The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity
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(Immunity 49, 353-362.e1–e5; August 21, 2018) In the originally published Figure 6, the legend describing panel B was incorrect. The error occurred because the text from the legend describing Figure 5B had accidentally been copied. The corrected legend now appears online and in print here. Figure 6. Dietary AHR Ligands Can Halt Progression of Tumorigenesis (A) Villin-creR26Cyp1a1 were injected with 10 mg/kg of AOM followed with one cycle of 1% DSS on standard chow diet. For the second cycle of DSS, mice were put either on a purified diet or I3C diet until the end of the experiment. (B) Number of colon tumors in Villin-creR26Cyp1a1 n = 10 mice, fed purified or I3C diet after AOM/DSS treatment. (C) Representative image of colon after AOM/DSS treatment. (D and E) Size (D) and score (E) of tumors in Villin-creR26Cyp1a1 mice fed purified or I3C diet. (F) Representative images of hematoxylin and eosin (H&E) colon tumors in VillinCreR26Cyp1a1 mice fed purified or I3C diet. Error bars, mean + SEM. ∗p < 0.05, ∗ ∗p < 0.01, ∗ ∗ ∗p < 0.001, as calculated by paired t test. Furthermore, we were made aware of an error in Figure 2A in which a partial overlap of the panel for Ahr−/− is repeated in the image for R26Cyp1a1. This mistake happened during selection of the example panels from a multitude of images. Although it has no bearing on the validity of the data in this figure because panel A was purely illustrative to show different growth characteristics in AHR mutant colon organoids, we have now replaced this panel with a new panel for R26Cyp1a1 in Figure 2A. The corrected figure now appears online and in print here. The authors sincerely apologize for any confusion that these errors might have made for the readers.Figure 2AHR Pathway Is Required for Epithelial Cell Differentiation from Crypt Stem Cells (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier IntegrityMetidji et al.ImmunityAugust 14, 2018In BriefMetidji et al. show that deletion of Ahr in intestinal epithelial cells results in a defective barrier and unrestricted proliferation of intestinal stem cells (ISCs), culminating in malignant transformation. Activation of AHR by dietary ligands guards the ISC niche and maintains intestinal barrier homeostasis. Full-Text PDF Open Access
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Supplementation of dietary AhR ligands (like I3C) guarded the intestinal stem cell niche and maintained intestinal barrier function and decreased tumor burden in the azoxymethane-DSS-induced colon tumorigenesis model.
“Supplementation of dietary AhR ligands (like I3C) guarded the intestinal stem cell niche and maintained intestinal barrier function and decreased tumor burden in the azoxymethane-DSS–induced colon tumorigenesis model.100”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [100]
Deletion of AhR in intestinal epithelial cells led to a defective barrier and uncontrolled proliferation of intestinal stem cells, leading to increased tumors in an azoxymethane-DSS-induced colon tumorigenesis model.
“It was demonstrated by the Stockinger group that deletion of AhR in IECs led to a defective barrier and uncontrolled proliferation of intestinal stem cells, leading to increased tumors in an azoxymethane-DSS–induced colon tumorigenesis model.100”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [100]
Low levels of naturally occurring AhR ligands were reported in IBD patients.
“In parallel to these observations in mice, low levels of naturally occurring AhR ligands were reported in IBD patients.100”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [100]
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- Authors
- Metidji, A., Omenetti, S., Crotta, S., Li, Y., Nye, E., Ross, E., Li, V., Maradana, M. R., Schiering, C., & Stockinger, B.
- Corresponding author
- Schiering, Chris
- Stockinger, Brigitta
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 50
- Issue
- 6
- Pages
- 1542
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4247609803
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Immunity (publishedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- aryl hydrocarbon receptor, AhR ligands, isothiocyanates, intestinal barrier integrity, intestinal inflammation, colitis-associated colorectal cancer, AOM/DSS colitis, tumor suppression, epithelial differentiation, crypt stem cells, colon organoids, CYP1A1
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