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Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Open accessAbstract
In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably depend upon development of a broadly protective vaccine. To better understand immune requirement for protection, we examined liver-stage immunity after vaccination with irradiated sporozoites, an effective though logistically difficult vaccine. We identified a population of memory CD8+ T cells that expressed the gene signature of tissue-resident memory T (Trm) cells and remained permanently within the liver, where they patrolled the sinusoids. Exploring the requirements for liver Trm cell induction, we showed that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge. Our study highlights the immune potential of liver Trm cells and provides approaches for their selective transfer, expansion, or depletion, which may be harnessed to control liver infections or autoimmunity.
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“In contrast to circulating memory CD8 T cells, CD8 TRM cells in many tissues maintain high levels of the cytotoxic mediator granzyme B (8, 26, 45).”
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“Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection.”
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“Similar to their positioning at epithelial surfaces in barrier tissues, TRM in the brain and liver are also preferentially located at potential pathogen entry sites, be it in meninges and close to brain blood vessels (32) or liver sinusoids (25).”
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Self-citationThe Clinical Significance of Hepatic CD69+CD103+CD8+ Resident‐Memory T Cells in Autoimmune Hepatitis
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“The majority of hepatic CD8 TRM cells express CD69; however, some of them lack expression of CD103 (35, 49, 52).”
BackgroundInfluentialHuman Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence
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BackgroundImmune surveillance of the liver by T cells
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Prime and target immunization protects against liver-stage malaria in mice
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“Although saturation in TRM formation must be carefully distinguished from saturation of other upstream immune responses (78), identifying potential carrying capacities is important as the density of Ag-specific TRM within a tissue can influence the efficacy of protection (11, 58).”
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Self-citationThe liver as a central "hub" of the immune system: pathophysiological implications
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Metadata
- Authors
- Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., Li, J., Davey, G. M., Kato, Y., Devi, S., Skandari, R., Pauley, M., Manton, J. H., Godfrey, D. I., Braun, A., Tay, S. S., Tan, P. S., Bowen, D. G., Koch-Nolte, F., Rissiek, B., Carbone, F. R., Crabb, B. S., Lahoud, M., Cockburn, I. A., Mueller, S. N., Bertolino, P., McFadden, G. I., Caminschi, I., & Heath, W. R.
- Affiliations
- Burnet Institute (AU)
- The University of Melbourne (AU)
- The University of Sydney (AU)
- University Medical Center Hamburg-Eppendorf (DE)
- Australian National University (AU)
- Corresponding author
- Caminschi, Irina
- Heath, William R.
- ORCID
- Ng, Wei Yi
- Holz, Lauren E.
- Ma, Joel Z.
- Zaid, Ali
- Mollard, Vanessa
- Cozijnsen, Anton
- Li, Jessica
- Davey, Gayle M.
- Kato, Yu
- Devi, Sapna
- Pauley, Michael
- Manton, Jonathan H.
- Godfrey, Dale I.
- Braun, Asolina
- Tay, Szun Szun
- Tan, Peck Szee
- Bowen, David G.
- Rissiek, Björn
- Crabb, Brendan S.
- Lahoud, Mireille
- Cockburn, Ian A.
- Mueller, Scott N.
- Bertolino, Patrick
- McFadden, Geoffrey I.
- Caminschi, Irina
- Heath, William R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 45
- Issue
- 4
- Pages
- 889-902
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2525642000
- Cited by
- 438
- References
- 0
- Citations by year
- 2026: 30 · 2025: 42 · 2024: 38 · 2023: 41 · 2022: 42 · 2021: 70 · 2020: 59 · 2019: 47 · 2018: 47 · 2017: 18 · 2016: 3
- FWCI
- 38.01
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-10-15)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- National Health and Medical Research Council of Australia
- Australian Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- malaria, liver-stage immunity, tissue-resident memory T cells, CD8+ T cells, Plasmodium, dendritic cell priming, liver inflammation, malaria vaccine
- MeSH terms
- Animals, Dendritic Cells, Immunologic Memory, Liver, Liver Diseases, Malaria, Culicidae, Plasmodium berghei, Vaccination, Malaria Vaccines, CD8-Positive T-Lymphocytes, Hepatocytes, Sporozoites, Mice
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