Merkler, Doron

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,089

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 1,010

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

Nikić, I., Merkler, D., Sorbara, C., Brinkoetter, M., Kreutzfeldt, M., Bareyre, F. M., Brück, W., Bishop, D., Misgeld, T., & Kerschensteiner, M. (2011) · Nature Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 713

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Goldmann, T., Zeller, N., Raasch, J., Kierdorf, K., Frenzel, K., Ketscher, L., Basters, A., Staszewski, O., Brendecke, S. M., Spiess, A., et al. (2015) · The EMBO Journal

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 223

A new focal EAE model of cortical demyelination: Multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination

Merkler, D. (2006) · Brain

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 222

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 220

The immune system bridges the gut microbiota with systemic energy homeostasis: focus on TLRs, mucosal barrier, and SCFAs

Spiljar, M., Merkler, D., & Trajkovski, M. (2017) · Frontiers in Immunology

Gut microbiota and healthImmune Response and Inflammation

Cited by 219

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

Datta, M., Staszewski, O., Raschi, E., Frosch, M., Hagemeyer, N., Tay, T. L., Blank, T., Kreutzfeldt, M., Merkler, D., Ziegler-Waldkirch, S., et al. (2018) · Immunity

Neuroinflammation and Neurodegeneration MechanismsHistone Deacetylase Inhibitors Research

Cited by 206

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

Di Liberto, G., Pantelyushin, S., Kreutzfeldt, M., Page, N., Musardo, S., Coras, R., Steinbach, K., Vincenti, I., Klimek, B., Lingner, T., et al. (2018) · Cell

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 195

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

Jürgens, T., Jafari, M., Kreutzfeldt, M., Bahn, E., Brück, W., Kerschensteiner, M., & Merkler, D. (2016) · Brain

Multiple Sclerosis Research StudiesNeuroscience and Neuropharmacology Research

Cited by 175

Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis

LIEBETANZ, D., & MERKLER, D. (2006) · Experimental Neurology

Multiple Sclerosis Research StudiesMotor Control and Adaptation

Cited by 166

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients

Migliorini, D., Dutoit, V., Allard, M., Grandjean Hallez, N., Marinari, E., Widmer, V., Philippin, G., Corlazzoli, F., Gustave, R., Kreutzfeldt, M., et al. (2019) · Neuro-Oncology

Glioma Diagnosis and TreatmentImmunotherapy and Immune Responses

Cited by 147

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

Manrique‐Hoyos, N., Jürgens, T., Grønborg, M., Kreutzfeldt, M., Schedensack, M., Kuhlmann, T., Schrick, C., Brück, W., Urlaub, H., Simons, M., et al. (2012) · Annals of Neurology

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 107

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

Raasch, J., Zeller, N., van Loo, G., Merkler, D., Mildner, A., Erny, D., Knobeloch, K.-P., Bethea, J. R., Waisman, A., Knust, M., et al. (2011) · Brain

Multiple Sclerosis Research StudiesNF-κB Signaling Pathways

Cited by 106

Tissue-resident CD8 + T cells drive compartmentalized and chronic autoimmune damage against CNS neurons

Frieser, D., Pignata, A., Khajavi, L., Shlesinger, D., Gonzalez-Fierro, C., Nguyen, X.-H., Yermanos, A., Merkler, D., Höftberger, R., Desestret, V., et al. (2022) · Science Translational Medicine

T-cell and B-cell ImmunologyMultiple Sclerosis Research Studies

Cited by 102

Negative Impact of Statins on Oligodendrocytes and Myelin Formation In Vitro and In Vivo

Klopfleisch, S., Merkler, D., Schmitz, M., Klöppner, S., Schedensack, M., Jeserich, G., Althaus, H. H., & Brück, W. (2008) · The Journal of Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 97

Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS

Vincenti, I., Page, N., Steinbach, K., Yermanos, A., Lemeille, S., Nunez, N., Kreutzfeldt, M., Klimek, B., Di Liberto, G., Egervari, K., et al. (2022) · Science Translational Medicine

T-cell and B-cell ImmunologyMultiple Sclerosis Research Studies

Cited by 70

Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination

Rodriguez, E. G., Wegner, C., Kreutzfeldt, M., Neid, K., Thal, D. R., Jürgens, T., Brück, W., Stadelmann, C., & Merkler, D. (2014) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 44

Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant

Schmidt, H., Raasch, J., Merkler, D., Klinker, F., Krauss, S., Brück, W., & Prinz, M. (2009) · Experimental Neurology

Multiple Sclerosis Research Studiesinterferon and immune responses

Cited by 31

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty

Merkler, D., Vincenti, I., Masson, F., & Liblau, R. S. (2022) · Current Opinion in Immunology

T-cell and B-cell ImmunologyMultiple Sclerosis Research Studies

Cited by 30

MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration

Winkler, I., Engler, J. B., Vieira, V., Bauer, S., Liu, Y.-H., Di Liberto, G., Grochowska, K. M., Wagner, I., Bier, J., Bal, L. C., et al. (2023) · Science Advances

Multiple Sclerosis Research StudiesMicroRNA in disease regulation

Cited by 22

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 16