Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression
Zhu, Yu, Herndon, John M., Sojka, Dorothy K., Kim, Ki-Wook, Knolhoff, Brett L., Zuo, Chong, Cullinan, Darren R., Luo, Jingqin +7 more·2017·Immunity
Cited by (180)
Items 101–180 of 180
- The Impact of the Cancer Microenvironment on Macrophage PhenotypesSunyoung Ham, Luize Goncalves Lima, Erica S. H. Lek, Andreas Möller · 2020 · Frontiers in Immunology
- Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to interventionHancheng Wu, Jing Li, Ruilin Yao, Jing Liu, Lili Su, Wenjie You · 2025 · Theranostics
- Brain metastasis models: What should we aim to achieve better treatments?Mariam Masmudi‐Martín, Lucía Zhu, Macarena Sánchez‐Navarro, Neibla Priego, María Casanova-Acebes, Victor Ruiz‐Rodado, Ernest Giralt, Manuel Valiente · 2020 · Advanced Drug Delivery Reviews
- Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases.Ziqi Yue, L. Nie, Peng Zhang, Qin Chen, Q. Lv, Qi Wang · 2020 · Cellular Immunology
- Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progressionViktoria Plackoska, Dania Shaban, Anastasia Nijnik · 2022 · Frontiers in Immunology
- Emerging macrophage-based therapies for cancer: a review of preclinical and clinical advancesJan Brancewicz, Paulina Kucharzewska · 2025 · Frontiers in Immunology
- Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic CancerWenting Du, Marina Pasca di Magliano, Yaqing Zhang · 2021 · Frontiers in Oncology
- TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and functionMuhammad Shamsul Alam, Matthias M. Gaida, Hagen Roland Witzel, Shizuka Otsuka, Aamna J. Abbasi, Theresa M. Guerin, Abdalla Amr Abdelmaksoud, Nathan W. Wong, Maggie Cam, Serguei Kozlov et al. · 2024 · Cell Reports Medicine
- Single-cell RNA sequencing to characterize the response of pancreatic cancer to anti-PD-1 immunotherapyJing Zhou, Yuexu Jiang, Yue Huang, Qiongling Wang, Jussuf T. Kaifi, Eric T. Kimchi, Chiswili Yves Chabu, Zhenguo Liu, Trupti Joshi, Guangfu Li · 2021 · Translational Oncology
- S100A11: A Potential Carcinogen and Prognostic Marker That Correlates with the Immunosuppressive Microenvironment in Pan-CancerXiaozhen Ji, Xin Yu Qin, Xiuming Huang, Wei Wang, Huiyan Li, Chuizhi Zheng, Yanjing Huang · 2023 · Journal of Cancer
- Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchymeVasiliki Koliaraki, Ana Raquel Henriques, Alejandro Prados, George A. Kollias · 2020 · The Journal of Experimental Medicine
- Cancer Immunotherapy: Targeting Tumor-Associated Macrophages by Gene SilencingKarin Zins, Dietmar Abraham · 2020 · Methods in molecular biology
- An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer TherapyYuta Izumi, Masashi Kanayama, Zhongchuzi Shen, Masayuki Kai, Shunsuke Kawamura, Megumi Akiyama, Masahide Yamamoto, Toshikage Nagao, Keigo Okada, Norihiko Kawamata et al. · 2021 · Frontiers in Immunology
- The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targetsHirotake Tsukamoto, Yoshihiro Komohara, Hiroyuki Oshiumi · 2021 · Human Cell
- Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signalingKristina Marinak Whately, Nisitha Sengottuvel, Lincy Edatt, Sonal Srivastava, Allison T Woods, Yi‐Hsuan Tsai, Alessandro Porrello, Matthew P. Zimmerman, Aaron C Chack, Stuart R. Jefferys et al. · 2024 · JCI Insight
- BTLA+CD200+ B cells dictate the divergent immune landscape and immunotherapeutic resistance in metastatic vs. primary pancreatic cancerBrian E. Diskin, Salma Adam, Gustavo Sanchez Soto, Miguel Liria, Berk Aykut, Belen Sundberg, Eric H. Li, Joshua Leinwand, Ruonan Chen, Mirhee Kim et al. · 2022 · Oncogene
- Pushing Past the Blockade: Advancements in T Cell-Based Cancer ImmunotherapiesJessica Waibl Polania, Emily Lerner, Daniel S. Wilkinson, Alexandra M. Hoyt-Miggelbrink, Peter Edward Fecci · 2021 · Frontiers in Immunology
- Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical SetbacksKelvin K. Tsai, Tze‐Sian Chan, Yuval Shaked · 2019 · Journal of Clinical Medicine
- Emerging therapeutics targeting tumor-associated macrophages for the treatment of solid organ cancersDandan Li, Udo Rudloff · 2025 · Expert Opinion on Emerging Drugs
- Stromal regulation of tumor-associated lymphaticsHafsa Munir, Corrado Mazzaglia, Jacqueline D. Shields · 2020 · Advanced Drug Delivery Reviews
- Autofluorescence identifies highly phagocytic tissue-resident macrophages in mouse and human skin and cutaneous squamous cell carcinomaPierre Bourdely, Luciana Petti, Sokchea Khou, Aïda Meghraoui, Roxane Elaldi, Julie Cazareth, Noushin Mossadegh‐Keller, Julien Boyer, Michael H. Sieweke, Gilles Poissonnet et al. · 2022 · Frontiers in Immunology
- Pirfenidone alleviates fibrosis by acting on tumour–stroma interplay in pancreatic cancerYalan Lei, Jin Xu, Mingming Xiao, Di Wu, He Xu, Jing Yang, Xiaoqi Mao, Haoqi Pan, Xianjun Yu, Si Shi · 2024 · British Journal of Cancer
- Unveiling the immunosuppressive landscape of pancreatic ductal adenocarcinoma: implications for innovative immunotherapy strategiesSongyu Guo, Zhenxia Wang · 2024 · Frontiers in Oncology
- Tumor-associated macrophages in canine visceral hemangiosarcomaMikael Kerboeuf, Didrik Andreas Haugeberg, Tobias Olsen, Linn Kaia Sørling, Erling Olaf Koppang, Lars Moe, Anita Haug Haaland · 2023 · Veterinary Pathology
- Reciprocal Modulation of Tumour and Immune Cell Motility: Uncovering Dynamic Interplays and Therapeutic ApproachesAngelo Aquino, Ornella Franzese · 2025 · Cancers
- Early Life Inflammation and the Developing Hematopoietic and Immune Systems: The Cochlea as a Sensitive Indicator of DisruptionKelly Otsuka, Christopher Nielson, Matthew A. Firpo, Albert H. Park, Anna E. Beaudin · 2021 · Cells
- Therapeutic targeting of FOSL1 and RELA-dependent transcriptional mechanisms to suppress pancreatic cancer metastasisJoana E. Aggrey-Fynn, Meghana Manjunath, Ashish Rajput, Amro M. Abdelrahman, Julia Thiel, Mark Joseph Truty, Andrew G. Clark, Meng Dong, Steven A. Johnsen · 2025 · Cell Death and Disease
- Nano-delivery of Gemcitabine Derivative as a Therapeutic Strategy in a Desmoplastic KRAS Mutant Pancreatic CancerManisit Das, Jun Li, Michelle Bao, Leaf Huang · 2020 · The AAPS Journal
- Targeting tumor-associated CCR2 + macrophages to inhibit pancreatic cancer recurrence following irreversible electroporationWeichen Xu, Shaoyue Li, Xuexia Shan, Qiao Wang, Xinhua Chen, Shengbo Wu, Yincheng Gao, Dan-Dan Shan, Shi-Si Ding, Weiwei Ren et al. · 2025 · Science Advances
- Therapeutic targeting of tumour-associated macrophage receptorsRosa Gomes Alves Martins, Mehmet M Tekin, Mark Steven Cragg, Ali Roghanian · 2024 · Immunotherapy Advances
- Modulation of infiltrating CD206 + macrophages restricts progression of pulmonary lymphangioleiomyomatosisHeng-Jia Liu, Rémi Diesler, Joelle Chami, Boxiang Wu, Heng Du, Yue Jin, Melissa Daou, Nicola Alesi, Damir Khabibullin, Caroline Leroux et al. · 2025 · European Respiratory Journal
- Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpointsBeibei Ran, Lingjun Xiao, Yan Liu, Chenglin Zhang, Lingkai Kong, Yuxin Zhang, Xiaosong Gu, Chunping Jiang, Junhua Wu · 2025 · Journal of Advanced Research
- IRF8 Governs Tumor-Associated Macrophage Control of T Cell ExhaustionBriana G. Nixon, Fengshen Kuo, Ming Liu, Kristelle J. Capistrano, Mytrang Do, Ruth A. Franklin, Xiaodi Wu, Emily R. Kansler, Raghvendra Mohan Srivastava, Tanaya A. Purohit et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐ReviewAnghesom Ghebremedhin, Judith A. Varner · 2025 · Immunology
- Targeting the Tumor Immune Microenvironment in Triple-Negative Breast Cancer: The Promise of PolyphenolsAaron L. Hilliard, Tanya D. Russell, Patricia Mendonca, Karam F. A. Soliman · 2025 · Cancers
- Pan-Cancer Single-Cell RNA Sequencing Analysis Refines Multi-Origin Monocyte and Macrophage LineagesTruc Do Thanh. Nguyen, Andrew Lee, Hyun Jung Park, Nameeta Shah, Bayrta Mandzhieva, Dong‐Sup Lee, Inkyung Jung, Woong‐Yang Park · 2025 · Cancer Immunology Research
- Mechano-regulation of cancer cell memory in tumor progression and therapyYunjia Qu, Jiaxin Cui, Zhiang Wu, Peixiang He, Fan Wei, Tianze Guo, Yixuan Huang, Xi Yu, Mishel Tsoy, Kunshu Liu et al. · 2025 · Mechanobiology in Medicine
- Inflammation drives age-induced loss of tissue resident macrophagesKémy Adé, Javier Saenz Coronilla, Dorian Obino, Tobias Weinberger, Caroline Kaiser, Sébastien Mella, Cheng Chen, Lida Katsimpardi, Catherine Werts, Han Li et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancerCaronni, Nicoletta, Montaldo, Elisa, Mezzanzanica, Luca, Cilenti, Francesco, Genua, Marco, Ostuni, Renato · 2021 · Immunological Reviews
- Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancerRenzo Emanuel Vera, María Julia Lamberti, Alina L. González, Martín E. Fernández-Zapico · 2024 · Pancreatology
- The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of MiceAna S. Leal, Karen T. Liby · 2024 · International Journal of Molecular Sciences
- Macrophages inhibit and enhance endometriosis depending on their originChloe Hogg, Panir, Kavita, Priya Dhami, Matthew Rosser, Matthias Mack, Daniel Y. H. Soong, Jeffrey W. Pollard, S. Jenkins, Andrew W. Horne, Erin Greaves · 2021 · University of Regensburg Publication Server (University of Regensburg)
- The origin and polarization of Macrophages and their role in the formation of the Pre-Metastatic niche in osteosarcomaGuisen Lai, Xinyi Zhao, Yuanquan Chen, Tianwei Xie, Zepeng Su, Jiajie Lin, Keng Chen, Keng Chen · 2025 · International Immunopharmacology
- Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programmingPeter L Wang, Aldrin Kay‐Yuen Yim, Ki-Wook Kim, Denis R. Avey, Rafael Sanguinetti Czepielewski, Marco Colonna, Jeffrey Milbrandt, Gwendalyn J. Randolph, The Immunological Genome Project · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- An Overview of Advances in Cell-Based Cancer Immunotherapies Based on the Multiple Immune-Cancer Cell InteractionsJialing Zhang, Stephan Stanislaw Späth, Sherman M. Weissman, Samuel G. Katz · 2019 · Methods in molecular biology
- Advances in Antitumor Strategies Targeting Tumor-Associated Macrophages枫 杨 · 2022 · World Journal of Cancer Research
- Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traitsChiara Vitale, Andrea Petretto, Katia Cortese, Sonia Carta, Alessandra Dondero, Chiara Lavarello, Davide Cangelosi, Martina Morini, Francesca Bellora, Pietro Arnaldi et al. · 2025 · OncoImmunology
- Role of innate immunity in the development of cancer immunotherapy immune-mediated adverse eventsÁlvaro Sierra-Salazar, Yatzil Reyna-Juárez, Beatriz Alcalá‐Carmona, Rodrigo Quintana-Tenorio, Jennifer Tiaré Balderas-Miranda, Johan Camacho-Pérez, Jiram José Torres-Ruiz · 2026 · Frontiers in Immunology
- Disarming the “Neural Hijack”: Repurposing neuroactive drugs for cancer therapyMing-Zhu Jin, Hao-Ran Dang, Wei-Lin Jin · 2026 · Pharmacology & Therapeutics
- LOXL2 in pancreatic tumourigenesis: the complexity of tumour–stromal crosstalk exemplifiedSeth B. Coffelt, Jennifer P. Morton · 2022 · Gut
- Establishment of a prognostic prediction system based on tumor microenvironment of pancreatic cancerYan Feng, Pengcheng Li, Fang Yang, Ke Xu · 2022 · Medicine
- A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicityEban A. Hanna, Ashleigh J. Crawford, Wenxuan Du, Adrian C. Johnston, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim et al. · 2026 · Cell Reports Methods
- YBX1 takes actions on triggering M2-like polarization of macrophages and stabilizing CXCL8 mRNA to exhibit its metastatic potential in bladder cancerHuihui Yang, Chuanchi Zhou, Zheng Zhou, Fan Zhang, Liang Tong · 2026 · International Immunopharmacology
- Sex differences in innate immune cell responses: Impact on cancer immunity and response to therapySina Ramin, Terry R. Medler · 2026 · Frontiers in Immunology
- Tumor Microenvironment Complexity: A Pathological Milieu that Innately Modulates Cancer ProgressionLiliana-Roxana Balahura, Andreea Daniela Lazăr, Sorina Dinescu, Marieta Costache · 2022 · Springer eBooks
- Tumor-Associated Myeloid Cells in Cancer ProgressionTamara Gulić, Rita Silva-Gomes, Sadaf Davoudian, Marina Sironi, Paola Allavena, Alberto Mantovani, Barbara Bottazzi · 2020 · Springer eBooks
- Macrophages can either inhibit or enhance endometriosis depending on their originChloe Hogg, Priya Dhami, M. Rosser, M. Mack, D. Soong, J. Pollard, S. Jenkins, A. Horne, E. Greaves · 2020 · bioRxiv
- Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal AdenocarcinomaPritha Adhikary, Jayati L. Chakrabarti, Saptarshi Mallick, Xi Sun, Ugonna Ezuma-Igwe, Abigail G. Branch, Jiang Wang, Nicolas Braissand, Megan P. Corbett, Sangmin Kim et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Obstruction of Capillaries by circulating large Monocytes causes Multi Organ Dysfunction Syndrome (MODS) in Acute PancreatitisAnika Wilden, Juliane Glaubitz, Oliver Otto, Doreen Biedenweg, Matthias A. Nauck, Matthias Mack, Silvia Ribback, Barbara M. Bröker, Sabrina Freiin von Rheinbaben, Markus M. Lerch et al. · 2021 · Research Square
- Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control.Anne E. Geller · 2021
- Macrophages and their antitumor activityZhixia Zhou · 2022 · Elsevier eBooks
- The role of breast cancer derived-exosomes in the tumour micro-environmentSunyoung Ham · 2021 · Queensland University of Technology
- Phenotypic and functional diversity of tumor-associated macrophagesDiletta Di Mitri, Alberto Mantovani, Federica Marchesi · 2024 · Elsevier eBooks
- Intraductal Papillary Mucinous Neoplasm Cellular Plasticity is Linked with Repeat Element DysregulationAmaya Pankaj, Michael J. Raabe, M. Lisa Zhang, Yuhui Song, Bidish K. Patel, Katherine Xu, Joshua R. Kocher, Evan Lang, Peter Richieri, Nicholas J. Caldwell et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Tumor Microenvironment Complexity: A Pathological Milieu That Innately Modulates Cancer ProgressionLiliana-Roxana Balahura, Andreea Daniela Lazăr, Sorina Dinescu, Marieta Costache · 2025 · Springer eBooks
- TAMs-derived IL-1β inducing DDX21 enhances CRC proliferation and metastasis via JAK2/STAT3 pathwayYu Wang, Tiantian Zhen, Shujin He, Yuting Wang, Lin Chen, Yongyu Chen, Huijuan Shi, Anjia Han · 2025 · Cancer Treatment and Research Communications
- ADAM17-dependent Autocrine and Paracrine Signaling Promotes Pancreatic Premalignant ProgressionHui-Ju Wen, Erick T. Davis, Jacee S. Moore, Sydney M. Brender, Simone Benitz, Allison M. Wombwell, Ian M. Loveless, Daniel W. Long, Daniel James Salas-Escabillas, Justin Lee et al. · 2025 · Cellular and Molecular Gastroenterology and Hepatology
- A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancerNa Hyun Kim, Young Min Song, San Sung Kwon, Sang Hyub Lee, Eun Na Kim, Jung Joo Hong, Seung Hyeok Seok, Yi Rang Na · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Absence of Interstitial Cells of Cajal in Human Colonic Muscularis Mucosae: Implications for Mucosal Motility Control.M. Rusu, D. Pirici, Ivan Varga, M. Nicolescu · 2026 · Annals of Anatomy
- Interleukin-1 receptor type 1 in pancreatic cancer progression and metastasis: a reviewKenta Saito, Yoichi Matsuo, Yuki Denda, Keisuke Nonoyama, Hiromichi Murase, Tomokatsu Kato, Yushi Yamakawa, Takafumi Sato, Hiroyuki Sagawa, Ryo Ogawa et al. · 2026 · International Journal of Clinical Oncology
- Targeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunityPanzhu Bai, Chengmin Liu, Changying Fu, Renwei Cai, Yanyan Ding, Meiling Quan, Yuhao Ye, Zimo Zhang, Yuan Li, Yanfen Xu et al. · 2026 · Nature Communications
- Caractérisation ontogénique, phénotypique et fonctionnelle des cellules dendritiques et des macrophages dans les carcinomes épidermoïdes cutanésPierre Bourdely · 2017 · theses.fr (ABES)
- L'activité kinase de FAK dans les fibroblastes associés au cancer : régulateur clé de la progression de l'adénocarcinome pancréatique canalaireSonia Zaghdoudi · 2019 · theses.fr (ABES)
- Activation des lymphocytes T gamma delta dans les cancersChloé Laplagne · 2020 · theses.fr (ABES)
- Characterization of tumor-infiltrating myeloid cells in a mouse model of melanoma : roles of IL-4Rα signaling and tumor cell immunogenicityElodie Baudoin · 2021 · theses.fr (ABES)
- Kupffer Cell Maintenance in Tissue Repair and AgeingKémy Adé · 2021 · theses.fr (ABES)
- Role of the early stage stroma-immune interactions in the tumor microenvironment of pancreatic adenocarcinomaZhichong Wu · 2021
- An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progressionJaroslav Žák, Hui Chen, Erpei Wang, Patrick Ozark, Giuliana P. Mognol, MATTHEW Dae-Young PARK, Nadine Fournier, Priyanka Chaudary, Jingjing Hu, Ryan M. Shepard et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Mitochondrial regulation of tumor-associated macrophage functionJiabao Xu, Yangtao Liu, Hongjie Zhang, Zhao Yuan, Yu Sheng, Xiaodong Wang, Hanbin Liu, Fei Zhong, Hui Zhang, Han Xiong et al. · 2026 · Frontiers in Immunology
- Integrated single-cell and proteomic profiling of pancreatic neoplasia identifies tissue markers that outperform established diagnostic markers in distinguishing cancer from precursor lesionsThoa T Tran, Hoang Phuong Uyen Nguyen, Johannes F. Fahrmann, Duy Truong Pham, Loan Bui, Nhat Huy Bui, Christian Max Schmidt · 2026 · medRxiv