The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo
Open accessAbstract
How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly activated cognate B cells, with little affinity discrimination. This led to strong early induction of the transcription factors IRF4 (interferon regulatory factor 4) and Bcl6, driving both early extrafollicular plasma cell and germinal center responses, in a CD4+ T-cell-dependent manner, involving B cells with a broad range of affinities. Low-valency antigens induced smaller effector B cell responses, with preferential recruitment of high-affinity B cells. Thus, antigen valency has multifaceted effects on B cell responses and can dictate affinity thresholds and competitive landscapes for B cells in vivo, with implications for vaccine design.
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Cites
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Self-citationT follicular helper cell biology: a decade of discovery and diseases
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Cited by
Novel approaches for vaccine development
Gebre, M. S., Brito, L. A., Tostanoski, L. H., Edwards, D. K., Carfi, A., & Barouch, D. H. (2021) · Cell · doi:10.1016/j.cell.2021.02.030 · Cited by 347
Capella-Pujol, J., de Gast, M., Radić, L., Zon, I., Chumbe, A., Koekkoek, S., Olijhoek, W., Schinkel, J., van Gils, M. J., Sanders, R. W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39690-0 · Cited by 12
(2026) · doi:10.1073/pnas.2532810123 · Cited by 8
Metadata
- Authors
- Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R., & Crotty, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 53
- Issue
- 3
- Pages
- 548-563.e8
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3080829022
- Cited by
- 269
- References
- 69
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R., & Crotty, S. (2020). Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo. Immunity. https://doi.org/10.1016/j.immuni.2020.08.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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