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Cited by 438Malaria Research and ControlT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

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Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

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Fernandez-Ruiz, Daniel, Ng, Wei Yi, Holz, Lauren E., Ma, Joel Z., Zaid, Ali, Wong, Yik Chun, Lau, Lei Shong, Mollard, Vanessa, Cozijnsen, Anton, Collins, Nicholas, Li, Jessica, Davey, Gayle M., Kato, Yu, Devi, Sapna, Skandari, Roghieh, Pauley, Michael, Manton, Jonathan H., Godfrey, Dale I., Braun, Asolina, Tay, Szun Szun, Tan, Peck Szee, Bowen, David G., Koch-Nolte, Friedrich, Rissiek, Björn, Carbone, Francis R., Crabb, Brendan S., Lahoud, Mireille, Cockburn, Ian A., Mueller, Scott N., Bertolino, Patrick, McFadden, Geoffrey I., Caminschi, Irina, Heath, William R.·2016·Immunity
DOI 10.1016/j.immuni.2016.08.011
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Abstract

In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably depend upon development of a broadly protective vaccine. To better understand immune requirement for protection, we examined liver-stage immunity after vaccination with irradiated sporozoites, an effective though logistically difficult vaccine. We identified a population of memory CD8+ T cells that expressed the gene signature of tissue-resident memory T (Trm) cells and remained permanently within the liver, where they patrolled the sinusoids. Exploring the requirements for liver Trm cell induction, we showed that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge. Our study highlights the immune potential of liver Trm cells and provides approaches for their selective transfer, expansion, or depletion, which may be harnessed to control liver infections or autoimmunity.

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Metadata

Authors
Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., Li, J., Davey, G. M., Kato, Y., Devi, S., Skandari, R., Pauley, M., Manton, J. H., Godfrey, D. I., Braun, A., Tay, S. S., Tan, P. S., Bowen, D. G., Koch-Nolte, F., Rissiek, B., Carbone, F. R., Crabb, B. S., Lahoud, M., Cockburn, I. A., Mueller, S. N., Bertolino, P., McFadden, G. I., Caminschi, I., & Heath, W. R.
Affiliations
  • Burnet Institute (AU)
  • The University of Melbourne (AU)
  • The University of Sydney (AU)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Australian National University (AU)
Corresponding author
  • Caminschi, Irina
  • Heath, William R.
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2016-10
Volume
45
Issue
4
Pages
889-902
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2016.08.011
OpenAlex
W2525642000
Cited by
438
References
0
Citations by year
2026: 30 · 2025: 42 · 2024: 38 · 2023: 41 · 2022: 42 · 2021: 70 · 2020: 59 · 2019: 47 · 2018: 47 · 2017: 18 · 2016: 3
FWCI
38.01
Type
journal article
Language
en
Update notices
erratum (2019-10-15)
Open access
Licence
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion)
Funders
  • National Health and Medical Research Council of Australia
  • Australian Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
malaria, liver-stage immunity, tissue-resident memory T cells, CD8+ T cells, Plasmodium, dendritic cell priming, liver inflammation, malaria vaccine
MeSH terms
Animals, Dendritic Cells, Immunologic Memory, Liver, Liver Diseases, Malaria, Culicidae, Plasmodium berghei, Vaccination, Malaria Vaccines, CD8-Positive T-Lymphocytes, Hepatocytes, Sporozoites, Mice

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