Cited by 312T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesHematopoietic Stem Cell Transplantation

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Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

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Graef, Patricia, Buchholz, Veit R., Stemberger, Christian, Flossdorf, Michael, Henkel, Lynette, Schiemann, Matthias, Drexler, Ingo, Höfer, Thomas, Riddell, Stanley R., Busch, Dirk H.·2014·Immunity

DOI 10.1016/j.immuni.2014.05.018

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Abstract

Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However, data supporting this hypothesis are focused on the developmental potential of lymphocyte populations and are thus insufficient to establish the functional hallmarks of stemness. Here, we investigated self-renewal capacity and multipotency of individual memory lymphocytes by in vivo fate mapping of CD8(+) T cells and their descendants across three generations of serial single-cell adoptive transfer and infection-driven re-expansion. We found that immune responses derived from single naive T (Tn) cells, single primary, and single secondary central memory T (Tcm) cells reached similar size and phenotypic diversity, were subjected to comparable stochastic variation, and could ultimately reconstitute immunocompetence against an otherwise lethal infection with the bacterial pathogen Listeria monocytogenes. These observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell compartment and highlight the promising therapeutic potential of this immune cell subset.

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Authors: Graef, P., Buchholz, V. R., Stemberger, C., Flossdorf, M., Henkel, L., Schiemann, M., Drexler, I., Höfer, T., Riddell, S. R., & Busch, D. H.
Affiliations: Technical University of Munich (DE)
German Cancer Research Center (DE)
Helmholtz Munich (DE)
Düsseldorf University Hospital (DE)
University of Washington (US)
Corresponding author: Busch, Dirk H.
ORCID: Buchholz, Veit R.
Stemberger, Christian
Schiemann, Matthias
Drexler, Ingo
Höfer, Thomas
Riddell, Stanley R.
Busch, Dirk H.
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-07
Volume: 41
Issue: 1
Pages: 116-126
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.05.018
OpenAlex: W2138073407
Cited by: 311
References: 70
Citations by year: 2026: 16 · 2025: 18 · 2024: 15 · 2023: 26 · 2022: 28 · 2021: 27 · 2020: 37 · 2019: 24 · 2018: 25 · 2017: 23 · 2016: 35 · 2015: 27 · 2014: 10
FWCI: 14.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
mediaTUM (Technical University of Munich) (submittedVersion)
Site cant be reached (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: CD8+ central memory T cells, T cell stemness, immunological memory, self-renewal, multipotency, naive T cells, Listeria monocytogenes, L-selectin
MeSH terms: Animals, Cell Differentiation, Immunocompetence, Immunologic Memory, Listeriosis, Listeria monocytogenes, Lymphocyte Activation, Mice, Inbred C57BL, T-Lymphocyte Subsets, Immunotherapy, Adoptive, Mice, Knockout, CD8-Positive T-Lymphocytes, L-Selectin, Cell Lineage, Multipotent Stem Cells, Mice, Adult Stem Cells

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Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

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