The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Cited by (866)

Items 601–700 of 866

1. Engineering an immune-integrated lung-on-a-chip to reveal TOX–RAGE axis–driven fibrosis and RAGE blockade as a therapeutic strategy
   Hyelim Kim, C. H. Park, Seong‐Eun Kim, Seong-Eun Kim, June Hong Ahn, Je Kyung Seong, Wonhwa Lee, Seung‐Woo Cho, Hong Nam Kim · 2025 · Nano Convergence
2. The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment
   Minji Lim, Sang-Eun Jung, Choong‐Hyun Koh, Hyungwoo Jeong, Y. -W. Moon, Hyungseok Seo · 2026 · OncoImmunology
3. The insect Toll pathway activates antibacterial immunity against the citrus Huanglongbing pathogen
   Yu Du, Mengle Sun, Yuqing Xiao, Jinhua Yang, Manman Hu, Qian Chen, You Li, Tàiyún Wèi · 2026 · Nature Communications
4. The phosphatase DUSP2 constrains lymphoid remodeling and immunotherapy response in lung squamous carcinoma
   Jinghui Wang, Xin Zhang, Yuhua Wu, Ruobin Zong, Mengfan Guo, Ling Yi, Lina Zhang, Chong Wang, Xiang Gao, Liang Shi et al. · 2026 · Molecular Therapy
5. Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity
   Ander de Blas, Massimo Andreatta, Asier Antoñana-Vildosola, Paloma Velasco-Beltrán, Leire Egia‐Mendikute, Borja Jiménez-Lasheras, Alexandre Bosch, Adrián Barreira-Manrique, Iker Oyenarte, So Young Lee et al. · 2026 · Cancer Research
6. Engineering of genetically encoded programmable calcium channel inhibitory binders
   Xiaoxuan Liu, Sher Ali, Tien-Hung Lan, Decheng Wang, Brendan McKee, Tatsuki Nonomura, Siyao Liu, Feng Zhao, Michael X. Zhu, Yun Huang et al. · 2026 · Nature Communications
7. T cell exhaustion landscapes and therapeutic modulation in cancer immunity
   Jhommara Bautista, Andrés López‐Cortés · 2026 · Frontiers in Cell and Developmental Biology
8. T-cell exhaustion in tumor immunology: mechanisms, heterogeneity, and therapeutic strategies
   Ruoxuan Wang, Yingjie Guo · 2026 · Frontiers in Immunology
9. Regulatory T Cells in Hepatocellular Carcinoma: Spatial Niches, Biomarkers, and Clinical Implications
   Dimitris Liapopoulos, Panagiotis Sarantis, Georgios Zogas, Eleni-Myrto Trifylli, Thaleia-Eleftheria Bousou, Konstantina Kamitaki, Ioanna A. Anastasiou, Stefania Kokkali, Sotiris Mavromatis, Evangelos Koustas et al. · 2026 · International Journal of Molecular Sciences
10. Mastering an exhausting marathon: how CD8+ T cells fine‐tune metabolic fitness
    Anna M. Schulz, Dietmar Zehn · 2022 · Immunology and Cell Biology
11. Unique Characteristics of Neonatal T Cells
    Linda Aimara Kempis-Calanis, Otoniel Rodríguez-Jorge, Carlos Jesús Ventura-Martínez, Darely Y. Gutiérrez‐Reyna, Salvatore Spicuglia, Marı́a Angélica Santana · 2023 · Medical Research Archives
12. Interplay between CD28 and PD-1 in T cell immunotherapy
    Zuhayr Jafri, Jingwen Zhang, Connor H. O’Meara, Anthony Michael Joshua, Christopher Richard Parish, Levon Michael Khachigian · 2024 · Vascular Pharmacology
13. The Single-Cell Level Perspective of the Tumor Microenvironment and Its Remodeling by CAR-T Cells
    Sanxing Gao, Ryohichi Sugimura · 2022 · Cancer treatment and research
14. Larval T Cells Are Functionally Distinct from Adult T Cells in Xenopus laevis
    Matthieu Paiola, Connor C. McGuire, Vania Lopez Ruiz, Francisco De Jesús Andino, Jacques Robert · 2023 · ImmunoHorizons
15. Neoantigen Cancer Vaccines and Different Immune Checkpoint Therapies Each Utilize Both Converging and Distinct Mechanisms that in Combination Enable Synergistic Therapeutic Efficacy
    Sunita Keshari, Alexander S. Shavkunov, Qi Miao, Akata Saha, Charmelle D. Williams, Anna M. Highsmith, Josue Estiven Pineda, Elise Alspach, Kenneth H. Hu, Kristen E. Pauken et al. · 2024 · SSRN Electronic Journal
16. Transcription factor collaboration enables precise T cell state engineering
    Rachel E. Savage, Christian D. McRoberts Amador, Conrad Hock, Ruochi Zhang, Hung‐Che Kuo, Aretha Gao, Max A. Horlbeck, Charles A. Gersbach, Jason D. Buenrostro · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
17. The frequency of peripheral PD-1+ TCD4+ cells is reversely associated with serum creatinine levels in recipients of kidney allografts
    Alireza Mardomi, Maryam KarajiBani, Farahnoosh Farnood, Sepideh Zununi Vahed, Mohammadreza Ardalan · 2023 · Transplant Immunology
18. Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance
    David A.J. Lecky, Lozan Sheriff, Sophie Rouvray, L. George, Alastair Copland, Rebecca A. Drummond, David Cameron Wraith, David Bending · 2025 · iScience
19. From ex vivo to in vitro models: towards a novel approach to investigate the efficacy of immunotherapies on exhausted Vγ9Vδ2 T cells?
    Morgane Chauvet, Dorothée Bourges, Emmanuel Scotet · 2025 · Frontiers in Immunology
20. Development of therapeutic cancer vaccines based on cancer immunity cycle
    Jing Zhang, Yiyuan Zheng, Lili Xu, Jing Gao, Zhuoyu Ou, Mingzhao Zhu, Wenjun Wang · 2025 · Frontiers of Medicine
21. Immune cell transcriptional profiles from pre-vaccination peripheral blood predict immune response to preventative MUC1 cancer vaccine
    Daniel Y. Yuan, Michelle L. McKeague, Vineet K. Raghu, Robert E. Schoen, Olivera J. Finn, Panayiotis V. Benos · 2025 · European Journal of Cancer
22. Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion
    Parisa Samareh, Paula A. Agudelo-Garcia, Zhen Zhang, Michael B. Gilbert, Mariel R. Mendoza, Hua Huang, Jennifer E. Wu, Amy E. Baxter, Zeyu Chen, Kate Alexander et al. · 2025 · The Journal of Immunology
23. Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression
    Marc A. D’Antonio, Brian C. Ware, James E. DiLisio, Mary Jessamine Michaels, Jacqueline A. Turner, Lauren M Habenicht, Bennett Davenport, Thomas E. Morrison, Roberta Pelanda, Laurent Gapin et al. · 2025 · The Journal of Immunology
24. Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells
    Joshua Flynn, Anne‐Marie Baird, Eamon P. Breen, Michael Carty, Ciara S. McNevin, Lisa McDermott, Elaine M. Kenny, John Davis Coakley, Thomas Ryan, Derek G. Doherty et al. · 2025 · Frontiers in Immunology
25. Differential Regulation of TCR‐Induced ZFP36 and ZFP36L1 Expression by Cyclosporin A in CD8 + T Cells
    Marian Jones Evans, Twm J. Mitchell, Magdalena Zaucha, Georg Petkau, Martin Turner · 2025 · European Journal of Immunology
26. HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells
    Di Liu, Jiang-bo Fan, Rui Wang, You Li, Wan-da Bi, Si-yuan Huang, Heng-hai Nie, Xi-feng Feng, Hua-Cai Zhang, Juan Du et al. · 2026 · JCI Insight
27. DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling
    Xinran Ma, Yu Zhang, Yao Wang, Fuxin Han, Yuting Lu, Chuan Tong, Yelei Guo, Jianshu Wei, Qi Zhu, Liang Dong et al. · 2026 · Signal Transduction and Targeted Therapy
28. Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
    Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang · 2026 · Advanced Science
29. Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer’s pathogenesis
    Li Yang, Jianting Sheng, Shaohua Qi, Zheng Yin, Michael Chan, Yuliang Cao, Hong Zhao, Zhihao Wan, Bill Chan, Ju Young Ahn et al. · 2026 · Molecular Neurodegeneration
30. Single-cell RNA sequencing unravels T cell exhaustion underlying the chronicity of chromoblastomycosis
    Kexin Lei, Jie Tian, Lu Zhang, Zhuoqing Gong, Wenjie Liu, Zhe Wan, Yang Wang, Ruoyu Li, Bilin Dong, Xiaowen Wang · 2026 · Frontiers in Immunology
31. T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
    Suqing Zhou, Lian Jian, Hui Chen, Huan Yin, Fanghan Ji, Ming Yang, Haijing Wu · 2026 · Clinical Reviews in Allergy & Immunology
32. Immune checkpoint crosstalk between LAG-3 and CD39/CD73 in glioblastoma: dual-pathway regulation of metabolic exhaustion and therapeutic reversal strategies
    Dr. Arpita Mukherjee · 2026 · Journal of the Egyptian National Cancer Institute
33. The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells
    Marco Ongaro, Romane Thouenon, Isaac Crespo, Alexandre Dumez, Mélanie Charmoy, Eduardo Roman Camacho, Victoria J. Morel, Daniela Cropp, Emma Desponds, Giulio Zanette et al. · 2026 · The Journal of Experimental Medicine
34. T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy
    Lauren van den Broecke, Arne Van der Vreken, Fenja Watté, Fien Meeus, Kim De Veirman, Karine Breckpot, Elke De Bruyne, Eline Menu · 2026 · Signal Transduction and Targeted Therapy
35. Intermittent administration of tacrolimus enhances anti-tumor immunity in melanoma-bearing mice
    Ting Chen, Qi Zhang, Nianhai Zhang, Bo Liu, Junying Chen, Fei Huang, Jianhua Lin, Ruilong Lan, Xianhe Xie, Zili Wang · 2022 · Carcinogenesis
36. Individual Epitope-Specific CD8+ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection
    Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R.M. Kraft · 2023 · Pathogens
37. Machine learning reveals genetic modifiers of the immune microenvironment of cancer
    Bridget M. Riley-Gillis, Shirng‐Wern Tsaih, Emily A. King, Sabrina Wollenhaupt, Jonas Reeb, Amy R. Peck, Kelsey K. Wackman, Angela Lemke, Hallgeir Rui, Zoltán Dezső et al. · 2023 · iScience
38. The road not taken en route to T cell exhaustion
    Barsha Dash, Patrick G. Hogan · 2023 · Nature Immunology
39. Cancer- and infection-induced T cell exhaustion are distinct
    Jessica Buck, Nikhil S. Joshi · 2023 · Nature Immunology
40. Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx
    Ragini Vittal, Natalie Walker, A. Patrick McLinden, Russell R. Braeuer, Fang Ke, Fatemeh Fattahi, Michael P. Combs, Keizo Misumi, Yoshiro Aoki, David Wheeler et al. · 2023 · American Journal of Physiology-Lung Cellular and Molecular Physiology
41. Construction and validation of prognostic signature for transcription factors regulating T cell exhaustion in hepatocellular carcinoma
    Xi Jin, Kun Zhou, Rongzheng Zhang, Jingbo Li, Mengrui Guo, Han Qiao, Meng Wu, Xinyang Cao, Guanglu Dong, Shuyun Zhang · 2024 · Medicine
42. MALINC1 an Immune-Related Long Non-Coding RNA Associated with Early-Stage Breast Cancer Progression
    María Laura Fabre, Romina Canzoneri, Agustina Gurruchaga, Jae‐Ho Lee, Pradeep Tatineni, Hyunsuk Kil, Ezequiel Lacunza, C. Marcelo Aldaz, Martı́n C. Abba · 2022 · Cancers
43. Immune Cell Metabolic Fitness for Life
    Kevin S. Bittman · 2022 · Antibodies
44. Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity
    Andrew R. DiNardo, Kimal Rajapakshe, Tomoki Nishiguchi, Godwin Mtetwa, Qiniso Dlamini, Jaqueline Kahari, Sanjana Mahapatra, Alexander W. Kay, Gugu P. Maphalala, Emily Margaret Mace et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
45. Three-dimensional genome structure and chromatin accessibility reorganization during in vivo induction of human T cell tolerance
    Ruifeng Li, Huidong Guo, Yingping Hou, Shuoshuo Liu, Ming Wang, Ting Peng, Xiang‐Yu Zhao, Liming Lu, Yali Han, Yiming Shao et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
46. In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer
    Zeyu Chen, Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan Ming He, Hua Huang, Sasikanth Manne, Zhendong Cao, Amy E. Baxter et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
47. NFAT Transcription Factors are Essential and Redundant Actors for Leukemia Initiating Potential in T-cell Acute Lymphoblastic Leukemia
    Claire Catherinet, Diana Passaro, Stéphanie Gachet, Hind Medyouf, Anne Reynaud-Angelin, Charlène Lasgi, Jacques Ghysdael, Christine Tran Quang · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
48. Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy
    Erica Dhuey, Olivia Oldridge, Roshan Ravishankar, Hannah Dada, Yongjun Yu, Mark Stuart Anderson, Andy J. Minn · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
49. T cell Egress via Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma
    Maria M. Steele, Ian D. Dryg, Dhaarini Murugan, Julia Femel, Haley du Bois, Cameron M. Hill, Sancy Ann Leachman, Young Hwan Chang, Lisa M. Coussens, Amanda W. Lund · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
50. Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling
    Jian Tang, Xian Jia, Taoling Zeng, Yuzhou Bao, Yanyan Hu, Junchen Dong, Xiaozheng Xu, Xiao Lei Chen, Yongchao Liu, Jiayu Wang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
51. Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradation
    Erik Ehinger, Kristy C. Perez, Emi Sanchez, Bruno Villalobos Reveles, Barsha Dash, Leo J. Arteaga-Vazquez, Eric Johnson, Anjana Rao, Patrick G. Hogan · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
52. The Functional Adaptability of Hyporesponsive T Cells and Its Impact on Transplant Outcomes
    Dawei Zou, Xiaolong Zhang, Wenhao Chen · 2023 · Current Transplantation Reports
53. Selenium affects genes associated with immunity and apoptosis in in vitro follicles of ewes
    Leonor Miranda Jiménez, María Monserrat López-Velázquez, Adrián Raymundo Quero-Carrillo, Alejandrina Robledo-Paz · 2024 · Austral journal of veterinary sciences
54. Immune suppression sustained allograft acceptance requires PD1 inhibition of CD8+ T cells
    Hilary Miller‐Handley, Gavin Harper, Giang H. Pham, Lucien H. Turner, Tzu‐Yu Shao, Abigail E. Russi, John J. Erickson, Mandy L. Ford, Koichi Araki, Sing Sing Way · 2025 · The Journal of Immunology
55. NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection
    Nadine Hundhausen, Snigdha Majumder, Yin Xiao, Sigrun S. Haeusl, Helen Goehler, Rishav Seal, Cristina Maria Chiarolla, Andreas Rosenwald, Matthias K. Eyrich, Luka Čičin‐Šain et al. · 2025 · iScience
56. MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion
    Tanya Mitra, Jahan A. Rahman, Madeline A. Hwee, Yan-Ting Chen, Ruben Jose Jesus Faustino Ramos, Hui Liu, Travis E. Hartman, Justin R. Cross, Miguel de Jesus, Morgan Huse et al. · 2026 · Immunity
57. Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice
    Damien Freytag, Stéphane Giorgiutti, Grégoire Hopsomer, Nadège Wadier, Sabine Depauw, Philippe Mertz, Fabrice Augé, Raphaël Carapito, Isabelle Couillin, Anne‐Sophie Korganow et al. · 2025 · EMBO Molecular Medicine
58. Mapping Current Research Status and Emerging Frontiers of T-Cell Exhaustion: A Comprehensive Data-Mining-Based Study
    Pengcheng Li, Qiang Guo, Yanfeng Gao, Wanqing Li, Haiyang Wu · 2025 · Annals of Surgical Oncology
59. Dual-action PD-L1 depletion in tumor cells and macrophages revitalizes immune attack in hepatocellular carcinoma
    Xu Gao, Enrui Xie, Yue Zhang, Xindi Huang, Taotao Huo, Xinyuan He, Zixuan Xing, Fang Ma, Yujiao Deng, Chenyang Qiao et al. · 2025 · Chemical Engineering Journal
60. Attention-Guided Probabilistic Diffusion Model for Generating Cell-Type-Specific Gene Regulatory Networks from Gene Expression Profiles
    Shiyu Xu, Na Yu, Daoliang Zhang, Chuanyuan Wang · 2025 · Genes
61. JNK knockdown enhances CAR-T cell cytotoxicity through elevated NFATc1-dependent transcription in preclinical ovarian cancer models
    Charles J. Kuhlmann, Chloe E Jepson, Madison T Blucas, Fatema M Suleiman, Anusha Manda, Yoshiko N Kamata, Masakazu Kamata · 2025 · Journal for ImmunoTherapy of Cancer
62. Tempered signal strength via low-dose MEK inhibition optimizes therapeutic performance of engineered T cells
    Franziska Füchsl, Antonia Schwanzer, Melanie Faber, Leonie Rieger, Gabriela Zuleger, Priska Auf der Maur, Emmanuel Cruz, Sarah Braun, Rupert Öllinger, Dirk Hans Busch et al. · 2025 · Journal for ImmunoTherapy of Cancer
63. TLR7-mediated inflammation drives PD-L1 upregulation and T cell exhaustion during influenza A virus infection
    Mark A. Miles, Stella Liong, Felicia Liong, John J. O’Leary, Doug A. Brooks, Stavros Selemidis · 2026 · iScience
64. Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion
    Mélanie Charmoy, Julia Maier, Tania Wyss, Vijaykumar Chennupati, Catherine M. Sabatel, Laurie Bonneaux, Alexandre Dumez, Romain Veber, Greta Guarda, Werner Held · 2026 · Frontiers in Immunology
65. One cell, many fates: transcriptional networks governing CD8 + T cell differentiation
    M. Zeeshan Chaudhry, Gabrielle Therese Belz · 2026 · Immunology and Cell Biology
66. Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation
    Matthias Reinscheid, J Weißer, N Pascual Maier, David B. Reeg, P L Hafkemeyer, Lara Kelsch, Giuseppe Rusignuolo, Jakob Arnold, Florian Emmerich, Andreas Walker et al. · 2026 · Immunity
67. EZH2 and intracellular Ca2+ signals interdependently coordinate alloreactive and CAR-T-cell responses
    Ying Wang, Qingrong Huang, Yan Zhou, Robert Hooper, Ruqayyah sanders-Braggs, Mimi Chen, Yuanyuan Tian, Tatiana Kent, Richard T. Pomerantz, Gennaro Clando et al. · 2026 · Cellular and Molecular Immunology
68. iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk
    Jianting Sheng, Ju Young Ahn, Li Yang, Zhihao Wan, Shaohua Qi, Xiaohui Yu, Zhan Xu, Yuliang Cao, Matthew Vasquez, Amna Irfan et al. · 2026 · Signal Transduction and Targeted Therapy
69. T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions
    Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Z Wang, Zhixian Zhong, Yi Zhong · 2026 · Advanced Science
70. Two Faces of NFAT Transcription Factors in Lymphocytes—A Personal Account
    Edgar Serfling · 2026 · Biomolecules
71. Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity
    Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng · 2026 · The Journal of Experimental Medicine
72. Enhancing persistence while managing cytokine release syndrome to embrace next-generation CAR-T cell therapy
    Yulin Yang, Yuanjie Sun, Haobo Kang, Enqi Guan, Rui Liu, Kun Yang, Dongbo Jiang · 2026 · Journal of Translational Medicine
73. Systematic optimization of PD-L1 and CLDN18.2 CAR-T designs identifies a bicistronic dual-target, double-CD3ζ architecture with enhanced antitumor activity in gastric cancer
    Xiang Zhang, Yao-jie Kong, Jingyao Li, Heng-hui Li, Liang Chen · 2026 · Frontiers in Immunology
74. Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function
    Oliver Takacsi-Nagy, Sivakanthan Kasinathan, Austin Hartman, Yajie Yin, Lujing Wu, Andy Y. Chen, Laura M. Moser, Audre May, Gabriella C. Reeder, Emily Celallos Fuentes et al. · 2026 · Cell
75. CAR signaling instructs divergent metabolic reprogramming and functional fates in αβ and γδ T cells
    Xiomar E. Bustos, L. Tordesillas, Elena Martinez-Planes, Miguel G. Fontela, Sebastian A. Snedal, R. Rossetti, V. Izumi, Bin Fang, John M. Koomen, Eric A. Welsh et al. · 2026 · Cellular & Molecular Immunology
76. Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma cells
    Krisna Murti, Hendrik Eike Fender, Carolin Glatzle, Rhoda Wismer, Salvador Sampere-Birlanga, Vanessa Wild, Khalid Muhammad, Andreas Rosenwald, Edgar Serfling, Andris Avots · 2023 · Frontiers in Oncology
77. The Characteristics of Transcription Factors Regulating T Cell Exhaustion Were Analyzed to Predict the Prognosis and Therapeutic Effect in Patients with HCC
    Jingbo Li, Kun Zhou, Meng Chao Wu, Rongzheng Zhang, Xi Jin, Han Qiao, Jiaqi Li, Xinyang Cao, Shuyun Zhang, Guanglu Dong · 2023 · International Journal of General Medicine
78. Combining antigen-specific T cells with T-cell engager therapy induces a molecular signature that favors T-cell fitness
    Manpreet Bariana, Sidharth R. Anand, Mark Batistick, Elena Cassella, Shaina A. Anuncio, Ariel Alejandro Aptekmann, David Samuel DiCapua Siegel, Mathias Oelke, Sojung Kim, Ruipeng Wang et al. · 2025 · Blood Immunology & Cellular Therapy
79. Distinct immune properties of the N- and C-termini of the immunosuppressive domain of Ebola virus glycoprotein
    Mathieu Iampietro, Sivakumar Periasamy, Philipp A. Ilinykh, Yuan Qiu, Yakun Liu, Abhinit Nagar, Bin Gong, Alexander A. Bukreyev · 2025 · mBio
80. SRC-3/AIB-1 may Enhance Hepatic NFATC1 Transcription and Mediate Inflammation in a Tissue-Specific Manner in Morbid Obesity
    Athina Chasapi, Konstantinos Balampanis, Anna Tanoglidi, Eleni P. Kourea, George Ι. Lambrou, Vaia Lambadiari, Fotios Kalfarentzos, Erifili E. Hatziagelaki, Maria Melachrinou, Georgia Sotiropoulou‐Bonikou · 2019 · Endocrine Metabolic & Immune Disorders - Drug Targets
81. Challenges and Opportunities to Improve CAR T-Cell Therapy
    Mumtaz Yaseen Balkhi · 2019 · Elsevier eBooks
82. Scientific divagations: from signaling and transcription to chromatin changes in T cells
    Anjana Rao · 2020 · Nature Immunology
83. The Morphofunctional Response of T-lymphocytes to in vitro Contact with a Calcium Phosphate Coating in the Presence of a T-cell Activator
    Larisa Sergeevna Litvinova, Е. С. Мелащенко, Хазиахматова Ольга Геннадьевна, Kristina Alekseevna Yurova, Yu. P. Sharkeev, Комарова Екатерина Геннадьевна, Мария Борисовна Седельникова, Н. М. Тодосенко, И. А. Хлусов · 2021 · Cell and Tissue Biology
84. Orthogonal Gene Engineering Enables CD8 + T Cells to Control Tumors through a Novel PD-1 + TOX-indifferent Synthetic Effector State
    Jesús Corría-Osorio, Santiago J. Carmona, Evangelos Stefanidis, Massimo Andreatta, Tania Muller, Yaquelin Ortiz-Miranda, Bili Seijo, Wilson Castro, Cristina Jiménez‐Luna, Léonardo Scarpellino et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
85. NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8 + T cells
    M. Zeeshan Chaudhry, Lisa Borkner, Friederike Berberich‐Siebelt, Luka Čičin‐Šain · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
86. T cell polarization and NFAT translocation are stiffness-dependent and are differentially regulated by Piezo1 and Orai1
    Renping Zhao, Jingnan Zhang, Eva C. Schwarz, Aránzazu del Campo, Markus Hoth, Bin Qu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
87. IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection
    Yaping Chen, Pengcheng Zhou, Patrick M. Gubser, Yew Ann Leong, Jing He, Yunbo Wei, Fadzai Victor Makota, Mehrdad Pazhouhandeh, Ting Zheng, Joseph Yunis et al. · 2024 · eLife
88. FOS+ Macrophages Promote Chronic Rejection of Cardiac Transplantation.
    Shi Chen, Yi Wang, Huisheng Zhou, Hongmei Jiang, Peixiang Lan, Zhishui Chen · 2024 · Experimental and Clinical Transplantation
89. Different signaling interpretations by PKC eta and theta control T cell function and exhaustion
    Thomas H. Mann, Hannah M. Knox, Shixin Ma, Jesse Furgiuele, Anna-Maria Globig, Michael A. LaPorta, H. Kay Chung, Bryan McDonald, Majid Ghassemian, Steven Zhao et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
90. Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancer
    Han Zhang, Binfeng Lu, Aodong Qiu, Gregory F. Cooper, Anwaar Saeed, John William Paisley, Xinghua Lu, Lujia Chen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
91. Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1 + Tcf1 + stem-like reservoir and overcomes resistance to PD-1 axis blockade
    Andrew J. Snyder, Carolyn Shasha, Tam Ho, Sarah M. Garrison, Amelia R. Wilhelm, Mitchell G. Kluesner, Sergio Ortiz, W. Sam Nutt, Emma Bingham, Shruti S. Bhise et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
92. Single-cell multi-omics reveals archetypal regulatory programs shared across T cell subsets
    Sarah K. Walker, Joris van der Veeken, Alexander Yu Rudensky, Yuri Pritykin · 2026 · Cell Reports
93. Cysteine reactivity profiling links metabolic rewiring to the dysfunctional human T cell proteome
    Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson, Henry Sanford, Tzu-Jou Chen, Ya-Hui Lin, Joshua David Schoenfeld, Lisa H.F. McGary, Yanting Chen, Korbinian Nepomuk Kropp et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
94. Theranostic Approaches for Pathway-Activated Systems in Oncology
    Lan V. Pham, Jerry L. Bryant, David J. Yang, Richard J Ford · 2017 · Springer eBooks
95. Transgenic expression of proinsulin to inactivate insulin-specific CD8+ T-cell responses in autoimmune diabetes
    Peta Reeves · 2016 · The University of Queensland
96. Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia
    Saeid Taghiloo, Esmaeil Allahmoradi, Mohsen Tehrani, Ghasem Janbabaei, Ramin Shekarriz, Hossein Asgarian‐Omran · 2017 · Research in Molecular Medicine
97. Tolerogenic transcriptome landscape in CD8+ T lymphocytes after exposure to erythrocyte-targeted antigens
    Alizée J Grimm, Cédric Gobet, Giacomo Diaceri, Xavier Quaglia-Thermes, Jeffrey A. Hubbell · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
98. TGF-BETA1/SMAD3 SUPPRESS ANTI-TUMOR IMMUNITY BY ENHANCING PD-1 EXPRESSION ON ANTIGEN-SPECIFIC CD8+ T CELLS IN CANCER
    Benjamin Vincent Park · 2015
99. Immunization With Recombinant Myelin Oligodendrocyte Glycoprotein Identifies Autoreactive T Cells As A Limiting Factor In Autoreactive Germinal Center Maintenance
    Rajiv W. Jain · 2018 · Scholarship@Western (Western University)
100. TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells
     James M. Conley · 2019 · eScholarship@UMassChan