The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair
Open accessAbstract
Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens and infectious agents and play critical roles in resistance and tolerance associated with infection, wound healing, tissue repair and tumor development. Emerging data suggest that in addition to characteristic type 2-associated cytokines, the Epidermal Growth Factor (EGF)-like molecule Amphiregulin (AREG) may be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that in addition to the established role of epithelial- and mesenchymal-derived AREG, multiple leukocyte populations including mast cells, basophils, group 2 innate lymphoid cells (ILC2) and a subset of tissue-resident regulatory CD4+ T cells can express AREG. In this review, we discuss recent advances in our understanding of the AREG-EGF receptor pathway and its involvement in infection and inflammation, and propose a model for the function of this pathway in the context of resistance and tissue tolerance.
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Cites
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Inflammatory cells during wound repair: the good, the bad and the ugly
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“Successful wound repair requires efficient resolution of local inflammation (Martin and Leibovich, 2005) as dysregulation of pathogen-elicited immune responses carries the risk of inducing collateral tissue damage.”
BackgroundInnate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234
Differential Roles of Macrophages in Diverse Phases of Skin Repair
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ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
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“While EGFR signaling mechanisms have been reviewed comprehensively elsewhere (Arteaga and Engelman, 2014; Avraham and Yarden, 2011), how AREG might mediate differential effects of EGFR signaling to promote tissue homeostasis is a key area of investigation.”
BackgroundSutmuller, R. P. M., van Duivenvoorde, L. M., van Elsas, A., Schumacher, T. N. M., Wildenberg, M. E., Allison, J. P., Toes, R. E. M., Offringa, R., & Melief, C. J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.823 · Cited by 1,008
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Mast cells are essential intermediaries in regulatory T-cell tolerance
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Cited by
A Distinct Function of Regulatory T Cells in Tissue Protection
Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991
Barrier Epithelial Cells and the Control of Type 2 Immunity
Hammad, H., & Lambrecht, B. N. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.007 · Cited by 847
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., et al. (2019) · Nature · doi:10.1038/s41586-018-0824-5 · Cited by 784
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Tissue-specific contribution of macrophages to wound healing
Minutti, C. M., Knipper, J. A., Allen, J. E., & Zaiss, D. M. W. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2016.08.006 · Cited by 470
Self-citation
Metadata
- Authors
- Zaiss, D. M. W., Gause, W. C., Osborne, L. C., & Artis, D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 42
- Issue
- 2
- Pages
- 216-226
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2076327296
- Cited by
- 638
- References
- 16
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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