Cited by 295Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Genomic views of STAT function in CD4+ T helper cell differentiation

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O'Shea, John J., Lahesmaa, Riitta, Vahedi, Golnaz, Laurence, Arian, Kanno, Yuka·2011·Nature Reviews Immunology

Abstract

Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.

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  1. [92]Chaudhry A CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner Science 326 986 91 2009 19797626 PMC4408196
  2. [114]Danoy P Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn’s disease PLoS Genet 6 e1001195 2010 21152001 PMC2996314

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Authors
O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y.
Affiliations
  • Åbo Akademi University (FI)
  • National Institutes of Health (US)
Venue
Nature Reviews Immunology
Published
2011-03-25
Volume
11
Issue
4
Pages
239-250
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2055082742
Cited by
295
References
148
Citations by year
2026: 7 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 27 · 2017: 15 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 26
FWCI
2.97
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041159)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
STAT proteins, cytokine signaling, epigenetic regulation, gene expression regulation, transcriptional repression, autoimmune disease, genome-wide association study
MeSH terms
Animals, Autoimmune Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Deficiency Syndromes, Lymphocyte Activation, Nucleosomes, Signal Transduction, Cytokines, Sequence Analysis, DNA, Genomics, STAT Transcription Factors, Mice, Genome-Wide Association Study

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