Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Open accessAbstract
Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by the process of efferocytosis that is anti-inflammatory. However, a number of pathologies have recently been linked to defective clearance of apoptotic cells. Perturbed clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at different stages of efferocytosis, and responses of phagocytes during efferocytosis, all of which can alter the homeostatic tissue environment. This review covers linkages of molecules involved in the different phases of efferocytosis to disease pathologies that can arise due to their loss or altered function.
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Efferocytosis can reprogram macrophages toward a proresolving, disease-suppressing state.
“Efferocytosis can reprogram macrophages to a proresolving, disease-suppressing state (12, 39)”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [39]
Macrophages interact with surrounding cells to maintain order and quickly remove potentially hazardous debris.
“Macrophages interact with the cells around them to maintain order and rapidly remove potentially hazardous debris (39).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [39]
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References 161 · Cited by 391
- Authors
- Morioka, S., Maueröder, C., & Ravichandran, K. S.
- Affiliations
- University of Virginia (US)
- Ghent University (BE)
- Corresponding author
- Ravichandran, Kodi S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 50
- Issue
- 5
- Pages
- 1149-1162
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC6721617
- OpenAlex
- W2945926178
- Cited by
- 391
- References
- 161
- Citations by year
- 2026: 58 · 2025: 62 · 2024: 55 · 2023: 77 · 2022: 54 · 2021: 38 · 2020: 37 · 2019: 10
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL120840)
- Deutsche Forschungsgemeinschaft (MA 7770/1-1)
- Foundation for the National Institutes of Health (GM064709)
- California Department of Fish and Game
- Mishima Kaiun Memorial Foundation
- National Institutes of Health (GM064709)
- Kanae Foundation for the Promotion of Medical Science
- Fonds Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, phagocytes, tissue homeostasis, inflammation, disease pathology
- MeSH terms
- Erythrocytes, Homeostasis, Humans, Phagocytes, Phagocytosis, Apoptosis
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