Epidermal fatty acid binding protein promotes skin inflammation induced by high-fat diet
Open accessAbstract
Defining specific cellular and molecular mechanisms in most obesity-related diseases remains an important challenge. Here we report a serendipitous finding that consumption of a high-fat diet (HFD) greatly increased the occurrence of skin lesions in C57BL/6 mice. We demonstrated that HFD induced the accumulation of a specific type of CD11c(+) macrophages in skin preceding detectable lesions. These cells primed skin to induce IL-1β and IL-18 signaling, which further promoted the cytokines IFN-γ- and IL-17-mediated skin inflammation. Mechanistically, epidermal fatty acid binding protein (E-FABP) was significantly upregulated in skin of obese mice, which coupled lipid droplet formation and NLRP3 inflammasome activation. Deficiency of E-FABP in obese mice decreased recruitment of CD11c(+) macrophages in skin tissues, reduced production of IL-1β and IL-18, and consequently dampened activation of effector T cells. Furthermore, E-FABP-deficient mice are completely resistant to HFD-induced skin lesions. Collectively, E-FABP represents a molecular sensor triggering HFD-induced skin inflammation.
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The effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.
“In general, the effect of a high-fat diet is mainly to cause aging of the skin by causing skin oxidative stress to produce inflammatory damage.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [92]
After high-fat diet, epidermal fatty acid-binding protein (E-FABP) of mice was significantly upregulated in the skin, which promoted formation of lipid droplets and activation of NLRP3 inflammasome, and greatly increased incidence of skin lesions in mice.
“Studies by Zhang and others [92] showed that after high-fat diet, the epidermal fatty acid-binding protein (E-FABP) of mice was significantly upregulated in the skin, which promoted the formation of lipid droplets and the activation of NLRP3 inflammator, and greatly increased the incidence of skin lesions in mice.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [92]
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References 52 · Cited by 137
Research works printed but not linked: 1
- Vandanmagsar B Youm YH Ravussin A Galgani JE Stadler K Mynatt RL Ravussin E Stephens JM Dixit VD The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med 2011b 17 179 188 21217695 PMC3076025
- Authors
- Zhang, Y., Li, Q., Rao, E., Sun, Y., Grossmann, M. E., Morris, R. J., Cleary, M. P., & Li, B.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Li, Bing
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 42
- Issue
- 5
- Pages
- 953-964
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4440244
- OpenAlex
- W1901439132
- Cited by
- 137
- References
- 52
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 16 · 2023: 12 · 2022: 10 · 2021: 14 · 2020: 12 · 2019: 12 · 2018: 14 · 2017: 12 · 2016: 6 · 2015: 3
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000135)
- National Cancer Institute (CA18098601A1, CA17767901A1, CA157012, R01CA177679, R01CA157012, R01CA180986)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, 5P30DK50456, U24DK100469)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- epidermal fatty acid binding protein, high-fat diet, skin inflammation, obesity, CD11c+ macrophages, NLRP3 inflammasome, IL-1β, IL-18, IL-17, interferon-gamma, lipid droplets, effector T cells, skin lesions
- MeSH terms
- Animals, Immunohistochemistry, Inflammation, Male, Mice, Inbred C57BL, Neoplasm Proteins, Skin Diseases, T-Lymphocytes, Cytokines, Mice, Knockout, Fatty Acid-Binding Proteins, Mice, Diet, High-Fat
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