The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function
Open accessAbstract
Summary Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-κB. In Tconv cells, NF-κB regulates expression of genes essential for T cell activation, proliferation and function. However the role of NF-κB in Treg function remains unclear. We conditionally deleted canonical NF-κB members p65 and c-Rel in developing and mature Treg cells and found they have unique but partially redundant roles. c-Rel was critical for thymic Treg development while p65 was essential for mature Treg identity and maintenance of immune tolerance. Transcriptome and NF-κB p65 binding analyses demonstrated a lineage specific, NF-κB-dependent transcriptional program, enabled by enhanced chromatin accessibility. These dual roles of canonical NF-κB in Tconv and Treg cells highlight the functional plasticity of the NF-κB signaling pathway and underscores the need for more selective strategies to therapeutically target NF-κB.
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Metadata
- Authors
- Oh, H., Grinberg-Bleyer, Y., Liao, W., Maloney, D., Wang, P., Wu, Z., Wang, J., Bhatt, D. M., Heise, N., Schmid, R. M., Hayden, M. S., Klein, U., Rabadan, R., & Ghosh, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 47
- Issue
- 3
- Pages
- 450-465.e5
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2752933178
- Cited by
- 226
- References
- 7
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Oh, H., Grinberg-Bleyer, Y., Liao, W., Maloney, D., Wang, P., Wu, Z., Wang, J., Bhatt, D. M., Heise, N., Schmid, R. M., Hayden, M. S., Klein, U., Rabadan, R., & Ghosh, S. (2017). An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. https://doi.org/10.1016/j.immuni.2017.08.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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