The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch
Open accessAbstract
SUMMARY Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation and hista-mine release. Recently, members of the Mas-related G-protein-coupled receptor (Mrgpr) family have been identified as mast cell receptors, but their role in itch is unclear. Here, we report that mast cell activation via Mrgprb2 evoked non-histaminergic itch in mice independently of the IgE-Fc epsilon RI (FcεRI)-hista-mine axis. Compared with IgE-FcεRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Mrgprb2 deficiency decreased itch in multiple preclinical models of allergic contact dermatitis (ACD), a pruritic inflammatory skin disorder, and both mast cell number and PAMP1–20 concentrations (agonist of the human Mrgprb2 homolog, MRGPRX2) were increased in human ACD skin. These findings suggest that this pathway may represent a therapeutic target for treating ACD and mast-cell-associated itch disorders in which antihistamines are ineffective.
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
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Self-citationMast cell secretory granules: armed for battle
Wernersson, S., & Pejler, G. (2014) · Nature Reviews Immunology · doi:10.1038/nri3690 · Cited by 906
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Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
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A subpopulation of nociceptors specifically linked to itch
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Mast Cell Biology at Molecular Level: a Comprehensive Review
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Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns
Galli, S. J., Gaudenzio, N., & Tsai, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071719-094903 · Cited by 367
Bile acids and their receptors in metabolic disorders
Fiorucci, S., Distrutti, E., Carino, A., Zampella, A., & Biagioli, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101094 · Cited by 258
The ingenious mast cell: contemporary insights into mast cell behavior and function
Dahlin, J. S., Maurer, M., Metcalfe, D. D., Pejler, G., Sagi‐Eisenberg, R., & Nilsson, G. (2022) · Allergy · doi:10.1111/all.14881 · Cited by 147
Metadata
- Authors
- Meixiong, J., Anderson, M., Limjunyawong, N., Sabbagh, M. F., Hu, E., Mack, M. R., Oetjen, L. K., Wang, F., Kim, B. S., & Dong, X.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 50
- Issue
- 5
- Pages
- 1163-1171.e5
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2940793909
- Cited by
- 369
- References
- 53
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Meixiong, J., Anderson, M., Limjunyawong, N., Sabbagh, M. F., Hu, E., Mack, M. R., Oetjen, L. K., Wang, F., Kim, B. S., & Dong, X. (2019). Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity. https://doi.org/10.1016/j.immuni.2019.03.013
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