Innate Lymphoid Cell Development: A T Cell Perspective
Open accessAbstract
Innate lymphoid cells (ILCs) and natural killer (NK) cells have garnered considerable interest due to their unique functional properties in immune defense and tissue homeostasis. Our current understanding of how these cells develop has been greatly facilitated by knowledge of T cell biology. Models of T cell differentiation provided the basis for a conceptual classification of these innate effectors and inspired a scheme of their activation and regulation. In this review, we discuss NK cell and ILC development from a "T cell standpoint" in an attempt to extend the analogy between adaptive T cells and their innate ILC and NK cell counterparts.
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The innate lymphoid cell developmental program appears to resemble the intrathymic T-cell program in many respects.
“So far the innate lymphoid cell developmental program in particular appears to resemble the intrathymic T-cell program in many respects (154–157), enough to raise the question of what makes T-cell precursors wait to activate genes like Tcf7 and Gata3 until they reach the thymus.”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [156]
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Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
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- Authors
- Cherrier, D. E., Serafini, N., & Di Santo, J. P.
- Affiliations
- Inserm (FR)
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 48
- Issue
- 6
- Pages
- 1091-1103
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2809494687
- Cited by
- 181
- References
- 7
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 23 · 2023: 14 · 2022: 29 · 2021: 24 · 2020: 28 · 2019: 29 · 2018: 3
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- innate lymphoid cells, natural killer cells, ILC development, T cell differentiation, tissue homeostasis, innate immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Immunity, Innate, Killer Cells, Natural, Lymphocytes, T-Lymphocytes
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