IgE and mast cells in allergic disease
Open accessAbstract
Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence now suggests that both IgE and mast cells are also key drivers of the long-term pathophysiological changes and tissue remodeling associated with chronic allergic inflammation in asthma and other settings. Such potential roles include IgE-dependent regulation of mast-cell functions, actions of IgE that are largely independent of mast cells and roles of mast cells that do not directly involve IgE. In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders.
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The severity of MCA correlates with the extent of mediator release from MC during an anaphylactic reaction.
“the severity of MCA correlates with the extent of mediator release from MC during an anaphylactic reaction.”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [5]
The section “IgE and mast cells mediate an immediate hypersensitivity response” (page unavailable) says that mast-cell mediators induce an immediate reaction that can become anaphylaxis when systemic. It does not say that the severity of mast-cell activation correlates with the extent of mediator release during an anaphylactic reaction. (LLM, conf=0.82)
Experimental — accuracy not yet measuredMCA symptoms are caused by vasoactive and pro-inflammatory mediators released from MC upon activation by allergen via IgER cross-linking or other mechanisms.
“MCA symptoms are caused by several different vasoactive and pro-inflammatory mediators released from MC when these cells are activated by an allergen via IgER cross-linking or other mechanisms (1-5,29-31).”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [5]
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- Authors
- Galli, S. J., & Tsai, M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Galli, Stephen J
- Venue
- Nature Medicine
- Published
- 2012-05
- Volume
- 18
- Issue
- 5
- Pages
- 693-704
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3597223
- OpenAlex
- W1982386486
- Cited by
- 1,799
- References
- 172
- Citations by year
- 2026: 91 · 2025: 132 · 2024: 125 · 2023: 138 · 2022: 153 · 2021: 204 · 2020: 184 · 2019: 152 · 2018: 132 · 2017: 116 · 2016: 98 · 2015: 96 · 2014: 93 · 2013: 67 · 2012: 14
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA072074, CA 72074)
- National Institute of Allergy and Infectious Diseases (AI-070813, R01AI023990, R01AI070813, R37AI023990, AI-23990)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- immunoglobulin E, mast cells, asthma, allergic diseases, chronic allergic inflammation, tissue remodeling, anaphylaxis, asthma pathophysiology, asthma treatment
- MeSH terms
- Allergens, Animals, Humans, Hypersensitivity, Immunoglobulin E, Mast Cells, Receptors, IgE
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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