Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

Rajsbaum, Ricardo, Versteeg, Gijs A., Schmid, Sonja, Maestre, Ana M., Belicha-Villanueva, Alan, Martínez-Romero, Carles, Patel, Jenish R., Morrison, Juliet, Pisanelli, Giuseppe, Miorin, Lisa, Laurent-Rolle, Maudry, Moulton, Hong M., Stein, David A., Fernandez-Sesma, Ana, tenOever, Benjamin R., García-Sastre, Adolfo·2014·Immunity

Cited by (163)

Items 101–163 of 163

  1. Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses
    Widad Dantoft, Pablo Martínez‐Vicente, James Jafali, Lara Pérez‐Martínez, K. Martin, Konstantinos Kotzamanis, Marie Craigon, Manfred Auer, Neil T. Young, Paul Walsh et al. · 2017 · Frontiers in Immunology
  2. Tripartite motif‐containing proteins precisely and positively affect host antiviral immune response
    Yunan Wei, Shun Chen, Mengyue Wang, Anchun Cheng · 2018 · Scandinavian Journal of Immunology
  3. Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ
    Xiaolian Cai, Rui Wang, Junji Zhu, Xiong Li, Xing Liu, Gang Ouyang, Jing Wang, Zhi Li, Chunchun Zhu, Hongyan Deng et al. · 2023 · Cell Reports
  4. Small molecules targeting ubiquitination to control inflammatory diseases
    Zheng-Qing Li, Xiuping Chen, Ying Wang · 2021 · Drug Discovery Today
  5. TRIM25 negatively regulates IKKε-mediated interferon signaling in black carp
    Can Yang, Juanjuan Shu, Yujia Miao, Xiaoyu Liu, Tianle Zheng, Ruixin Hou, Jun Xiao, Hao Feng · 2023 · Fish & Shellfish Immunology
  6. Patterns of Evolution of TRIM Genes Highlight the Evolutionary Plasticity of Antiviral Effectors in Mammals
    Alexandre P. Fernandes, Molly OhAinle, Pedro José Esteves · 2023 · Genome Biology and Evolution
  7. The Ubiquitin Tale: Current Strategies and Future Challenges
    Arun Upadhyay, Vibhuti Joshi · 2024 · ACS Pharmacology & Translational Science
  8. DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples
    Sara Pischedda, Alberto Gómez‐Carballa, Jacobo Pardo‐Seco, Sandra Viz-Lasheras, Alba Camino‐Mera, Xabier Bello, María José Currás-Tuala, Irene Rivero Calle, Ana Isabel Dacosta-Urbieta, Federico Martinón‐Torres et al. · 2025 · Epigenetics & Chromatin
  9. Emerging roles of tripartite motif family proteins ( TRIMs ) in breast cancer
    Jianing Cao, Mengdi Yang, Duancheng Guo, Zhonghua Tao, Xichun Hu · 2024 · Cancer Medicine
  10. TRIMming down Flavivirus Infections
    Marion Cannac, Sébastien Nisole · 2024 · Viruses
  11. Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice
    Ricardo Rajsbaum · 2017 · Methods in molecular biology
  12. Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
    Qi Chen, Peiguo Yang · 2025 · Cell Reports
  13. Procyanidin B2 alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the NF-κB/JAK2/STAT1 signaling pathway
    Hui Wan, Yuxin Zhang, Zhicheng Gao, Guanyue Shan, Jianing Yin, Haijun Li · 2025 · European Journal of Pharmacology
  14. Ubiquitination and autophagy in host–pathogen interactions: from immune surveillance to therapeutic targeting
    João Mello-Vieira, Ivan Đikić · 2026 · Nature reviews. Immunology
  15. Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases
    Ankur Rakesh Dubey, Yuvraj Anandrao Jagtap, Prashant Kumar, Som Mohanlal Patwa, Sumit Kinger, Amit Kumar, Sarika Singh, Amit Prasad, Nihar Ranjan Jana, Amit Mishra · 2021 · Journal of Cellular Biochemistry
  16. La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation
    Giuseppe Pisanelli, Maudry Laurent-Rolle, Balaji Manicassamy, Alan Belicha‐Villanueva, Juliet M. Morrison, Bernardo Lozano-Dubernard, Felipa Castro-Peralta, Giuseppe Iovane, Adolfo García‐Sastre · 2015 · Virus Research
  17. Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1
    Tomoki Sorada, Daichi Morimoto, Erik Walinda, Kenji Sugase · 2021 · Biochemical and Biophysical Research Communications
  18. Molecular characterization and functional analysis of TRIM37 from black tiger shrimp (Penaeus monodon)
    Chao Zhao, Chao Peng, Pengfei Wang, Bo Zhang, Lulu E. Yan, Chunlin Wang, Lihua Qiu · 2023 · Fish & Shellfish Immunology
  19. The Dual Role of TRIM7 in Viral Infections
    María González-Orozco, Carlos Andrés Rodríguez-Salazar, María I. Giraldo · 2024 · Viruses
  20. Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology
    Qing-Ao Xiao, Qian He, Lun Li, Yinhong Song, Yue-ran Chen, Jun Zeng, Xuan Xia · 2022 · Frontiers in Pharmacology
  21. Aggregation and Disaggregation of Morpholino Oligomers in Solution
    Garrick Chow, Paul A. Morcos, Hong M. Moulton · 2017 · Methods in molecular biology
  22. USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3
    Zigang Qiao, Dapei Li, Fan Zhang, Jingfei Zhu, Siying Liu, Xue Bai, Haiping Yao, Zhengrong Chen, Yongdong Yan, Xiulong Xu et al. · 2025 · PLoS Pathogens
  23. Early Pregnancy Regulates Expression of IkappaB Family in Ovine Spleen and Lymph Nodes
    Shengya Fang, Chunjiang Cai, Ying Bai, Leying Zhang, Ling Yang · 2023 · International Journal of Molecular Sciences
  24. Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-like Receptors
    Sarah van Tol, Adam Hage, Ricardo Rajsbaum, Alexander N. Freiberg · 2023 · Viruses
  25. TRIM6 promotes glioma malignant progression by enhancing FOXO3A ubiquitination and degradation
    Jingpeng Guo, Ji Wang, Peng Zhang, Ping Wen, Shoudan Zhang, Xuchen Dong, Jun Dong · 2024 · Translational Oncology
  26. Henipavirus Infection: Natural History and the Virus-Host Interplay
    Glenn A. Marsh, Hans Jürgen Netter · 2018 · Current treatment options in infectious diseases/Current treatment options in infectious disease
  27. The Structural Features of Henipavirus Matrix Protein Driving Intracellular Trafficking
    Camilla M. Donnelly, Justin A. Roby, Christopher Scott, Shane Raidal, Jade Kenneth Forwood · 2020 · Viral Immunology
  28. Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε
    Zifeng Zheng, Yuncheng Li, Mudan Zhang, Yalan Liu, Ming Fu, Sitang Gong, Qinxue Hu · 2021 · Frontiers in Microbiology
  29. Methylation profile of individuals with sickle cell trait
    Ana Gabriela Vasconcelos, Mari Johnson, Yanwei Cai, Li Hsu, Nora Franceschini, Paul Livermore Auer, Charles L Kooperberg, Laura M. Raffield, Alex P. Reiner · 2025 · Epigenetics
  30. NS5 hijacks TRAF3 to inhibit type I interferon signaling during duck Tembusu virus infection
    Wenjun Cai, Yuhong Pan, Wanshuang Luo, Anchun Cheng, Mingshu Wang, Shun Chen, Juan Huang, Qiao Yang, Ying Wu, Di Sun et al. · 2023 · Veterinary Microbiology
  31. A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases
    Adam Hage, Mikhaila Janes, Sonja M. Best · 2025 · Viruses
  32. Evolution and expression of the duck TRIM gene repertoire
    Lee K. Campbell, Rhiannon M. Peery, Katharine E. Magor · 2023 · Frontiers in Immunology
  33. Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches
    P T Brindhavanam, Indrajit Sahu · 2024 · Biochemical Society Transactions
  34. Characterization of progression-related alternative splicing events in testicular germ cell tumors
    Chuanjie Zhang, Zongtai Li, Kan-Jie Shen, Lu Chen, Danfeng Xu, Yi Gao · 2020 · Asian Journal of Andrology
  35. Method for the Purification of Endogenous Unanchored Polyubiquitin Chains
    Daniel Scott, Joanna Strachan, Varun Gopala Krishna, Barry Shaw, David Tooth, Mark S. Searle, Neil J. Oldham, Robert Layfield · 2016 · Methods in molecular biology
  36. Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity
    Selver Altin, Tânia Simões, Christina Behrendt, Vincent Anton, Dennis Domke, Kai Voeltzke, Rajesh Kumar, Hendrik Nolte, Thomas Hermanns, Nahal Brocke‐Ahmadinejad et al. · 2025 · Molecular Cell
  37. Ubiquitination in viral entry and replication: Mechanisms and implications
    Maria I Velez Brochero, Padmanava Behera, Kazi Sabrina Afreen, Abby E. Odle, Ricardo Rajsbaum · 2024 · Advances in virus research
  38. Linear poly-ubiquitin remodels the proteome and influences hundreds of regulators in Drosophila
    Oluwademilade Nuga, Kristin Richardson, Nikhil C. Patel, Xusheng Wang, Vishwajeeth Pagala, Anna Stephan, Junmin Peng, Fabio Demontis, Sokol V. Todi · 2024 · G3 Genes Genomes Genetics
  39. An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein
    Tomoki Sorada, Erik Walinda, Masahiro Shirakawa, Kenji Sugase, Daichi Morimoto · 2023 · Protein Science
  40. Intracellular osteopontin potentiates the immunosuppressive activity of mesenchymal stromal cells
    Wanlin Yang, Min Jin, Yuting Gu, Xiaonan Zhao, Lingqiao Zhu, Shan He, Hui Wang, Xinyuan Ding, Bei Wang, Tingwang Jiang et al. · 2024 · Stem Cell Research & Therapy
  41. Nipah Virus: Through a Pandemic Lens
    Purva Salvi, Salonee Martins, Shalini Das, Mahalakshmi Bhat, Aishwarya Pathare · 2024 · Springer eBooks
  42. A tripartite motif protein (CgTRIM1) involved in CgIFNLP mediated antiviral immunity in the Pacific oyster Crassostrea gigas
    Jihan Wang, Xue Qiao, Zhaoqun Liu, Yuting Wang, Yuanmei Li, Yage Liang, Chang Liu, Lingling Wang, Linsheng Song · 2021 · Developmental & Comparative Immunology
  43. Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity
    Adolfo García‐Sastre, Lisa Miorin · 2016 · Elsevier eBooks
  44. KSHV hijacks the antiviral kinase IKKε to initiate lytic replication
    Xiaoqian Wang, Zhenshan Liu, Xue Xu, Xin Wang, Zizhen Ming, Chengrong Liu, Hang Gao, Tingting Li, Qiming Liang · 2025 · PLoS Pathogens
  45. Diacetyl-induced bronchiolitis obliterans involves ubiquitin C upregulation and fibrosis-related gene activation in rats
    Hailian Wang, Wen Jiang, Junchao Xiao, Yan Geng, Qing Ye, Wei Ge · 2025 · Frontiers in Pharmacology
  46. TRIM37 promotes antibacterial defense by regulating antimicrobial peptides in Chinese mitten crab (Eriocheir sinensis)
    Long-teng Shen, Miao Zhang, Zi-Yi Chen, Zhicheng Wan · 2026 · Fish & Shellfish Immunology
  47. Keratin 6a attenuates Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by suppressing ELKS/IKKε-dependent activation of NF-κB
    Jonathan Chan, Yan Sun, Anand Bhushan, Belinda B. Willard, Connie K. P. Tam · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  48. A proof‐of‐concept study in engineering synthetic protein for selective recognition of substrate‐free polyubiquitin
    Yehui Xiong, Lirong Zeng, Wende Liu · 2016 · PROTEOMICS
  49. Assays to Measure Suppression of Type I Interferon Responses by Filovirus VP35 Proteins
    Priya Luthra, Christopher F. Basler · 2017 · Methods in molecular biology
  50. Present and Future Opportunities in Imaging the Ubiquitin System (Ub-System)
    Leonardo Mortati, Barbara Pergolizzi, Cristina Panuzzo, Enrico Bracco · 2022 · Biophysica
  51. The Molecular and Function Characterization of Porcine MID2
    Jing Chen, Likun Zhou, Zhuosong Yang, Shijie Zhao, Wen Li, Yina Zhang, Pingan Xia · 2023 · Animals
  52. Cyclization of ubiquitin chains reinforces their recognition by ZNF 216
    Tomoki Sorada, Erik Walinda, Daichi Morimoto · 2024 · FEBS Letters
  53. Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1
    Duomeng Yang, Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison, Evelyn Teran, Yanlin Wang, Yanlin Wang, Anthony T. Vella et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Unanchored Ubiquitin Chains Promote the Non-Canonical Inflammasome via UBXN1
    Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison, Evelyn Teran, Yanlin Wang, Anthony T. Vella, Vijay A. K. Rathinam, Jianbin Ruan et al. · 2024 · SSRN Electronic Journal
  55. Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity
    Adolfo García‐Sastre, Lisa Miorin · 2025 · Elsevier eBooks
  56. RND3 restricts encephalomyocarditis virus replication by promoting IKKε ubiquitination and type I interferon production
    Peng Ma, Zheng Wang, Zhenhui Liu, Qi Xie, Tianxu Liu, Linjie Li · 2025 · Microbiology Spectrum
  57. The Role of Posttranslational Modifications During Ebola Virus Infection
    Joaquín Moreno-Contreras, Yoatzin Peñaflor-Téllez, Ricardo Rajsbaum · 2025 · Viruses
  58. Additional file 2 of Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms
    Miroslava Ondičová, Rachelle E Irwin, Thursby, Sara-Jayne, L Hilman, Aoife Caffrey, Cassidy, Tony, McLaughlin, Marian, Diane J. Lees‐Murdock, Ward, Mary, Michelle Murphy et al. · 2022 · Figshare
  59. Unanchored K63-linked polyubiquitin chains: a novel second messenger involved in G protein-coupled receptors early signaling events
    Priscilla Doyon, Daniel El-Mortada, Jiunn Roy, Firas El-Mortada, Florence Dô, Simon‐Pierre Gravel, Marc J. Servant · 2026 · Cell Communication and Signaling
  60. Caractérisation des processus d'ubiquitination régulant le facteur de transcription NF-kappaB au cours de l’activation lymphocytaire Rôle de l’E3 ligase TRIM13 et de la déubiquitinase USP34
    Emeline M. Hatchi · 2014 · theses.fr (ABES)
  61. Updates on the role of TRIM proteins in AIDS: molecular mechanisms and potential for interventions
    Jingxian Chen, Siyu Chen, Yu Xu, Xinling Wang, Meixiu Jiang · 2026 · Frontiers in Immunology
  62. TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence
    Sreya Sherin Biju, Ravi Prakash Arya, Anismrita Lahon · 2026 · Immunologic Research
  63. Back on the ground: genome analysis of convergent flight loss in rails
    Julien Gaspar, Steven A. Trewick, Gillian C. Gibb · 2026 · Journal of Evolutionary Biology