The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells
Open accessAbstract
The β-galactoside-binding protein galectin-9 is critical in regulating the immune response, but the mechanism by which it functions remains unclear. We have demonstrated that galectin-9 is highly expressed by induced regulatory T cells (iTreg) and was crucial for the generation and function of iTreg cells but not natural regulatory T (nTreg) cells. Galectin-9 expression within iTreg cells was driven by the transcription factor Smad3, forming a feed-forward loop, which further promoted Foxp3 expression. Galectin-9 increased iTreg cell stability and function by directly binding to its receptor CD44, which formed a complex with transforming growth factor-β (TGF-β) receptor I (TGF-βRI), and activated Smad3. Galectin-9 signaling was further found to regulate iTreg cell induction by dominantly acting through the CNS1 region of Foxp3 locus. Our data suggest that exogenous galectin-9, in addition to being an effector molecule for Treg cells, acts synergistically with TGF-β to enforce iTreg cell differentiation and maintenance.
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Cited by
TIM3 comes of age as an inhibitory receptor
Wolf, Y., Anderson, A. C., & Kuchroo, V. K. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0224-6 · Cited by 959
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Metadata
- Authors
- Wu, C., Thalhamer, T., Franca, R. F., Xiao, S., Wang, C., Hotta, C., Zhu, C., Hirashima, M., Anderson, A. C., & Kuchroo, V. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 41
- Issue
- 2
- Pages
- 270-282
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2117156688
- Cited by
- 349
- References
- 68
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, C., Thalhamer, T., Franca, R. F., Xiao, S., Wang, C., Hotta, C., Zhu, C., Hirashima, M., Anderson, A. C., & Kuchroo, V. K. (2014). Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells. Immunity. https://doi.org/10.1016/j.immuni.2014.06.011
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