The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells
Open accessAbstract
Summary Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs). Pathways that specifically allow LLPCs to persist remain unknown. Through bioenergetic profiling, we found that human and mouse LLPCs could robustly engage pyruvate-dependent respiration whereas their short-lived counterparts could not. LLPCs took up more glucose than did short-lived plasma cells (SLPCs) in vivo, and this glucose was essential for the generation of pyruvate. Glucose was primarily used to glycosylate antibodies, but glycolysis could be promoted by stimuli such as low ATP levels and the resultant pyruvate used for respiration by LLPCs. Deletion of Mpc2, which encodes an essential component of the mitochondrial pyruvate carrier, led to a progressive loss of LLPCs and of vaccine-specific antibodies in vivo. Thus, glucose uptake and mitochondrial pyruvate import prevent bioenergetic crises and allow LLPCs to persist. Immunizations which maximize these plasma cell metabolic properties may thus provide enduring antibody-mediated immunity.
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Metadata
- Authors
- Lam, W. Y., Becker, A. M., Kennerly, K. M., Wong, R., Curtis, J. D., Llufrio, E. M., McCommis, K. S., Fahrmann, J., Pizzato, H. A., Nunley, R. M., Lee, J., Wolfgang, M. J., Patti, G. J., Finck, B. N., Pearce, E. L., & Bhattacharya, D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 45
- Issue
- 1
- Pages
- 60-73
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2473268164
- Cited by
- 283
- References
- 65
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lam, W. Y., Becker, A. M., Kennerly, K. M., Wong, R., Curtis, J. D., Llufrio, E. M., McCommis, K. S., Fahrmann, J., Pizzato, H. A., Nunley, R. M., Lee, J., Wolfgang, M. J., Patti, G. J., Finck, B. N., Pearce, E. L., & Bhattacharya, D. (2016). Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity. https://doi.org/10.1016/j.immuni.2016.06.011
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