et al., 2009; Wang et al., 2010; Zheng et al., 2008).”
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Genomic views of STAT function in CD4+ T helper cell differentiation
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Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Development, Differentiation, and Diversity of Innate Lymphoid Cells
Diefenbach, A., Colonna, M., & Koyasu, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.005 · Cited by 560
Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
Mao, K., Baptista, A. P., Tamoutounour, S., Zhuang, L., Bouladoux, N., Martins, A. J., Huang, Y., Gerner, M. Y., Belkaid, Y., & Germain, R. N. (2018) · Nature · doi:10.1038/nature25437 · Cited by 353
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity
Chun, E., Lavoie, S., Fonseca-Pereira, D., Bae, S., Michaud, M., Hoveyda, H. R., Fraser, G. L., Gallini Comeau, C. A., Glickman, J. N., Fuller, M. H., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.014 · Cited by 336
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 281
Metadata
- Authors
- Guo, X., Qiu, J., Tu, T., Yang, X., Deng, L., Anders, R. A., Zhou, L., & Fu, Y.-X.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 40
- Issue
- 1
- Pages
- 25-39
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2006835919
- Cited by
- 257
- References
- 8
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guo, X., Qiu, J., Tu, T., Yang, X., Deng, L., Anders, R. A., Zhou, L., & Fu, Y.-X. (2014). Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity. https://doi.org/10.1016/j.immuni.2013.10.021
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