The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
Open accessAbstract
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making them promising leads for vaccine design. Wild-type Env glycoproteins lack detectable affinity for supersite-bnAb germline precursors and are therefore unsuitable immunogens to prime supersite-bnAb responses. We employed mammalian cell surface display to design stabilized Env trimers with affinity for germline-reverted precursors of PGT121-class supersite bnAbs. The trimers maintained native-like antigenicity and structure, activated PGT121 inferred-germline B cells ex vivo when multimerized on liposomes, and primed PGT121-like responses in PGT121 inferred-germline knockin mice. Design intermediates have levels of epitope modification between wild-type and germline-targeting trimers; their mutation gradient suggests sequential immunization to induce bnAbs, in which the germline-targeting prime is followed by progressively less-mutated design intermediates and, lastly, with native trimers. The vaccine design strategies described could be utilized to target other epitopes on HIV or other pathogens.
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Cites
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Walker, L. M., Phogat, S. K., Chan-Hui, P.-Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., et al. (2009) · Science · doi:10.1126/science.1178746 · Cited by 1,723
Self-citationBroad neutralization coverage of HIV by multiple highly potent antibodies
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Self-citationSequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
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Self-citationStructural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
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Self-citationCo-evolution of a broadly neutralizing HIV-1 antibody and founder virus
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Self-citationBroad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
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Self-citationCrystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
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Self-citationRational HIV Immunogen Design to Target Specific Germline B Cell Receptors
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Self-citationSequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice
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Metadata
- Authors
- Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., Garces, F., Freund, N. T., Gitlin, A. D., Menis, S., Georgeson, E., Kubitz, M., Adachi, Y., Jones, M., Mutafyan, A. A., Yun, D. S., Mayer, C. T., Ward, A. B., Burton, D. R., Wilson, I. A., Irvine, D. J., Nussenzweig, M. C., & Schief, W. R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 45
- Issue
- 3
- Pages
- 483-496
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2520562417
- Cited by
- 401
- References
- 60
- FWCI
- 29.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., Garces, F., Freund, N. T., Gitlin, A. D., Menis, S., Georgeson, E., Kubitz, M., Adachi, Y., . . . Schief, W. R. (2016). HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. https://doi.org/10.1016/j.immuni.2016.08.016
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