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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
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“In addition, microglial functions vary across different ages, disease pathologies, and between sexes10–16.”
From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [12]
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“CD38 expression was associated with neuroinflammation with greater amounts of proinflammatory macrophages/microglia in mouse brains160,165.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [160]
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“CD38 expression increases in the course of Alzheimer disease progression159–161”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [160]
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“On the basis of high-parameter mass cytometry and single-cell RNA-sequencing studies, the dural macrophages appear to be distinct from those residing in the pia and underlying parenchyma (73, 94).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [94]
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Research works printed but not linked: 3
- Baruch, K., Ron-Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013). CNS- specific immunity at the choroid plexus shifts toward destructive Th2 inflam- mation in brain aging. Proc. Natl. Acad. Sci. USA 110, 2264-2269.
- Kotecha, N., Krutzik, P.O., and Irish, J.M. (2010). Web-based analysis and publication of flow cytometry experiments. In Current Protocols in Cytometry (Hoboken, NJ, USA: John Wiley & Sons, Inc.).
- Mrdjen, D., Hartmann, F.J., and Becher, B. (2017). High dimensional cytometry of central nervous system leukocytes during neuroinflammation. In Inflammation: Methods and Protocols, B.E. Clausen and J.D. Laman, eds. (New York, NY: Springer New York), pp. 321-332.
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Additional file 3 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.26709308
Wang, A. Z., Bowman-Kirigin, J. A., Desai, R., Kang, L.-I., Patel, P. R., Patel, B., Khan, S. M., Bender, D. E., Marlin, M. C., Liu, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19736402
Additional file 7 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.26709320
Hawes, C. E., Elizaldi, S. R., Beckman, D., Diniz, G. B., Shaan Lakshmanappa, Y., Ott, S. P., Durbin-Johnson, B. P., Dinasarapu, A. R., Gompers, A., Morrison, J. H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21293526
Additional file 8 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.26709323
Additional file 1 of Impact of aging on meningeal gene expression
Neutzner, M., Kohler, C., Frank, S., Killer, H. E., & Neutzner, A. (2024) · Figshare · doi:10.6084/m9.figshare.26566754
Toutonji, A., Krieg, C., Borucki, D. M., Mandava, M., Guglietta, S., & Tomlinson, S. (2023) · Figshare · doi:10.6084/m9.figshare.23505337
Additional file 4 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.26709311
Additional file 2 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.25658669
Additional file 6 of CSF1R antagonism results in increased supraspinal infiltration in EAE
Wang, M., Caryotakis, S. E., Smith, G., Nguyen, A. V., Pleasure, D., & Soulika, A. M. (2024) · Figshare · doi:10.6084/m9.figshare.26709317
de Miranda, A. S., Vieira, É. L. M., Teixeira, A. L., & Bauer, M. E. (2026) · NeuroImmunoModulation · doi:10.1159/000550781 · Cited by 1
Kaplanis, S. I., Spyridakos, D., Zyganitidis, I., Lygeraki, A., Kaffe, D., Georgilis, A., Ieremiadis, V., Petsangouraki, S., Theodorakis, Κ., Savvaki, M., et al. (2026) · Glial health research. · doi:10.1016/j.ghres.2026.100016
Brain-Resident CD8 + T Cells Regulate Neuronal Activity and Behavior via Interferon-GammaPreprint
Park, K., Jang, J., Jeon, S., Hwang, S., Choi, K., cox, T., Ngiow, S. F., flores, J., Harrison, C. F., Liu, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.24.746768 · Cited by 1
Mendes, N. F. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10081-2
Harris, A. S., Rouse, J. A., 郭广冉, Fernández-Maestre, I., Pal, S., Oh, B., Li, S., See, W. Y., Anderson, A., Gewolb, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.27.754777
Cai, D., Ke, X., Luo, F., Li, Y., Cai, H., 祝继洪, Chen, Y., & Chen, G. (2026) · Reviews in the Neurosciences · doi:10.1515/revneuro-2026-0136
“…operational de fi nition leads to the next section, which examines the speci fi c lipid-handling pathways that may become limiting after perioperative stress (Galatro et al. 2017; Grabert et al. 2016; Jordão et al. 2019; Masuda et al. 2019; Mrdjen et al. 2018; Rachmian et al. 2024; Zhou et al. 2020).”
Metadata
- Authors
- Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., Greter, M., & Becher, B.
- Affiliations
- University of Zurich (CH)
- Charité – Universitätsmedizin Berlin (DE)
- University of Virginia (US)
- University of Geneva (CH)
- Corresponding author
- Becher, Burkhard
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 48
- Issue
- 3
- Pages
- 599
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3091919022
- Cited by
- 220
- References
- 0
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 32 · 2023: 23 · 2022: 31 · 2021: 34 · 2020: 28 · 2019: 19 · 2018: 21
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- myeloid cell subsets, aging, Alzheimer's disease, multiple sclerosis, experimental autoimmune encephalitis, APP/PS1 mice, fate mapping, single-cell cytometry, mass cytometry
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