Genomic views of STAT function in CD4+ T helper cell differentiation
Open accessAbstract
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.
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Appropriate differentiation of CD4+ T-cell subsets requires activation of transcription factors, including STATs.
“The appropriate differentiation of these CD4+ T-cell subsets requires activation of transcription factors, including signal transducers and activators of transcription (STATs) [11].”
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
Next-generation DNA sequencing
Shendure, J., & Ji, H. (2008) · Nature Biotechnology · doi:10.1038/nbt1486 · Cited by 4,509 · see citing works
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098 · see citing works
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,185 · see citing works
A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works
Chen, X., Han, X., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.043 · Cited by 2,474 · see citing works
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450 · see citing works
Next-Generation DNA Sequencing Methods
Mardis, E. R. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164359 · Cited by 2,371 · see citing works
Combinatorial patterns of histone acetylations and methylations in the human genome
Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331 · see citing works
Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246 · see citing works
ChIP–seq: advantages and challenges of a maturing technology
Park, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2641 · Cited by 2,217 · see citing works
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086 · see citing works
Jaks and STATs: biological implications.
Leonard, W., & O'Shea, J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,939 · see citing works
Self-citationTRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works
Genome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O. M., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N. M., Kanin, E. I., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,768 · see citing works
ChIP-seq accurately predicts tissue-specific activity of enhancers
Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639 · see citing works
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634 · see citing works
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629 · see citing works
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557 · see citing works
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
Self-citationSTAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,494 · see citing works
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
Robertson, G., Hirst, M., Bainbridge, M., Bilenky, M., Zhao, Y., Zeng, T., Euskirchen, G., Bernier, B., Varhol, R., Delaney, A., et al. (2007) · Nature Methods · doi:10.1038/nmeth1068 · Cited by 1,454 · see citing works
Dynamic Regulation of Nucleosome Positioning in the Human Genome
Schones, D. E., Cui, K., Cuddapah, S., Roh, T., Barski, A., Wang, Z., Wei, G., & Zhao, K. (2008) · Cell · doi:10.1016/j.cell.2008.02.022 · Cited by 1,396 · see citing works
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388 · see citing works
Self-citationZhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., Peñaranda, C., Martínez‐Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W. L., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1774 · Cited by 1,380 · see citing works
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,338 · see citing works
Self-citationLack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., et al. (1996) · Nature · doi:10.1038/380630a0 · Cited by 1,278 · see citing works
STAT3 Mutations in the Hyper-IgE Syndrome
Holland, S. M., DeLeo, F. R., Elloumi, H. Z., Hsu, A. P., Uzel, G., Brodsky, N. N., Freeman, A. F., Demidowich, A. P., Davis, J., Turner, M. L. C., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073687 · Cited by 1,214 · see citing works
Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213 · see citing works
The JAK-STAT Signaling Pathway: Input and Output Integration
Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2623 · Cited by 1,179 · see citing works
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works
Self-citationWei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T.-Y., Watford, W. T., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.009 · Cited by 1,152 · see citing works
Self-citationCargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086 · see citing works
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., & Cua, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1698 · Cited by 1,074 · see citing works
Self-citationSTAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
Remmers, E. F., Plenge, R. M., Lee, A. T., Graham, R., Hom, G., Behrens, T. W., de Bakker, P. I. W., Le, J. M., Lee, H., Batliwalla, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073003 · Cited by 1,040 · see citing works
Th17 and regulatory T cells in mediating and restraining inflammation
Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039 · see citing works
CD4 <sup>+</sup> Regulatory T Cells Control T <sub>H</sub> 17 Responses in a Stat3-Dependent Manner
Chaudhry, A., Rudra, D., Treuting, P., Samstein, R. M., Liang, Y., Kas, A., & Rudensky, A. Y. (2009) · Science · doi:10.1126/science.1172702 · Cited by 1,000 · see citing works
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara, T., Kawamura, N., Ariga, T., Pasic, S., Stojković, O., et al. (2007) · Nature · doi:10.1038/nature06096 · Cited by 987 · see citing works
Molecular Signals of Epigenetic States
Bonasio, R., Tu, S., & Reinberg, D. (2010) · Science · doi:10.1126/science.1191078 · Cited by 912 · see citing works
Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.280 · Cited by 836 · see citing works
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
Boisson‐Dupuis, S., Jouanguy, E., Al-Hajjar, S. H., Fieschi, C., Al-Mohsen, I. Z., Aljumaah, S., Yang, K., Chapgier, A. L. A., Eidenschenk, C., Eid, P., et al. (2003) · Nature Genetics · doi:10.1038/ng1097 · Cited by 814 · see citing works
A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ
Shuai, K., Stark, G. R., Kerr, L. M., & Darnell, J. E. (1993) · Science · doi:10.1126/science.7690989 · Cited by 802 · see citing works
Zorn, E., Nelson, E. A., Mohseni, M., Porcheray, F., Kim, H. T., Litsa, D., Bellucci, R., Raderschall, E., Canning, C. M., Soiffer, R. J., et al. (2006) · Blood · doi:10.1182/blood-2006-02-004747 · Cited by 740 · see citing works
Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
Durant, L. R., Watford, W. T., Ramos, H. L., Laurence, A. D. J., Vahedi, G., Wei, L., Takahashi, H., Sun, H., Kanno, Y., Powrie, F. M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.003 · Cited by 722 · see citing works
Self-citationBauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I.-C., Sharpe, A. H., & Kuchroo, V. K. (2009) · Nature Immunology · doi:10.1038/ni.1690 · Cited by 713 · see citing works
Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity
Spolski, R. J., & Leonard, W. J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090316 · Cited by 695 · see citing works
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T. W., Kamradt, T., & Lohoff, M. D. (2007) · Nature Immunology · doi:10.1038/ni1500 · Cited by 691 · see citing works
Remmers, E. F., Coşan, F., Kirino, Y., Ombrello, M. J., Abacı, N., Satorius, C. L., Le, J. M., Yang, B. C., Korman, B. D., Çakiris, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.625 · Cited by 678 · see citing works
Self-citationGenome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Reveille, J. D., Jin, R., Zhou, X., Diekman, L., Sims, A. M., Danoy, P., Leo, P., Bradbury, L. A., Doan, T., Dowling, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.513 · Cited by 669 · see citing works
Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666 · see citing works
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works
Self-citationDeficiency of Th17 cells in hyper IgE syndrome due to mutations in <i>STAT3</i>
Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., & Cook, M. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080218 · Cited by 652 · see citing works
IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner
Wei, L., Laurence, A. D. J., Elias, K. M., & O’Shea, J. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705100200 · Cited by 639 · see citing works
Self-citationDefective Lymphoid Development in Mice Lacking Jak3
Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A., Doherty, P. C., Grosveld, G. C., & Ihle, J. N. (1995) · Science · doi:10.1126/science.270.5237.800 · Cited by 637 · see citing works
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P. N., Doi, A., Lindau, P., Lee, H.-J., Aryee, M. J., Irizarry, R. A., Kim, K., et al. (2010) · Nature · doi:10.1038/nature09367 · Cited by 636 · see citing works
Variation in Transcription Factor Binding Among Humans
Kasowski, M. M., Grubert, F., Heffelfinger, C., Hariharan, M., Asabere, A., Waszak, S., Habegger, L., Rozowsky, J., Shi, M.-Y., Urban, A., et al. (2010) · Science · doi:10.1126/science.1183621 · Cited by 625 · see citing works
The AP-1 transcription factor Batf controls TH17 differentiation
Schraml, B. U., Hildner, K., Ise, W., Lee, W.-L., Smith, W. A.-E., Solomon, B. D., Sahota, G., Sim, J. E., Mukasa, R., Čemerski, S., et al. (2009) · Nature · doi:10.1038/nature08114 · Cited by 622 · see citing works
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500168 · Cited by 616 · see citing works
Follicular Helper T Cells: Lineage and Location
Fazilleau, N., Mark, L., McHeyzer‐Williams, L. J., & McHeyzer‐Williams, M. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.003 · Cited by 593 · see citing works
Next-generation genomics: an integrative approach
Hawkins, R. D., Hon, G. C., & Ren, B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2795 · Cited by 591 · see citing works
Harris, T. J., Grosso, J. F., Yen, H., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4313 · Cited by 585 · see citing works
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works
Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works
Self-citationNonredundant roles for Stat5a/b in directly regulating Foxp3
Yao, Z., Kanno, Y., Kerenyi, M. A., Stephens, G. L., Durant, L. R., Watford, W. T., Laurence, A. D. J., Robinson, G. W., Shevach, E. M., Moriggl, R., et al. (2007) · Blood · doi:10.1182/blood-2006-11-055756 · Cited by 575 · see citing works
Self-citationPeakSeq enables systematic scoring of ChIP-seq experiments relative to controls
Rozowsky, J. S., Euskirchen, G. M., Auerbach, R. K., Zhang, Z. D., Gibson, T., Bjornson, R. D., Carriero, N., Snyder, M. P., & Gerstein, M. (2009) · Nature Biotechnology · doi:10.1038/nbt.1518 · Cited by 558 · see citing works
Liu, X., Robinson, G. W., Gouilleux, F., Groner, B., & Hennighausen, L. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8831 · Cited by 555 · see citing works
Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Mathur, A. N., Chang, H., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O’Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S., & Kaplan, M. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4901 · Cited by 548 · see citing works
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3
Thomis, D. C., Gurniak, C. B., Tivol, E. A., Sharpe, A. H., & Berg, L. J. (1995) · Science · doi:10.1126/science.270.5237.794 · Cited by 537 · see citing works
Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation
Boisson‐Dupuis, S., Dargemont, C., Fieschi, C., Thomassin, N., Rosenzweig, S. D., Harris, J., Holland, S. M., Schreiber, R. D., & Casanova, J. (2001) · Science · doi:10.1126/science.1061154 · Cited by 517 · see citing works
Zhang, F., Meng, G., & Strober, W. (2008) · Nature Immunology · doi:10.1038/ni.1663 · Cited by 501 · see citing works
Wolk, K., Witte, E., Witte, K., Warszawska, K., & Sabat, R. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0188-x · Cited by 395 · see citing works
Blat, Y., & Kleckner, N. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81019-3 · Cited by 390 · see citing works
Stat5 Activation Plays a Critical Role in Th2 Differentiation
Zhu, J., Cote-Sierra, J., Guo, L., & Paul, W. E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00292-9 · Cited by 384 · see citing works
Kwon, H., Thierry‐Mieg, D., Thierry‐Mieg, J., Kim, H., Oh, J., Tunyaplin, C., Carotta, S., Donovan, C. E., Goldman, M. L., Tailor, P. B., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.008 · Cited by 357 · see citing works
Schmitt, N., Morita, R., Bourdery, L., Bentebibel, S.-E., Zurawski, S., Banchereau, J., & Ueno, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.016 · Cited by 357 · see citing works
Roles of STAT3 defined by tissue-specific gene targeting
Akira, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203478 · Cited by 345 · see citing works
Biologic consequences of Stat1-independent IFN signaling
Gil, M. P., Bohn, E., O'Guin, A. K., Ramana, C. V., Levine, B., Stark, G. R., Virgin, H. W., & Schreiber, R. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111163898 · Cited by 345 · see citing works
Hegazy, A. N., Peine, C., Helmstetter, C., Panse, I., Fröhlich, A., Bergthaler, A., Flatz, L., Pinschewer, D. D., Radbruch, A., & Löhning, M. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.004 · Cited by 341 · see citing works
Regulation of MicroRNA Expression and Abundance during Lymphopoiesis
Kuchen, S., Resch, W., Yamane, A., Kuo, N., Li, Z., Chakraborty, T., Wei, L., Laurence, A. D. J., Yasuda, T., Peng, S., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.009 · Cited by 324 · see citing works
Self-citationWei, L., Vahedi, G., Sun, H., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H., Liang, J. Z., Gutierrez-Cruz, G., Zang, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.003 · Cited by 322 · see citing works
Self-citationAkimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works
Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion
Zhu, J., Guo, L., Watson, C. J., Hu-Li, J., & Paul, W. E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7276 · Cited by 301 · see citing works
Loss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases
Liu, X., Lee, Y. S., Yu, C., & Egwuagu, C. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6070 · Cited by 290 · see citing works
Liao, W., Schones, D. E., Oh, J., Cui, Y., Cui, K., Roh, T., Zhao, K., & Leonard, W. J. (2008) · Nature Immunology · doi:10.1038/ni.1656 · Cited by 287 · see citing works
Cho, S. S., Bacon, C. M., Sudarshan, C., Rees, R. C., Finbloom, D. S., Pine, R. I., & O’Shea, J. J. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.11.4781 · Cited by 272 · see citing works
Self-citationNishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm045 · Cited by 268 · see citing works
Zhang, Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T., & Wasik, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501959102 · Cited by 263 · see citing works
Stat1-independent regulation of gene expression in response to IFN-γ
Ramana, C. V., Gil, M. P., Han, Y., Ransohoff, R. M., Schreiber, R. D., & Stark, G. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111164198 · Cited by 244 · see citing works
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer
Naoe, Y., Setoguchi, R., Akiyama, K., Muroi, S., Kuroda, M., Hatam, F., Littman, D. R., & Taniuchi, I. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062456 · Cited by 242 · see citing works
Minegishi, Y., Saitō, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082767 · Cited by 242 · see citing works
Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation
Grimley, P. M. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00011-8 · Cited by 240 · see citing works
Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
Betz, B. C., Jordan-Williams, K. L., Wang, C., Kang, S. G., Liao, J., Logan, M. R., Kim, C. H., & Taparowsky, E. J. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091548 · Cited by 240 · see citing works
Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T., Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.003 · Cited by 237 · see citing works
Cohen, A. C., Nadeau, K. C., Tu, W., Hwa, V., Dionis, K. Y., Bezrodnik, L., Teper, A., Gaillard, M., Heinrich, J. J., Krensky, A. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2770 · Cited by 236 · see citing works
Finding distal regulatory elements in the human genome
Heintzman, N. D., & Ren, B. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.09.006 · Cited by 234 · see citing works
RUNX proteins in transcription factor networks that regulate T-cell lineage choice
Collins, A., Littman, D. R., & Taniuchi, I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2489 · Cited by 219 · see citing works
Single-molecule DNA sequencing technologies for future genomics research
Gupta, P. K. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.07.003 · Cited by 219 · see citing works
Mapping accessible chromatin regions using Sono-Seq
Auerbach, R. K., Euskirchen, G. M., Rozowsky, J. S., Lamarre-Vincent, N., Moqtaderi, Z., Lefrançois, P., Struhl, K., Gerstein, M., & Snyder, M. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905443106 · Cited by 205 · see citing works
Antov, A., Yang, L., Vig, M., Baltimore, D., & Parijs, L. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3435 · Cited by 204 · see citing works
Maintaining Cell Identity through Global Control of Genomic Organization
Natoli, G. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.006 · Cited by 199 · see citing works
STAT4: A Critical Regulator of Inflammation In Vivo
Kaplan, M. H. (2005) · Immunologic Research · doi:10.1385/ir:31:3:231 · Cited by 192 · see citing works
Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites
Crawford, G. E., Holt, I. E., Mullikin, J. C., Tai, D. S., Green, E. D., Wolfsberg, T. G., & Collins, F. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307540100 · Cited by 182 · see citing works
Robertson, A. G., Bilenky, M., Tam, A., Zhao, Y., Zeng, T., Thiessen, N., Cezard, T., Fejes, A. P., Wederell, E. D., Cullum, R., et al. (2008) · Genome Research · doi:10.1101/gr.078519.108 · Cited by 182 · see citing works
Histone demethylase KDM5A is an integral part of the core Notch–RBP-J repressor complexPreprint
Liefke, R., Oswald, F., Alvarado, C., Ferrés-Marcó, D., Mittler, G., Rodriguez, P., Domínguez, M., & Borggrefe, T. (2010) · Genes & Development · doi:10.1101/gad.563210 · Cited by 181 · see citing works
Miyagi, T., Gil, M. P., Wang, X., Louten, J., Chu, W., & Biron, C. A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070401 · Cited by 175 · see citing works
Variant form of STAT4 is associated with primary Sjögren's syndrome
Korman, B. D., Alba, M., Le, J. M., Alevizos, I., Smith, J. A., Nikolov, N. P., Kastner, D. L., Remmers, E. F., & Illei, G. G. (2008) · Genes and Immunity · doi:10.1038/gene.2008.1 · Cited by 174 · see citing works
Elo, L. L., Järvenpää, H., Tuomela, S., Raghav, S. K., Ahlfors, H., Laurila, K., Gupta, B., Lund, R., Tahvanainen, J., Hawkins, R. D., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.011 · Cited by 155 · see citing works
Self-citationChromaSig: A Probabilistic Approach to Finding Common Chromatin Signatures in the Human Genome
Hon, G. C., Ren, B., & Wang, W. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000201 · Cited by 152 · see citing works
Takaki, H., Ichiyama, K., Koga, K., Chinen, T., Takaesu, G., Sugiyama, Y., Kato, S., Yoshimura, A., & Kobayashi, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801123200 · Cited by 151 · see citing works
Characterization of human epigenomes
Wang, Z., Schones, D. E., & Zhao, K. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.02.001 · Cited by 151 · see citing works
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
Shi, S., Larson, K., Guo, D., Lim, S. J., Dutta, P., Yan, S., & Li, W. X. (2008) · Nature Cell Biology · doi:10.1038/ncb1713 · Cited by 144 · see citing works
Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
Filer, C., Ho, P., Smith, R., Griffiths, C. E. M., Young, H. S., Worthington, J., Bruce, I. N., & Barton, A. C. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24128 · Cited by 140 · see citing works
Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries
Sabo, P. J., Humbert, R., Hawrylycz, M., Wallace, J. C., Dorschner, M. O., McArthur, M., & Stamatoyannopoulos, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400678101 · Cited by 134 · see citing works
Komine, O., Hayashi, K., Natsume, W., Watanabe, T., Seki, Y., Seki, N., Yagi, R., Sukzuki, W., Tamauchi, H., Hozumi, K., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021200 · Cited by 133 · see citing works
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
Walker, S. R., Nelson, E. A., & Frank, D. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209775 · Cited by 125 · see citing works
Dynamic and Transient Remodeling of the Macrophage IL-10 Promoter during Transcription
Zhang, X., Edwards, J. P., & Mosser, D. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1282 · Cited by 122 · see citing works
Identification of Novel IL-4/Stat6-Regulated Genes in T Lymphocytes
Chen, Z. J., Lund, R., Aittokallio, T. A., Kosonen, M., Nevalainen, O., & Lahesmaa, R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3627 · Cited by 107 · see citing works
Self-citationNine lives: plasticity among T helper cell subsets
Locksley, R. M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091442 · Cited by 103 · see citing works
Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL‐12 responses
Hoey, T. C., Zhang, S., Schmidt, N. W., Yu, Q., Ramchandani, S., Xu, X. M., Naeger, L. K., Sun, Y., & Kaplan, M. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg393 · Cited by 93 · see citing works
Early Target Genes of IL-12 and STAT4 Signaling in Th Cells
Lund, R., Chen, Z. J., Scheinin, J., & Lahesmaa, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6775 · Cited by 91 · see citing works
Self-citationLinking cell signaling and the epigenetic machinery
Mohammad, H. P., & Baylin, S. B. (2010) · Nature Biotechnology · doi:10.1038/nbt1010-1033 · Cited by 84 · see citing works
Hellquist, A., Järvinen, T. M., Koskenmies, S., Zucchelli, M., Orsmark‐Pietras, C., Berglind, L., Panelius, J., Hasan, T., Julkunen, H. A., D’Amato, M., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081160 · Cited by 80 · see citing works
Prolactin Inhibits BCL6 Expression in Breast Cancer through a Stat5a-Dependent Mechanism
Tran, T. H., Utama, F. E., Lin, J., Yang, N., Sjolund, A. B., Ryder, A., Johnson, K. J., Neilson, L. M., Liu, C., Brill, K. L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2314 · Cited by 78 · see citing works
Good, S. R., Thieu, V. T., Mathur, A. N., Yu, Q., Stritesky, G. L., Yeh, N., O’Malley, J. T., Perumal, N. B., & Kaplan, M. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901411 · Cited by 74 · see citing works
Glas, J., Seiderer, J., Nagy, M. S., Fries, C., Beigel, F., Weidinger, M., Pfennig, S., Klein, W., Epplen, J. T., Lohse, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010373 · Cited by 63 · see citing works
Lineage specification and heterogeneity of T follicular helper cells
Yu, D., Batten, M., Mackay, C. R., & King, C. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.09.013 · Cited by 61 · see citing works
Takatori, H., Nakajima, H., Kagami, S., Hirose, K., Suto, A., Suzuki, K., Kubo, M., Yoshimura, A., Saito, Y., & Iwamoto, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4105 · Cited by 56 · see citing works
O’Malley, J. T., Sehra, S., Thieu, V. T., Yu, Q., Chang, H., Stritesky, G. L., Nguyen, E., Mathur, A. N., Levy, D. E., & Kaplan, M. H. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.03037.x · Cited by 55 · see citing works
van de Veerdonk, F. L., Marijnissen, R. J., Joosten, L. A. B., Kullberg, B. J., Drenth, J. P. H., Netea, M. G., & van der Meer, J. W. M. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04043.x · Cited by 37 · see citing works
Uemura, A., Takehara, T., Miyagi, T., Suzuki, T., Tatsumi, T., Ohkawa, K., Kanto, T., Hiramatsu, N., & Hayashi, N. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0764-x · Cited by 31 · see citing works
Identification of novel Stat6 regulated proteins in IL‐4‐treated mouse lymphocytes
Tuomela, S., Rautajoki, K. J., Moulder, R., Nyman, T. A., & Lahesmaa, R. (2009) · PROTEOMICS · doi:10.1002/pmic.200800161 · Cited by 16 · see citing works
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- [92]Chaudhry A CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner Science 326 986 91 2009 19797626 PMC4408196
- [114]Danoy P Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn’s disease PLoS Genet 6 e1001195 2010 21152001 PMC2996314
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Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
O’Shea, J. J., & Plenge, R. M. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.014 · Cited by 1,146 · see citing works
Self-citationMechanisms of Jak/STAT Signaling in Immunity and Disease
Villarino, A. V., Kanno, Y., Ferdinand, J. R., & O’Shea, J. J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401867 · Cited by 554 · see citing works
Self-citationMumbach, M. R., Satpathy, A. T., Boyle, E. A., Dai, C., Gowen, B. G., Cho, S. W., Nguyen, M. L., Rubin, A. J., Granja, J. M., Kazane, K. R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3963 · Cited by 490 · see citing works
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Hirahara, K., & Nakayama, T. (2016) · International Immunology · doi:10.1093/intimm/dxw006 · Cited by 417 · see citing works
Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.017 · Cited by 410 · see citing works
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Muranski, P. J., & Restifo, N. P. (2013) · Blood · doi:10.1182/blood-2012-09-378653 · Cited by 386 · see citing works
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Loh, C.-Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00048 · Cited by 351 · see citing works
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Roy, D. G., Chen, J., Mamane, V. H., Ma, E. H., Muhire, B. M., Sheldon, R. D., Shorstova, T., Koning, R., Johnson, R. M., Esaulova, E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.006 · Cited by 347 · see citing works
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Coskun, M., Salem, M. A., Pedersen, J., & Nielsen, O. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.06.007 · Cited by 327 · see citing works
Bao, L., Zhang, H., & Chan, L. S. (2013) · JAK-STAT · doi:10.4161/jkst.24137 · Cited by 321 · see citing works
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Nakayamada, S., Takahashi, H., Kanno, Y., & O’Shea, J. J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.014 · Cited by 317 · see citing works
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Mahoney, J. M., Taroni, J., Martyanov, V., Wood, T. A., Greene, C. S., Pioli, P. A., Hinchcliff, M., & Whitfield, M. L. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004005 · Cited by 153 · see citing works
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Zhao, Y., Chu, X., Chen, J., Wang, Y., Gao, S., Jiang, Y., Zhu, X., Tan, G., Zhao, W., Yi, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12368 · Cited by 144 · see citing works
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Zhu, E., Wang, X., Zheng, B., Wang, Q., Hao, J., Chen, S., Zhao, Q., Zhao, L., Wu, Z., & Yin, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303488 · Cited by 125 · see citing works
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Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., & Nakayama, T. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.11.003 · Cited by 124 · see citing works
Immune markers and differential signaling networks in ulcerative colitis and Crohnʼs disease
Christophi, G. P., Rong, R., Holtzapple, P. G., Massa, P. T., & LANDAS, S. K. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22957 · Cited by 121 · see citing works
Nakayamada, S., Poholek, A. C., Lu, K. T., Takahashi, H., Kato, M. G., Iwata, S., Hirahara, K., Cannons, J. L., Schwartzberg, P. L., Vahedi, G., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300675 · Cited by 122 · see citing works
Self-citationHall, A. O., Silver, J. S., & Hunter, C. A. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394299-9.00001-1 · Cited by 120 · see citing works
Adoue, V., Binet, B., Malbec, A., Fourquet, J., Romagnoli, P., van Meerwijk, J. P. M., Amigorena, S., & Joffre, O. P. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.003 · Cited by 113 · see citing works
Transcriptional and epigenetic regulation of T‐helper lineage specification
Tripathi, S. K., & Lahesmaa, R. (2014) · Immunological Reviews · doi:10.1111/imr.12204 · Cited by 111 · see citing works
Self-citationLiu, H., Yao, S., Dann, S. M., Qin, H., Elson, C. O., & Cong, Y. (2013) · European Journal of Immunology · doi:10.1002/eji.201242889 · Cited by 112 · see citing works
The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus
Goropevšek, A., Holcar, M., & Avčin, T. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8550-y · Cited by 110 · see citing works
Powell, M. D., Read, K. A., Sreekumar, B. K. N., & Oestreich, K. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01299 · Cited by 110 · see citing works
Helper T‐cell identity and evolution of differential transcriptomes and epigenomes
Vahedi, G., Poholek, A. C., Hand, T. W., Laurence, A. D. J., Kanno, Y., O’Shea, J. J., & Hirahara, K. (2013) · Immunological Reviews · doi:10.1111/imr.12037 · Cited by 109 · see citing works
Self-citationLong-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7
Vergani, A., Tezza, S., D’Addio, F., Fotino, C., Liu, K., Niewczas, M. A., Bassi, R., Molano, R. D., Kleffel, S., Petrelli, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.123653 · Cited by 108 · see citing works
Delgoffe, G. M., & Vignali, D. (2013) · JAK-STAT · doi:10.4161/jkst.23060 · Cited by 62 · see citing works
TGF‐β converts Th1 cells into Th17 cells through stimulation of Runx1 expression
Liu, H., Cao, A., Feng, T., Li, Q., Zhang, W., Yao, S., Dann, S. M., Elson, C. O., & Cong, Y. (2015) · European Journal of Immunology · doi:10.1002/eji.201444726 · Cited by 104 · see citing works
Gray, S. M., Kaech, S. M., & Staron, M. M. (2014) · Immunological Reviews · doi:10.1111/imr.12205 · Cited by 100 · see citing works
Transcriptional mechanisms that regulate T helper 1 cell differentiation
Oestreich, K. J., & Weinmann, A. S. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.004 · Cited by 99 · see citing works
Grabowska, A. K. (2012) · The Open Virology Journal · doi:10.2174/1874357901206010249 · Cited by 99 · see citing works
An, H., Kim, J., Kim, W., Gwon, M., Gu, H. M., Jeon, M. J., Han, S., Pak, S. C., Lee, C., Park, I. S., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14487 · Cited by 98 · see citing works
mTOR, linking metabolism and immunity
Xu, X., Ye, L., Araki, K., & Ahmed, R. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.005 · Cited by 96 · see citing works
Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA
Masuda, K., Ripley, B., Nyati, K. K., Dubey, P. K., Zaman, M. M.-U., Hanieh, H., Higa, M., Yamashita, K., Standley, D. M., Mashima, T., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151289 · Cited by 95 · see citing works
Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., Yang, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287857 · Cited by 92 · see citing works
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses
Knosp, C. A., Carroll, H. P., Elliott, J., Saunders, S. P., Nel, H. J., Amu, S., Pratt, J. C., Spence, S., Doran, E., Cooke, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101167 · Cited by 84 · see citing works
Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells
Lund, P. J., Elias, J. E., & Davis, M. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502031 · Cited by 83 · see citing works
Yamamura, K., Uruno, T., Shiraishi, A., Tanaka, Y., Ushijima, M., Nakahara, T., Watanabe, M., Kido‐Nakahara, M., Tsuge, I., Furue, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms13946 · Cited by 82 · see citing works
The transcription factor network in Th9 cells
Kaplan, M. H. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0600-2 · Cited by 81 · see citing works
Özdemir, A. T., Özdemir, R. B. Ö., Kırmaz, C., Sarıboyacı, A. E., HALBUTOĞULLARI, Z. S., Özel, C., & Karaöz, E. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.08.008 · Cited by 80 · see citing works
STAT signaling in inflammation
Kaplan, M. H. (2013) · JAK-STAT · doi:10.4161/jkst.24198 · Cited by 80 · see citing works
Kim, K., Srikanth, S., Tan, Y., Yee, M.-K. W., Jew, M., Damoiseaux, R. D., Jung, M. E., Shimizu, S., An, D. S., Ribalet, B., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302586 · Cited by 79 · see citing works
Hutchins, A. P., Díez, D., Takahashi, Y., Ahmad, S., Jauch, R., Tremblay, M. L., & Miranda‐Saavedra, D. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1300 · Cited by 80 · see citing works
Influences of the Gut Microbiota on DNA Methylation and Histone Modification
Ye, J., Wu, W., Li, Y., & Li, L. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4538-6 · Cited by 79 · see citing works
Multi-level remodelling of chromatin underlying activation of human T cells
Bediaga, N. G., Coughlan, H. D., Johanson, T. M., Garnham, A. L., Naselli, G., Schröder, J., Fearnley, L. G., Bandala‐Sanchez, E., Allan, R. S., Smyth, G. K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80165-9 · Cited by 80 · see citing works
Regulation of CD4 + T‐cell polarization by suppressor of cytokine signalling proteins
Knosp, C. A., & Johnston, J. A. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03520.x · Cited by 75 · see citing works
Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus
Hu, J., Zhang, J., Cui, J.-L., Liang, X., Lü, R., Du, G., Xu, X.-Y., & Zhou, G. (2013) · Cytokine · doi:10.1016/j.cyto.2013.01.020 · Cited by 74 · see citing works
Chen, M., Xiao, C., Lao, X., Yuan, W., Liu, R., Zeng, Q., Wang, J., Ouyang, F., Chen, D., Chan, K., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0329 · Cited by 74 · see citing works
Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation
Komori, H. K., Hart, T., LaMere, S. A., Chew, P. V., & Salomon, D. R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401162 · Cited by 71 · see citing works
Ullah, U., Andrabi, S. B. A., Tripathi, S. K., Dirasantha, O., Kanduri, K., Rautio, S., Groß, C. C., Lehtimäki, S., Bala, K., Tuomisto, J. E. E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.070 · Cited by 73 · see citing works
Self-citationThe Rigid Amphipathic Fusion Inhibitor dUY11 Acts through Photosensitization of Viruses
Vigant, F., Hollmann, A., Lee, J., Santos, N. C., Jung, M. E., & Lee, B. (2013) · Journal of Virology · doi:10.1128/jvi.02907-13 · Cited by 70 · see citing works
Fiocco, U., Accordi, B., Martini, V., Oliviero, F., Facco, M., Cabrelle, A., Piva, L., Molena, B., Caso, F., Costa, L., et al. (2014) · Immunologic Research · doi:10.1007/s12026-013-8481-0 · Cited by 70 · see citing works
Glycan-Modified Virus-like Particles Evoke T Helper Type 1-like Immune Responses
Alam, M. M., Jarvis, C. M., Hincapie, R., McKay, C. S., Schimer, J., Sanhueza, C., Xu, K., Diehl, R. C., Finn, M. G., & Kiessling, L. L. (2020) · ACS Nano · doi:10.1021/acsnano.0c03023 · Cited by 65 · see citing works
Kang, K., Robinson, G., & Hennighausen, L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-4 · Cited by 72 · see citing works
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species
Maródi, L., Cypowyj, S., Tóth, B., Chernyshova, L. I., Puel, A., & Casanova, J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.011 · Cited by 67 · see citing works
The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes
Pandiyan, P., Yang, X., Saravanamuthu, S. S., Zheng, L., Ishihara, S., O’Shea, J. J., & Lenardo, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201476 · Cited by 66 · see citing works
Self-citationCellular Plasticity of CD4+ T Cells in the Intestine
Brucklacher-Waldert, V., Carr, E. J., Linterman, M. A., & Veldhoen, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00488 · Cited by 66 · see citing works
Interplay of Th1 and Th17 Cells in Murine Models of Malignant Pleural Effusion
Lin, H., Tong, Z.-H., Xu, Q., Wu, X., Wang, X., Jin, X.-G., Ma, W., Cheng, X. C., Zhou, Q., & Shi, H. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201310-1776oc · Cited by 64 · see citing works
Interleukin-31 and Pruritic Skin
Furue, M., & Furue, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091906 · Cited by 61 · see citing works
The spectrum of STAT functions in mammary gland development
Hughes, K., & Watson, C. J. (2012) · JAK-STAT · doi:10.4161/jkst.19691 · Cited by 60 · see citing works
Plank, M. W., Maltby, S., Mattes, J., & Foster, P. S. (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12135 · Cited by 60 · see citing works
Interferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence
Chung, H., Green, P. H. R., Wang, T. C., & Kong, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s280953 · Cited by 59 · see citing works
Coghill, J. M., Fowler, K. A., West, M. L., Fulton, L. M., Deventer, H. V., McKinnon, K. P., Vincent, B. G., Lin, K. L., Panoskaltsis‐Mortari, A., Cook, D. N., et al. (2013) · Blood · doi:10.1182/blood-2012-06-435735 · Cited by 56 · see citing works
MicroRNA-155-IFN-γ Feedback Loop in CD4+T Cells of Erosive type Oral Lichen Planus
Hu, J., Zhang, J., Ma, J., Liang, X., Chen, G.-Y., Lü, R., Du, G., & Zhou, G. (2015) · Scientific Reports · doi:10.1038/srep16935 · Cited by 55 · see citing works
Kim, B.-H., Na, K.-M., Oh, I., Song, I., Lee, Y. S., Shin, J., & Kim, T. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.01.005 · Cited by 54 · see citing works
Regulation of Foxp3+ Inducible Regulatory T Cell Stability by SOCS2
Knosp, C. A., Schiering, C., Spence, S., Carroll, H. P., Nel, H. J., Osbourn, M., Jackson, R. P., Lyubomska, O., MALISSEN, B., Ingram, R. J., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201396 · Cited by 54 · see citing works
Epigenetic biomarkers: a step forward for understanding periodontitis
Lindroth, A. M., & Park, Y. J. (2013) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2013.43.3.111 · Cited by 54 · see citing works
Li, J., Zhang, L., Zhang, J., Wei, Y., Li, K., Huang, L., Zhang, S., Gao, B., Wang, X., & Lin, P. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs384 · Cited by 54 · see citing works
Weathering the storm; a review of pre-pregnancy stress and risk of spontaneous abortion
Frazier, T., HOGUE, C. J. R., Bonney, E. A., Yount, K. M., & Pearce, B. D. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.001 · Cited by 53 · see citing works
Current understanding of Th2 cell differentiation and function
Li, Z., Zhang, Y., & Sun, B. (2011) · Protein & Cell · doi:10.1007/s13238-011-1083-5 · Cited by 50 · see citing works
Zinc deficiency drives Th17 polarization and promotes loss of Treg cell function
Kulik, L., Maywald, M., Kloubert, V., Weßels, I., & Rink, L. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.011 · Cited by 50 · see citing works
Chen, J., Zhao, Y., Jiang, Y., Gao, S., Wang, Y., Wang, D., Wang, A., Yi, H., Gu, R., Yi, Q., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01787 · Cited by 49 · see citing works
Koh, B., Hufford, M. M., Pham, D., Olson, M. R., Wu, T., Jabeen, R., Sun, X., & Kaplan, M. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502383 · Cited by 49 · see citing works
A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells
Hong, T., Xing, J., Li, L., & Tyson, J. J. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-66 · Cited by 49 · see citing works
Shao, Y., Zhou, Y.-M., Hu, M. S., Li, J., Chen, C., Wang, Y., Shi, X., Wang, W., & Zhang, T. (2017) · Molecules · doi:10.3390/molecules22030504 · Cited by 48 · see citing works
Cytokine Signaling: Birth of a Pathway
O’Shea, J. J., Gadina, M., & Kanno, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102913 · Cited by 47 · see citing works
Self-citationMcMichael, E. L., Benner, B. N., Atwal, L. S., Courtney, N. B., Mo, X. M., Davis, M. E., Campbell, A. R., Duggan, M. C., Williams, K., Martin, K. A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2108 · Cited by 46 · see citing works
Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis
Li, Z.-H., Wang, Y., He, D., Zhang, X., Zhou, Y., Yue, H., Huang, S., Fu, Z., Zhang, L., Mao, Z., et al. (2019) · Aging · doi:10.18632/aging.102093 · Cited by 46 · see citing works
An autoregulatory enhancer controls mammary-specific STAT5 functions
Metser, G., Shin, H. Y., Wang, C., Yoo, K. H., Oh, S., Villarino, A. V., O’Shea, J. J., Kang, K., & Hennighausen, L. G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv999 · Cited by 45 · see citing works
Self-citationQuan, L., Lan, X., Meng, Y., Guo, X., Guo, Y., Zhao, L., Chen, X., & Liu, A. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.01.003 · Cited by 44 · see citing works
Maywald, M., Wang, F., & Rink, L. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.02.004 · Cited by 44 · see citing works
Recent advances in the epigenetics and genomics of asthma
Koppelman, G. H., & Nawijn, M. C. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834a9573 · Cited by 43 · see citing works
In Vitro Differentiation of Effector CD4+ T Helper Cell Subsets
Read, K. A., Powell, M. D., Sreekumar, B. K. N., & Oestreich, K. J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9167-9_6 · Cited by 43 · see citing works
Transcriptional network profile on synovial fluid T cells in psoriatic arthritis
Fiocco, U., Martini, V., Accordi, B., Caso, F., Costa, L., Oliviero, F., Scanu, A., Facco, M., Boso, D., Gatto, M., et al. (2015) · Clinical Rheumatology · doi:10.1007/s10067-015-3002-2 · Cited by 43 · see citing works
B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis
Zeng, Q., Yuan, W., Lao, X., Chen, D., Huang, C.-X., Lin, Q., He, M. Y., Liao, Y., Zheng, L., Li, B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb6296 · Cited by 42 · see citing works
- Authors
- O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y.
- Affiliations
- Åbo Akademi University (FI)
- National Institutes of Health (US)
- Venue
- Nature Reviews Immunology
- Published
- 2011-03-25
- Volume
- 11
- Issue
- 4
- Pages
- 239-250
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3070307
- OpenAlex
- W2055082742
- Cited by
- 295
- References
- 148
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 24 · 2018: 27 · 2017: 15 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 26
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041159)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT proteins, cytokine signaling, epigenetic regulation, gene expression regulation, transcriptional repression, autoimmune disease, genome-wide association study
- MeSH terms
- Animals, Autoimmune Diseases, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Deficiency Syndromes, Lymphocyte Activation, Nucleosomes, Signal Transduction, Cytokines, Sequence Analysis, DNA, Genomics, STAT Transcription Factors, Mice, Genome-Wide Association Study
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