The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
Martinez, Gustavo J., Pereira, Renata M., Äijö, Tarmo, Kim, Edward Y., Marangoni, Francesco, Pipkin, Matthew E., Togher, Susan, Heissmeyer, Vigo, Zhang, Yi Chen, Crotty, Shane, Lamperti, Edward D., Ansel, K. Mark, Mempel, Thorsten R., Lähdesmäki, Harri, Hogan, Patrick G., Rao, Anjana·2015·Immunity
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- Cellular and molecular mechanisms of CD8(+) T cell differentiation, dysfunction and exhaustionVerdon, Daniel J., Mulazzani, Matthias, Jenkins, Misty R. · 2020 · International Journal of Molecular Sciences
- Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155Erietta Stelekati, Zeyu Chen, Sasikanth Manne, Makoto Kurachi, Mohammed-Alkhatim Ali, Keith Lewy, Zhangying Cai, Kito Nzingha, Laura M. McLane, Jennifer L. Hope et al. · 2018 · Cell Reports
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- Newtonian cell interactions shape natural killer cell educationJodie P. Goodridge, Björn Önfelt, Karl‐Johan Malmberg · 2015 · Immunological Reviews
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- PD-1 expression conditions T cell avidity within an antigen-specific repertoireSylvain Simon, Virginie Vignard, Laëtitia Florenceau, Brigitte Dréno, Amir Khammari, François Lang, Nathalie Labarrière · 2015 · OncoImmunology