The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
The Intersection of Epigenetics and Metabolism in Trained Immunity
Open accessAbstract
The last few years have witnessed an increasing body of evidence that challenges the traditional view that immunological memory is an exclusive trait of the adaptive immune system. Myeloid cells can show increased responsiveness upon subsequent stimulation with the same or a different stimulus, well after the initial challenge. This de facto innate immune memory has been termed "trained immunity" and is involved in infections, vaccination and inflammatory diseases. Trained immunity is based on two main pillars: the epigenetic and metabolic reprogramming of cells. In this review we discuss the latest insights into the epigenetic mechanisms behind the induction of trained immunity, as well as the role of different cellular metabolites and metabolic networks in the induction, regulation and maintenance of trained immunity.
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Cites
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Cited by
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities
Li, X., Wang, H., Yu, X., Saha, G., Kalafati, L., Ioannidis, C., Mitroulis, I., Netea, M. G., Chavakis, T., & Hajishengallis, G. (2022) · Cell · doi:10.1016/j.cell.2022.03.043 · Cited by 328
Self-citationLiang, J., Zhu, F., Cheng, K., Ma, N., Ma, X., Feng, Q., Xu, C., Gao, X., Wang, X., Shi, J., et al. (2023) · Advanced Materials · doi:10.1002/adma.202306158 · Cited by 84
Lunjani, N., Ambikan, A. T., Hlela, C., Levin, M., Mankahla, A., Heldstab‐Kast, J. I., Boonpiyathad, T., Tan, G., Altunbulakli, C., Gray, C., et al. (2024) · Allergy · doi:10.1111/all.15832 · Cited by 25
Trained Immunity Causes Myeloid Cell Hypercoagulability
Rehill, A. M., McCluskey, S., Ledwith, A. E., Ryan, T. A. J., Ünlü, B., Leon, G., Charles-Messance, H., Gilbert, E. H., Klavina, P., Day, E. A., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads0105 · Cited by 12
Metadata
- Authors
- Fanucchi, S., Domínguez-Andrés, J., Joosten, L. A. B., Netea, M. G., & Mhlanga, M. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 54
- Issue
- 1
- Pages
- 32-43
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3100724954
- Cited by
- 428
- References
- 78
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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